Results 111 to 120 of about 440 (147)
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Advances in the research and application of neurokinin-1 receptor antagonists
Journal of Zhejiang University-SCIENCE BRecently, the substance P (SP)/neurokinin-1 receptor (NK-1R) system has been found to be involved in various human pathophysiological disorders including the symptoms of coronavirus disease 2019 (COVID-19). Besides, studies in the oncological field have demonstrated an intricate correlation between the upregulation of NK-1R and the activation of SP/NK ...
Xiangyu Hong +4 more
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Neurokinin-1 receptors on lumbar spinothalamic neurons in the rat
Neuroscience, 1996In order to determine whether spinothalamic neurons in the lumbar spinal cord of the rat process neurokinin-1 (substance P) receptors, we injected cholera toxin B subunit into the thalamus and carried out dual-labelling immunocytochemistry to search for neurons that were immunoreactive with antibodies to cholera toxin and neurokinin-1 receptor.
G E, Marshall +3 more
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Neurokinin 1 Receptor Antagonism as a Possible Therapy for Alcoholism
Science, 2008Alcohol dependence is a major public health challenge in need of new treatments. As alcoholism evolves, stress systems in the brain play an increasing role in motivating continued alcohol use and relapse. We investigated the role of the neurokinin 1 receptor (NK1R), a mediator of behavioral stress responses, in alcohol dependence ...
David T, George +14 more
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Purification and Reconstitution of a Recombinant Human Neurokinin-1 Receptor
Journal of Receptors and Signal Transduction, 1996Recombinant human neurokinin-1 receptors expressed in insect cells have been purified to near homogeneity by sequential metal-chelating chromatography and gel filtration chromatography. The purified receptor consists of a single polypeptide with an apparent molecular weight of 50 kD as revealed by SDS gel electrophoresis, and exhibits a specific ...
K E, Mazina +4 more
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Substance P and the Neurokinin-1 Receptor: The New CRF
2017Substance P (SP) is an 11-amino acid neuropeptide of the tachykinin family that preferentially activates the neurokinin-1 receptor (NK1R). First isolated 85 years ago and sequenced 40 years later, SP has been extensively studied. Early studies identified a role for SP and the NK1R in contraction of intestinal smooth muscle, central pain processing, and
Jesse R, Schank, Markus, Heilig
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Neurokinin receptor antagonism: a patent review (2014-present)
Expert Opinion on Therapeutic Patents, 2020Rafael Coveñas, MIGUEL Munoz
exaly
Neurokinin‐1 Receptors in the Human Eye
Annals of the New York Academy of Sciences, 1991G F, Kieselbach +5 more
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