Results 91 to 100 of about 440 (147)
Capsaicin-Mediated Neurogenic Vasodilatation in Neurokinin-1, NK1, Receptor Knockout Mice
The Scientific World Journal, 2001 A. D. Grant, S. D. Brain
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Neurokinin-1 receptors on the afferents to the raphe
, 2016 Hafizi, S +4 more
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Safety of neurokinin-1 receptor antagonists
Expert Opinion on Drug Safety, 2013The substance P (SP)/neurokinin (NK)-1 receptor system is involved in many pathological processes. NK-1 receptor antagonists have many promising therapeutic indications. However, the only NK-1 receptor antagonist used in clinical practice is the drug aprepitant and its intravenously administered prodrug, fosaprepitant.
Miguel, Muñoz, Rafael, Coveñas
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Neurokinin-1 Receptor Resensitization Precedes Receptor Recycling
The Journal of Pharmacology and Experimental Therapeutics, 2005Following agonist binding, neurokinin-1 receptors undergo rapid desensitization followed by internalization and recycling. Desensitization requires receptor phosphorylation but does not require internalization, whereas resensitization is thought to require internalization and recycling.
V J, Bennett, S A, Perrine, M A, Simmons
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Expression of the neurokinin 1 receptor in the rabbit retina
Neuroscience, 2002Substance P is the preferred ligand for the neurokinin 1 (NK1) receptor. In vertebrate retinas, substance P is expressed by amacrine, interplexiform and ganglion cells. Substance P influences the activity of amacrine and ganglion cells and it is reported to evoke dopamine release.
CASINI, GIOVANNI +5 more
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A Novel Mechanism of Neurokinin-1 Receptor Resensitization
The Journal of Pharmacology and Experimental Therapeutics, 2002Prolonged or repeated activation of many G protein-coupled receptors induces rapid desensitization followed by a period during which receptors are resensitized. In this study, concanavalin A (Con A) and monensin were used to investigate the mechanisms of desensitization and resensitization of the neurokinin-1 receptor.
V J, Bennett, S A, Perrine, M A, Simmons
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Expression of the neurokinin 1 receptor in the mouse retina
Neuroscience, 2004Previous studies have revealed that the expression pattern of the neurokinin 1 receptor (the preferred receptor for substance P, SP) varies in different mammalian retinas. We investigated NK1 receptor expression in the mouse retina to provide background information for future studies in transgenic mice on SP functional roles in the retina.
CATALANI E +3 more
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The Neurokinin-1 Receptor in Addictive Processes
The Journal of Pharmacology and Experimental Therapeutics, 2014Stress can trigger drug-seeking behavior, increase self-administration rates, and enhance drug reward. A number of stress-related neuropeptides have been shown to mediate these behavioral processes. The most studied peptide in this category is corticotropin-releasing hormone (CRH), which has been shown to mediate stress-induced reinstatement of drug ...
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Peptides, 2012
The last decades have seen no significant progress in extending the survival of lung cancer patients and there is an urgent need to improve current therapies. The substance P (SP)/neurokinin-1 receptor (NK-1R) system plays an important role in the development of cancer: SP and NK-1R antagonists respectively induce cell proliferation and inhibition in ...
Miguel, Muñoz +6 more
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The last decades have seen no significant progress in extending the survival of lung cancer patients and there is an urgent need to improve current therapies. The substance P (SP)/neurokinin-1 receptor (NK-1R) system plays an important role in the development of cancer: SP and NK-1R antagonists respectively induce cell proliferation and inhibition in ...
Miguel, Muñoz +6 more
openaire +2 more sources