Results 21 to 30 of about 108,380,509 (205)

Neurokinin-1 Receptor Antagonists against Hepatoblastoma [PDF]

Cancers, 2019
Hepatoblastoma (HB) is the most common malignant liver tumor that occurs during childhood. The prognosis of children with HB is favorable when a complete surgical resection of the tumor is possible, but for high-risk patients, the prognosis is much worse. New anti-HB strategies must be urgently developed.
Miguel Muñoz, Marisa Rosso, Rafael Coveñas   +2 more
openaire   +6 more sources

Efficacy of vestipitant, a neurokinin-1 receptor antagonist, in primary insomnia. [PDF]

Sleep, 2013
Investigate the hypnotic effects of repeated doses of neurokinin-1 receptor antagonist, vestipitant, in primary insomnia.Randomized, double-blind, placebo-controlled 28-day parallel-group study.Eleven sleep centers in Germany.One hundred sixty-one patients with primary insomnia.Patients received vestipitant (15 mg) or placebo for 28 days; 2-night ...
Ratti E, Carpenter DJ, Zamuner S, Fernandes S, Squassante L, Danker-Hopfe H, Archer G, Robertson J, Alexander R, Trist DG, Merlo-Pich E.   +10 more
europepmc   +4 more sources

Neurokinin 1 receptor antagonist along with dexamethasone reduces the inflammation in COVID-19 patients: a novel therapeutic approach [PDF]

, 2023
Background: Corona virus infection is a respiratory infection, compromising the normal breathing in critical patients by damaging the lungs. The aim of this study was to evaluate the clinical outcomes of Substance P receptor Neurokinin 1 antagonist in ...
Shahid, Imran, Mehboob, Riffat, Qayyum, Ahad, Ahmad, Fridon Jawad, Tamur, Shadi, Rana, Muhammad Asim, Abusikkuen, Samy A., Fathaddin, Amany, Mirza, Iman M, Zayed, Mohamed A, Tariq, Muhammad Akram   +10 more
core   +1 more source

Cerebral blood flow changes after treatment of social phobia with the neurokinin-1 antagonist GR205171, citalopram, or placebo

, 2005
BACKGROUND: Evidence is accumulating that pharmacological blockade of the substance P preferring neurokinin-1 (NK1) receptor reduces anxiety. This study compared the effects of an NK1 receptor antagonist, citalopram, and placebo on brain activity and ...
Zancan, Stefano, Pich, Emilio Merlo, Wahlstedt, Kurt, Appel, Lieuwe, Långström, Bengt, Grohp, Magnus, Nilsson, Lars-Göran, Åhs, Fredrik,, Flyckt, Karin, Bergstrom, Mats, Jacobsson, Eva, Furmark, Tomas,, Michelgård, Asa, Fredrikson, Mats, Bani, Massimo   +14 more
core   +8 more sources

Upregulation of substance P in low-threshold myelinated afferents is not required for tactile allodynia in the chronic constriction injury and spinal nerve ligation models [PDF]

, 2007
It has been proposed that substance P and calcitonin gene-related peptide (CGRP) are upregulated in low-threshold myelinated primary afferents after certain types of nerve injury, and that release of substance P from these afferents contributes to the ...
Todd, A.J., Riddell, J.S., Scott, D.T., Hughes, D.I.   +3 more
core   +2 more sources

Neurokinin‐1 receptor antagonists for the prevention of postoperative nausea and vomiting

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 2023
AbstractDespite the availability of several classes of antiemetics, postoperative nausea and vomiting (PONV) remains a substantial burden for patients following surgery, resulting in patient dissatisfaction and prolonged stays in post‐anesthesia care units and ultimately increasing the cost of care.
Tricia A. Meyer, Ashraf S. Habib, Deborah Wagner, Tong J. Gan   +3 more
openaire   +2 more sources

Hot flashes: Why? [PDF]

Romanian Medical Journal, 2021
Hot flashes (HF), transitory episodes of erythema, heat sensation, anxiety followed by chills, are described in carcinoid syndrome, mastocytosis, medullary thyroid cancer, hyperthyroidism, pheochromocytoma, alcohol consumption, side effects of drugs, and
Florica Sandru, Mihai Cristian Dumitrascu, Eugenia Petrova, Anda Dumitrascu, Claudiu Tupea, Mara Carsote, Adina Ghemigian, Ana Valea   +7 more
doaj   +1 more source

Effect of endogenous substance P on visceral afferent signal integration in the nucleus tractus solitaries of rat brainstem slices

IBRO Neuroscience Reports, 2023
In the first synapse of the blood-pressure-regulating pathway, a neurokinin (NK) family peptide substance P (SP) is release with an excitatory neurotransmitter, glutamate, to enhance the sensitivity of the baroreflex responses.
Zhenhua Jin, Jin-Bae Kim, Young-Ho Jin
doaj   +1 more source

Neurokinin-1 Receptor (NK-1R) Antagonists as a New Strategy to Overcome Cancer Resistance [PDF]

, 2022
SIMPLE SUMMARY: Improving the response, quality of life and survival of oncologic patients through the design and application of the most appropriate treatment for each case is a great scientific challenge.
Téllez, Teresa, Redondo-Bautista, Maximino, Teresa Téllez, Redondo, Maximino, McKenna, Lauraine, Marilina García-Aranda, Maximino Redondo, Téllez-Santana, Teresa, Lauraine McKenna, García Aranda, Marilina, García-Aranda, Marilina   +10 more
core   +1 more source

Neurokinin-1 receptor antagonists as novel antidepressants: trials and tribulations [PDF]

British Journal of Psychiatry, 2007
SummaryBased upon animal experiments and early clinical trials, neurokinin-1 receptor antagonists showed promise as novel antidepressants. Subsequently, however, more extensive clinical trials did not reveal evidence of efficacy in depression.
Hafizi, S, Chandra, P, Cowen, J
openaire   +3 more sources