Results 41 to 50 of about 108,380,509 (205)

Intrathecal neurokinin-1 receptor antagonist reduces isoflurane MAC in rats [PDF]

Canadian Journal of Anaesthesia, 1997
To study the effects of intrathecal administration of a neurokinin-I(NK-I) receptor antagonist (CP96,345) on the minimum alveolar anaesthetic concentration (MAC) of isoflurane in anaesthetized rats, and on the locomotive activity of conscious rats.Wistar rats (n = 36) were fitted with indwelling intrathecal catheters, and the MAC of isoflurane was ...
K, Ishizaki, S, Karasawa, K, Takahashi, M, Hasegawa, F, Goto   +4 more
openaire   +2 more sources

Neuronorm is a potent and water soluble neurokinin A receptor antagonist.

, 1998
We report here the synthesis and preliminary pharmacological characterization of a novel water soluble Neurokinin A receptor antagonist named Neuronorm.
FILIPPELLI, Amelia, C. Pedone, V. Pavone, B. D'Agostino, M. Falciani, LOMBARDI, ANGELINA, A. Lombardi, M. G. Matera, F. Rossi, M. De Rosa, A. FILIPPELLI, B. DAGOSTINO, PAVONE, VINCENZO, Mario De Rosa, Angela Lombardi, Carlo Pedone, Francesco Rossi, Bruno D'Agostino, Maddalena Falciani, Vincenzo Pavone, Amelia Filippelli, Maria Gabriella Matera   +21 more
core   +1 more source

Advent of NK3R Antagonists for the Treatment of Menopausal Hot Flushes: A Narrative Review

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT The menopause transition is marked by symptoms predominantly attributed to declining oestrogen levels. Approximately 80% of women experience associated symptoms, and 25% experience severe symptoms. The commonest are vasomotor symptoms (VMS), collectively referring to hot flushes and/or night sweats.
Aaran H. Patel, Aureliane Pierret, Edouard G. Mills, Alexander N. Comninos, Waljit S. Dhillo, Ali Abbara   +5 more
wiley   +1 more source

Conformational Rigidity Versus Flexibility in a Novel Peptidic Neurokinin A Receptor Antagonist

, 1995
Neurokinin A receptor antagonists have been proposed as a new class of drugs for several applications in humans (asthama, intestinal motility, etc.). The rational design, synthesis, structural characterization and biological activity evaluation of a new ...
L. QUARTARA, C. PEDONE, C. A. MAGGI, PAVONE, VINCENZO, LOMBARDI, ANGELINA   +4 more
core   +1 more source

Modern Management of the Menopause: Are We Measuring What Matters?

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective Assess uptake of the Core Outcomes in Menopause (COMMA) core outcome sets (COS) and examine whether frontline treatments for vasomotor and genitourinary symptoms have been evaluated against these key outcomes. Design Methodological review. Setting Published literature and international clinical trial registries.
Joscelyn Gan, Michelle Steeper, Tim Hillard, Monica Christmas, Jan Shifren, Nick Panay, Martha Hickey, Sarah Lensen   +7 more
wiley   +1 more source

Comparative Efficacy of Elinzanetant Versus Other Non‐Hormonal Pharmaceutical Therapies for the Treatment of Moderate‐to‐Severe Vasomotor Symptoms Associated With Menopause: A Network Meta‐Analysis

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Background Elinzanetant, a novel, dual neurokinin‐targeted therapy, has been approved in various geographies for the treatment of moderate‐to‐severe vasomotor symptoms (VMS) associated with menopause. Objective To compare the efficacy of elinzanetant with non‐hormonal pharmaceutical treatments (nHT) in alleviating VMS.
Piotr Wojciechowski, Klaudia Kolonko, Andromachi Giannopoulou, Beata Smela, Elżbieta Olewinska, Kristina Rosa Bolling, Jenifer Sassarini, Lee P. Shulman, Vikram Talaulikar   +8 more
wiley   +1 more source

Contribution of Histamine to Nociceptive Behaviors Induced by Intrathecally Administered Cholecystokinin-8

Frontiers in Pharmacology, 2020
The involvement of spinal release of histamine in the nociceptive behaviors induced by cholecystokinin-8 (CCK-8) was investigated in mice. Intrathecal (i.t.) injection of CCK-8 elicited the nociceptive behaviors consisting of biting and licking.
Takafumi Hayashi, Chizuko Watanabe, Soh Katsuyama, Yasuyuki Agatsuma, Damiana Scuteri, Giacinto Bagetta, Tsukasa Sakurada, Shinobu Sakurada   +7 more
doaj   +1 more source

Systemic Therapy Management Strategies for Early‐Stage Breast Cancer in Australia

Asia-Pacific Journal of Clinical Oncology, EarlyView.
Advances in systemic therapy for early‐stage breast cancer in Australia highlight genomic‐guided decisions, subtype‐specific strategies, and emerging targeted and immunotherapies, shaping personalized and de‐escalated treatment approaches. ABSTRACT Breast cancer is the most common cancer among Australian women, with early‐stage disease (Stages I, II ...
Nicholas Zdenkowski, Rachel Dear, Sanjeev Kumar, Hilary Martin, Dhanusha Sabanathan, Stephen J. Luen, Belinda Yeo   +6 more
wiley   +1 more source

Neurokinin-1 receptor antagonist R116301 inhibits substance P-induced venodilation.

, 1999
OBJECTIVE To test the effect of the neurokinin-1 receptor antagonist hydroxybutanedioate (R116301) in human hand veins in vivo. METHODS In a randomized, double-blind, placebo-controlled crossover study we used the hand vein compliance method to ...
Linder L, Haefeli WE, Romerio SC
core   +1 more source

Structures of neurokinin 1 receptor in complex with Gq and Gs proteins reveal substance P binding mode and unique activation features [PDF]

, 2021
The neurokinin 1 receptor (NK1R) is involved in inflammation and pain transmission. This pathophysiologically important G protein–coupled receptor is predominantly activated by its cognate agonist substance P (SP) but also by the closely related ...
Schöppe, Jendrik; https://orcid.org/, Plückthun, Andreas; https://orcid.org/, Thom, Cristian; https://orcid.org/, Waltenspühl, Yann; https://orcid.org/, Vacca, Santiago; https://orcid.org/, Medalia, Ohad; https://orcid.org/, Ehrenmann, Janosch; https://orcid.org/, Yann Waltenspühl, Janosch Ehrenmann, Santiago Vacca, Andreas Plückthun, Cristian Thom, Ohad Medalia, Jendrik Schöppe   +13 more
core   +1 more source