Results 11 to 20 of about 108,380,509 (205)
Neurokinin-1 Receptor Antagonist Treatment in Polymicrobial Sepsis: Molecular Insights [PDF]
International Journal of Inflammation, 2010 Neurokinin-1 receptor blocking has been shown to be beneficial against lung injury in polymicrobial sepsis. In this paper, we evaluated the possible mediators and the mechanism involved.
Akhil Hegde +3 more
doaj +4 more sources
The neurokinin 1 receptor antagonist, ezlopitant, reduces appetitive responding for sucrose and ethanol. [PDF]
PLoS ONE, 2010 The current obesity epidemic is thought to be partly driven by over-consumption of sugar-sweetened diets and soft drinks. Loss-of-control over eating and addiction to drugs of abuse share overlapping brain mechanisms including changes in motivational ...
Pia Steensland +5 more
doaj +3 more sources
NEUROGENIC MODULATION BY NEUROKININ-1 RECEPTOR ANTAGONIST, CP-96,345 TO INHIBIT RHEUMATOID ARTHRITIS DEVELOPMENT IN ADJUVANT INDUCED ARTHRITIS RAT MODEL [PDF]
Folia Medica Indonesiana, 2017 Rheumatoid arthritis (RA) is a chronic form of persistent inflammation. Meanwhile, Substance P is the most associated neuropeptide in neurogenic inflammation and hyperalgesia commonly found in chronic pain.
Yuyun Wirasasmita +3 more
doaj +3 more sources
Neurokinin-1 receptor activation in globus pallidus
Frontiers in Neuroscience, 2009 The undecapeptide substance P has been demonstrated to modulate neuronal activity in a number of brain regions by acting on neurokinin-1 receptors. Anatomical studies revealed a moderate level of neurokinin-1 receptor in rat globus pallidus. To determine
Lei Chen +4 more
doaj +2 more sources
Effect of montelukast on platelet activating factor- and tachykinin induced mucus secretion in the rat [PDF]
Journal of Occupational Medicine and Toxicology, 2008 Background Platelet activating factor and tachykinins (substance P, neurokinin A, neurokinin B) are important mediators contributing to increased airway secretion in the context of different types of respiratory diseases including acute and chronic ...
Groneberg David A +3 more
doaj +2 more sources
Therapeutic Advances in Respiratory Disease, 2009 Objective: We previously reported that the nonpeptide tachykinin NK 2 receptor antagonist SR48968 (saredutant) significantly inhibits neurokinin A-induced bronchoconstriction in patients with asthma. MEN11420 (nepadutant) is a bicyclic peptide tachykinin
Venessa Schelfhout +4 more
doaj +2 more sources
Involvement of Substance P and the Neurokinin-1 Receptor in Radiation-Induced Hair Loss in Mice
Journal of Pharmacological Sciences, 2010 We investigated the involvement of substance P (SP) and the neurokinin-1 receptor (NK1 R) in the development of radiation-induced hair loss in mice.
Kouichi Yamamoto +4 more
doaj +2 more sources
Neurokinin 1 Receptor Antagonists for Pruritus [PDF]
Drugs, 2021 Pruritus, commonly known as itch, is a very common symptom in numerous dermatological disorders and systemic diseases. It can manifest as acute, or when lasting longer than 6 weeks, it is considered chronic and can lead to significant distress and reduced quality-of-life of those suffering.
Majid Alam +3 more
openaire +2 more sources
Therapeutics and Clinical Risk Management, 2009 Christina Ruhlmann, Jørn HerrstedtOdense University Hospital, Department of Oncology, Odense, DenmarkAbstract: Chemotherapy-induced nausea and vomiting (CINV) are among the most feared and distressing symptoms experienced by patients with ...
Christina Ruhlmann +1 more
doaj +1 more source
Investigational New Drugs, 2018 The substance P/neurokinin-1 receptor system has been implicated in tumor cell proliferation. Neurokinin-1 receptor has been identified in different solid tumors but not frequently in hematopoietic malignant cells. We investigated the presence of the Neurokinin-1 receptor in acute myeloid leukemia cell lines (KG-1 and HL-60), demonstrating that acute ...
Molinos-Quintana, A. +6 more
openaire +4 more sources