Results 101 to 110 of about 12,085 (139)
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Internalization of the neurokinin 1 receptor in rat myenteric neurons
Neuroscience, 1999Immunoreactivity for the neurokinin 1 receptor is contained in nerve cell bodies that have been deduced to be intrinsic primary afferent neurons in the myenteric plexus of the rat ileum. This study shows that neurokinin 1 receptor immunoreactivity on these neurons represents receptors that can bind agonist and undergo endocytosis, and explores the ...
P T, Mann, B R, Southwell, J B, Furness
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Neurokinin 1 receptor isoforms and the control of innate immunity
Trends in Immunology, 2009Substance P is the prototype tachykinin peptide and triggers a variety of biological effects in both the nervous and immune system. Two naturally occurring variants of the neurokinin 1 receptor (NK1R) mediate the effects of SP: a 'classic' full-length receptor and a truncated (tail-less) form that lacks 96 amino acid residues at the C-terminus.
Florin, Tuluc +4 more
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Targeting Opioid and Neurokinin-1 Receptors to Treat Alcoholism
Current Medicinal Chemistry, 2011Alcoholism is a multifarious and ongoing disease tightly related to the amount of alcohol ingested, the drinking pattern, the history of alcohol drinking and the individual features, such as some genetic traits. Worldwide alcohol is the necessary cause of approximately 60 diseases and causes circa 2.5 million deaths every year.
F D, Rodriguez, R, Coveñas
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Neurokinin-1 receptors are decreased in major depressive disorder
Neuroreport, 2002Treatment with an antagonist at the neurokinin-1 (NK-1) receptor may alleviate depression, however the brain region(s) in which the NK-1 receptor antagonist exerts its therapeutic effect is unknown. [125I]BH-Substance P was used to measure NK-1 receptors postmortem in cytoarchitectonically defined areas of rostral orbitofrontal cortex (Brodmann's area ...
Craig A, Stockmeier +8 more
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Ontogeny of neurokinin-1 receptors in the porcine respiratory system
Peptides, 1999We characterized the ontogeny of NK-1 receptor agonist affinity (Kd) and density (Bmax) in membranes from tracheal epithelium, smooth muscle, and lung of pigs aged 1-7 days, 8-21 days, and adult in comparison to contractile responses in vitro. Affinity of [125I] Bolton-Hunter substance P ([125I]BH-SP) in epithelium and smooth muscle was three- to ...
M D, Yohannan +4 more
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Complex allosteric interaction of heparin with neurokinin-1 receptors
European Journal of Pharmacology: Molecular Pharmacology, 1991The effects of several heparin preparations on rat striatal neurokinin-1 receptor labelling were investigated. A low concentration of heparin dose-dependently stimulated [125I]Bolton-Hunter substance P ([125I]BH-SP) binding to rat striatal membranes. This effect was mainly due to an increase of the association velocity reflected by a decrease of the ...
G A, Knaus, H G, Knaus, A, Saria
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Substance P and the Neurokinin-1 Receptor: The New CRF
2017Substance P (SP) is an 11-amino acid neuropeptide of the tachykinin family that preferentially activates the neurokinin-1 receptor (NK1R). First isolated 85 years ago and sequenced 40 years later, SP has been extensively studied. Early studies identified a role for SP and the NK1R in contraction of intestinal smooth muscle, central pain processing, and
Jesse R, Schank, Markus, Heilig
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Association of Neurokinin-1 Receptor Signaling Pathways with Cancer
Current Medicinal ChemistryBackground: Numerous biochemical reactions leading to altered cell proliferation cause tumorigenesis and cancer treatment resistance. The mechanisms implicated include genetic and epigenetic changes, modified intracellular signaling, and failure of control mechanisms caused by intrinsic and extrinsic factors alone or combined.
Francisco David Rodriguez +1 more
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