Results 51 to 60 of about 108,380,509 (205)

The Origins of Allergy: An Outside‐In, Bioenergetic Hypothesis

Allergy, EarlyView.
ABSTRACT Allergic disease has risen too rapidly for inherited susceptibility to explain it, and the risk variants so far reported lie in the epithelial barrier and in type‐2 immunity. We propose a five‐layer model in which epithelial barrier and bioenergetic dysfunction may precede and promote type‐2 immune deviation rather than arise solely as its ...
Peter K. Smith, Nicholas P. West, Stanley Du Preez, Hugh A. Sampson, Peter W. Hellings, David Price, Liam O'Mahony, Carina Venter, Cezmi A. Akdis, Gil Yosipovitch   +9 more
wiley   +1 more source

Neurokinin-1 receptor antagonists as antitumor drugs in gastrointestinal cancer: A new approach [PDF]

Saudi Journal of Gastroenterology, 2016
Gastrointestinal (GI) cancer is the term for a group of cancers affecting the digestive system. After binding to the neurokinin-1 (NK-1) receptor, the undecapeptide substance P (SP) regulates GI cancer cell proliferation and migration for invasion and metastasis, and controls endothelial cell proliferation for angiogenesis.
Muñoz, Miguel, Coveñas, Rafael
openaire   +4 more sources

Differential Gene Expression Profile in the Rat Caudal Vestibular Nucleus is Associated with Individual Differences in Motion Sickness Susceptibility. [PDF]

PLoS ONE, 2015
To identify differentially expressed genes associated with motion sickness (MS) susceptibility in the rat caudal vestibular nucleus.We identified MS susceptible (MSS) and insusceptible (inMSS) rats by quantifying rotation-induced MS symptoms: defecation ...
Jun-Qin Wang, Rui-Rui Qi, Wei Zhou, Yi-Fan Tang, Lei-Lei Pan, Yi-Ling Cai   +5 more
doaj   +1 more source

Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders

British Journal of Pharmacology, EarlyView.
Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman, Christopher J. Black, Andrea Shin, Daniel Keszthelyi   +3 more
wiley   +1 more source

Cytotoxic and apoptotic effects of neurokinin-1 receptor (NK1R) antagonist on multiple myeloma cells [PDF]

مجله علمی دانشگاه علوم پزشکی کردستان, 2019
Background and Aim: Despite therapeutic improvements in recent decades, multiple myeloma (MM) still remains as one of the leading causes of death all over the world. Previous studies have indicated role of neurokinin-1 receptor (NK1R) in the pathogenesis
Elham Razani, Davood Bashash
doaj   +1 more source

Investigation of the mechanisms and modulation of irinotecan‐induced emesis in Suncus murinus

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Irinotecan is a widely used chemotherapeutic agent that frequently causes nausea and emesis. Its emetic mechanism of action is poorly understood and the choice of drugs to reduce nausea and emesis is largely empirical. Experimental Approach Using Suncus murinus, we examined (i) the dose–response and temporal profile of ...
Zengbing Lu, Julia Y. H. Liu, Yasuhiro Nakagami, Zitong Li, Xiaofei Huang, Man P. Ngan, Dexuan Cui, John A. Rudd   +7 more
wiley   +1 more source

Activation of Spinal Cholecystokinin and Neurokinin-1 Receptors Is Associated With the Attenuation of Intrathecal Morphine Analgesia Following Electroacupuncture Stimulation in Rats

Journal of Pharmacological Sciences, 2007
We previously demonstrated that electroacupuncture (EA) stimulation both produced antinociception and attenuated intrathecal (i.t.) morphine analgesia, suggesting that EA is capable of inducing two opposing systems, that is, opioid and anti-opioid ...
Yohji Fukazawa, Takehiko Maeda, Norikazu Kiguchi, Kazuo Tohya, Michio Kimura, Shiroh Kishioka   +5 more
doaj   +1 more source

The Expression of Neuropeptides in Pulpitis: A Systematic Review and Meta‐Analysis

International Endodontic Journal, EarlyView.
ABSTRACT Background Neuropeptides play key roles in the inflammatory, nociceptive and reparative processes of the dental pulp. Their upregulation has been frequently observed in inflamed pulps, suggesting potential diagnostic value supporting a role for neurogenic inflammation in symptomatic irreversible pulpitis.
N. Watson, D. Edwards, Q. Vuong, I. Obara   +3 more
wiley   +1 more source

THE EFFICACY OF APREPITANT (NK-1 RECEPTOR ANTAGONIST) AS PROPHYLAXIS FOR POSTOPERATIVE NAUSEA AND VOMITING

Pakistan Armed Forces Medical Journal, 2020
Objective: To assess the effectiveness of Aprepitant (NK-1 receptor antagonist) for prophylaxis of postoperative nausea and vomiting in middle aged female patients undergoing laparoscopic cholecystectomy under General Anesthesia.
Muhammad Akram, Saleem Pervaiz Bajwa, Abdullah , Akhtar Hussain, C. Aqeel Safdar, Umer Khan   +5 more
doaj   +4 more sources

Orexin antagonism and substance-P: Effects and interactions on polycystic ovary syndrome in the wistar rats

Journal of Ovarian Research, 2023
Background Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder without definitive treatments. Orexin and Substance-P (SP) neuropeptides can affect the ovarian steroidogenesis.
Somayeh Kouhetsani, Homayoun Khazali, Hassan Rajabi-Maham   +2 more
doaj   +1 more source