Results 31 to 40 of about 108,380,509 (205)

Substance P selectively decreases paired pulse depression in the rat hippocampal slice

BMC Neuroscience, 2005
Background Although being widespread in the hippocampus, the role tachykinins play in synaptic transmission is unclear. The effect of substance P on field potentials evoked by stimulation of the Schaffer collateral-commissural fibres and recorded from ...
Davies Stephen N, Wease Kerrie N
doaj   +1 more source

Restoration of regulatory T-cell function in dry eye disease by antagonizing substance P/neurokinin-1 receptor [PDF]

, 2020
Substance P (SP) is a tachykinin neuropeptide, implicated in the pathogenesis of various inflammatory conditions and a critical mediator in pain transmission. Recently, the role of SP was described in the pathogenesis of dry eye disease (DED) through its
Taketani, Y., Amouzegar, A., Dohlman, T.H., Chen, Y.H., Chauhan, S.K., Singh, R.B., Dana, R., Marmalidou, A.   +7 more
core   +1 more source

Neurokinin-1 receptor antagonists in the prevention of postoperative nausea and vomiting [PDF]

British Journal of Anaesthesia, 2009
Despite major advances, emesis remains a major problem in the context of cancer chemotherapy and in the postoperative period. A better understanding of the relevant neurocircuitry, especially the central pattern generator responsible for emesis and the central role of substance P, led to the development of a new class of antiemetics: the neurokinin-1 ...
Diemunsch, P., Joshi, G. P., Brichant, Jean-François   +2 more
openaire   +2 more sources

Kisspeptin Restores Pulsatile LH Secretion in Patients with Neurokinin B Signaling Deficiencies:Physiological, Pathophysiological and Therapeutic Implications [PDF]

, 2012
Pulsatile gonadotropin-releasing hormone (GnRH) is crucial to normal reproductive function and abnormalities in pulse frequency give rise to reproductive dysfunction.
Young, Jacques, Millar, Robert, Brailly-Tabard, Sylvie, Guiochon-Mantel, Anne, Bouligand, Jerome, Millar, Robert P, George, Jyothis, Tello, Javier, Anderson, Richard, Francou, Bruno, Anderson, Richard A, George, Jyothis T, Tello, Javier A, Tello, Javier; id_orcid   +13 more
core   +1 more source

Effects of TAK-480, a Novel Tachykinin NK2–Receptor Antagonist, on Visceral Hypersensitivity in Rabbits and Ricinoleic Acid–Induced Defecation in Guinea Pigs

Journal of Pharmacological Sciences, 2012
TAK-480, 4-(difluoromethoxy)-N-((1R,2S)-2-(((3aR,4R,9bR)-4-(methoxymethyl)-2, 3,3a,4,5,9b-hexahydro-1H-pyrrolo[3,2-c]quinolin-1-yl)carbonyl)cyclohexyl)benzamide, is a novel tachykinin NK2–receptor antagonist.
Takahiro Tanaka, Akiko Tanaka, Akihiro Nakamura, Kozo Matsushita, Akio Imanishi, Shiho Matsumoto-Okano, Nobuhiro Inatomi, Kasei Miura, Masao Toyoda, Gaku Mizojiri, Yasuhiro Tsukimi   +10 more
doaj   +1 more source

Neurokinin-1 receptor is highly expressed in cervical cancer and its antagonist induces cervical cancer cell apoptosis

European Journal of Histochemistry, 2023
Neurokinin-1 receptor (NK1R) belongs to tachykinin receptor family. Recent studies have suggested that NK1R was upregulated in cancer tissues including breast cancer, glioma and melanoma.
Liyun Guan, Shifa Yuan, Jing Ma, Hong Liu, Lizhen Huang, Fengzhen Zhang   +5 more
doaj   +1 more source

Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography

Nature Communications, 2019
The FDA approved drug aprepitant is an antagonist of the Neurokinin 1 receptor (NK1R). Here the authors present aprepitant bound NK1R crystal structures and use NMR spectroscopy to gain further insights into the dynamics of aprepitant binding, which is ...
Shuanghong Chen, Mengjie Lu, Dongsheng Liu, Lingyun Yang, Cuiying Yi, Limin Ma, Hui Zhang, Qing Liu, Thomas M. Frimurer, Ming-Wei Wang, Thue W. Schwartz, Raymond C. Stevens, Beili Wu, Kurt Wüthrich, Qiang Zhao   +14 more
doaj   +1 more source

A novel super-potent neurokinin A receptor antagonist containing dehydroalanine.

, 1998
We report here the synthesis and preliminary pharmacological characterization of a novel Neurokinin A receptor antagonist. This molecule contains a dehydroalanine residue. It displays a high conformational rigidity and possesses very high activity.
FILIPPELLI, Amelia, V. Pavone, B. D'Agostino, M. Falciani, LOMBARDI, ANGELINA, A. Lombardi, L. D. D'Andrea, NASTRI, FLAVIA, F. Rossi, F. Nastri, L. D. DANDREA, A. FILIPPELLI, B. DAGOSTINO, PAVONE, VINCENZO, Rossi F, Filippelli A, Falciani M, Pavone, D'Agostino, D'Andrea, L D, V, Lombardi A, B Nastri F   +23 more
core   +1 more source

Overview of the neurokinin-1 receptor antagonists

Biotarget, 2017
Neurokinin-1 (NK-1) receptor antagonists block substance P-mediated NK-1 receptors which are present in the abdominal vagus, the brainstem, and the area postrema in the brainstem. Substance P is a mammalian tachykinin that is found in vagal afferent neurons innervating the brainstem and sends impulses to the vomiting center (1). Compounds that block NK-
openaire   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source