Results 91 to 100 of about 12,085 (139)

Expression of the neurokinin 1 receptor in the rabbit retina

Neuroscience, 2002
Substance P is the preferred ligand for the neurokinin 1 (NK1) receptor. In vertebrate retinas, substance P is expressed by amacrine, interplexiform and ganglion cells. Substance P influences the activity of amacrine and ganglion cells and it is reported to evoke dopamine release.
CASINI, GIOVANNI, SABATINI A., CATALANI E., WILLEMS D., BOSCO L., BRECHA N. C.   +5 more
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A Novel Mechanism of Neurokinin-1 Receptor Resensitization

The Journal of Pharmacology and Experimental Therapeutics, 2002
Prolonged or repeated activation of many G protein-coupled receptors induces rapid desensitization followed by a period during which receptors are resensitized. In this study, concanavalin A (Con A) and monensin were used to investigate the mechanisms of desensitization and resensitization of the neurokinin-1 receptor.
V J, Bennett, S A, Perrine, M A, Simmons
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Expression of the neurokinin 1 receptor in the mouse retina

Neuroscience, 2004
Previous studies have revealed that the expression pattern of the neurokinin 1 receptor (the preferred receptor for substance P, SP) varies in different mammalian retinas. We investigated NK1 receptor expression in the mouse retina to provide background information for future studies in transgenic mice on SP functional roles in the retina.
CATALANI E, GANGITANO C, BOSCO L., CASINI, GIOVANNI   +3 more
openaire   +4 more sources

The Neurokinin-1 Receptor in Addictive Processes

The Journal of Pharmacology and Experimental Therapeutics, 2014
Stress can trigger drug-seeking behavior, increase self-administration rates, and enhance drug reward. A number of stress-related neuropeptides have been shown to mediate these behavioral processes. The most studied peptide in this category is corticotropin-releasing hormone (CRH), which has been shown to mediate stress-induced reinstatement of drug ...
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The substance P/neurokinin-1 receptor system in lung cancer: Focus on the antitumor action of neurokinin-1 receptor antagonists

Peptides, 2012
The last decades have seen no significant progress in extending the survival of lung cancer patients and there is an urgent need to improve current therapies. The substance P (SP)/neurokinin-1 receptor (NK-1R) system plays an important role in the development of cancer: SP and NK-1R antagonists respectively induce cell proliferation and inhibition in ...
Miguel, Muñoz, Ana, González-Ortega, Marisa, Rosso, María José, Robles-Frias, Andres, Carranza, Manuel Vicente, Salinas-Martín, Rafael, Coveñas   +6 more
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Regulation of neurokinin-1 receptor expression by GABAB receptor agonists

Life Sciences, 1998
Activation of GABA(B) receptors produces analgesia in acute and chronic pain models. Data indicate that a possible mechanism for this effect is a GABA(B) receptor-induced blockade of neurokinin-1 (NK-1) receptor gene expression in the spinal cord. While much more potent GABA(B) receptor agonists (CGP 44532) have been developed, there is no information ...
S J, Enna, E B, Harstad, K E, McCarson
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Substance P and neurokinin-1 receptor modulation of HIV

Journal of Neuroimmunology, 2004
There is a high incidence of life event stress, depression, and associated symptoms in individuals with HIV infection/AIDS. Psychological and psychiatric symptomatology in individuals with HIV and AIDS may be related to the progression of AIDS disease.
Wen-Zhe, Ho, Steven D, Douglas
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A selective and extremely potent antagonist of the neurokinin-1 receptor

Brain Research, 1992
Sendide [Tyr6,D-Phe7,D-His9]-substance P(6-11) has been examined by measurements of ligand binding to crude membrane fractions and by functional tests on the spinally mediated behavioral response. Sendide potently displaced [3H]-labeled substance P (SP) binding to mouse spinal cord membranes in a competitive manner.
T, Sakurada, Y, Manome, K, Tan-No, S, Sakurada, K, Kisara, M, Ohba, L, Terenius   +6 more
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Endocytosis and recycling of neurokinin 1 receptors in enteric neurons

Neuroscience, 1996
Neurotransmission depends on the availability of transmitter and on the presence of functional, high-affinity receptors at the plasma membrane that are capable of binding ligand. The pathway, mechanism and function of endocytosis and recycling of the substance P or neurokinin 1 receptor in enteric neurons were studied using fluorescent substance P ...
E F, Grady, P D, Gamp, E, Jones, P, Baluk, D M, McDonald, D G, Payan, N W, Bunnett   +6 more
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Evaluation of constrained amino acids in the design of neurokinin 1 receptor- and bifunctional opioid – neurokinin 1 receptor ligands

Pharmacological Reports, 2011
Background and Aim: Polypharmacology is generally possible in three ways: 1) drug cocktails, 2) multicomponent drugs and 3) multiple ligands. The first two methods show disadvantages like poor patient compliance and drug-drug interactions. Multiple ligands however, consisting of a single chemical entity that modulates multiple targets simultaneously ...
Steven Ballet, Lukasz Frankiewicz, Karel Guillemyn, Isabelle van den Eynde, Nga N. Chung, Attila Keresztes, Joost Van Duppen, Josephine Lai, Eva Varga, Frank Porreca, Peter W. Schiller, Jozef Vanden Broeck, Dirk Tourwé   +12 more
openaire   +3 more sources