Results 81 to 90 of about 440 (147)

Beyond Histamine: Mast Cell‐Neuron Communication in Chronic Pruritic and Pain Disorders

Experimental Dermatology, Volume 35, Issue 8, August 2026.
ABSTRACT Chronic pruritic and cutaneous pain disorders are increasingly recognized as neuroimmune conditions driven by dynamic interactions between immune and sensory systems. While histamine has historically dominated models of mast cell‐mediated itch, accumulating evidence indicates that non‐histaminergic pathways are central to chronic disease.
Tomer Kagan, Gil Yosipovitch
wiley   +1 more source

Physiological mechanisms and therapeutic targets in chronic cough

Physiological Reports, Volume 14, Issue 15, August 2026.
Abstract Cough is a vital defensive reflex that safeguards the airways; however, it can become maladaptive and pathological. Chronic cough (>8 weeks in duration) affects up to 10% of the global adult population and is associated with considerable health status impairment. The understanding of cough physiology remains limited.
James C. Brown, Katherine L. Rhatigan, Oliver J. Price, Peter S. P. Cho   +3 more
wiley   +1 more source

Neurokinin-1 receptor antagonists as antitumor drugs in gastrointestinal cancer: A new approach

The Saudi Journal of Gastroenterology, 2016
Gastrointestinal (GI) cancer is the term for a group of cancers affecting the digestive system. After binding to the neurokinin-1 (NK-1) receptor, the undecapeptide substance P (SP) regulates GI cancer cell proliferation and migration for invasion and ...
Miguel Muñoz, Rafael Coveñas
doaj   +1 more source

Neurokinin-1 receptor: neurokinin-1 receptor, purification and refolding

, 2012
El receptor Neuroquinin-1 (NK1R) és un GPCR que es troba en el sistema nerviós central i perifèric dels vertebrats i és responsable dels processos fisiològics com la transmissió de dolor, secreció endocrina i exocrina, vasodilatació, modulació de la proliferació cel·lular i molts altres.
openaire   +1 more source

Phase II study of pregabalin for the prevention of chemotherapy induced nausea and vomiting

O Mundo da Saúde
To evaluate the role of pregabalin in the protection of chemotherapy-induced nausea and vomiting, we performed a phase II randomized, double-blind, placebo-controlled trial to investigate whether pregabalin could improve the complete control of nausea ...
Carla Santos Rossi Paniquar, Auro del Giglio, Alayne Magalhães Trindade Domingues Yamada, Felipe José Silva Melo Cruz   +3 more
doaj   +1 more source

Exploring neurokinin-1 receptor antagonism for depression with structurally differentiated inhibitors

Experimental and Molecular Medicine
The neurokinin-1 receptor (NK1R) has been investigated as a potential target for major depressive disorder owing to its role in stress regulation and neuroinflammation.
Hyeijung Yoo, Kyung-Jun Boo, Lan Phuong Nguyen, Jong-Ik Hwang, Cheol Soon Lee, Soo Hyun Yang, Se Jin Jeon, Hong-Rae Kim, Hyun Kim   +8 more
doaj   +1 more source

Recent developments in the clinical pharmacology of rolapitant: subanalyses in specific populations

Drug Design, Development and Therapy, 2017
Bernardo Leon Rapoport,1 Matti Aapro,2 Martin R Chasen,3 Karin Jordan,4 Rudolph M Navari,5 Ian Schnadig,6 Lee Schwartzberg7 1The Medical Oncology Centre of Rosebank, Johannesburg, South Africa; 2Breast Center, Genolier Cancer Center, Genolier ...
Rapoport BL, Aapro M, Chasen MR, Jordan K, Navari RM, Schnadig I, Schwartzberg L   +6 more
doaj  

Diagnostic and Therapeutic Potential of Substance P/NK1 Receptor in Primary Dysmenorrhea: A Pilot Study

Health Science Reports
Background and Aims Primary dysmenorrhea is a prevalent condition that causes significant menstrual pain and discomfort, impacting many women′s daily activities.
Riffat Mehboob, Imran Shahid, Abdullah R. Alzahrani, Shimaa Mohammad Yousof, Hafsa Adnan, Samar N. Ekram, Ahmad Alwazzan, Hisham Nasief, Khalid A. Khadawardi   +8 more
doaj   +1 more source

Electroacupuncture on Baihui (DU20) and Xuehai (SP10) acupoints alleviates psoriatic inflammation by regulating neurotransmitter substance P- Neurokinin-1 receptor signaling

Journal of Traditional and Complementary Medicine
Background: At present, acupuncture-related practices have been widely used to treat psoriasis. In our study, we investigated the effect and explored the mechanism of electroacupuncture (EA) on acupoints Baihui (DU20) and Xuehai (SP10) for the treatment ...
Cong Qi, Fang Feng, JianNing Guo, Yu Liu, XiaoYao Guo, YuJiao Meng, TingTing Di, XueQing Hu, Yazhuo Wang, Ning Zhao, XiaWei Zhang, Yan Wang, Jingxia Zhao, Ping Li   +13 more
doaj   +1 more source

Recycling and Resensitization of the Neurokinin 1 Receptor [PDF]

Journal of Biological Chemistry, 2004
Dirk Roosterman, Graeme S. Cottrell, Fabien Schmidlin, Martin Steinhoff, Nigel W. Bunnett   +4 more
openaire   +1 more source