Neurokinin-1 Receptor Resensitization Precedes Receptor Recycling
, 2020 Following agonist binding, neurokinin-1 receptors undergo rapid desensitization followed by internalization and recycling. Desensitization requires receptor phosphorylation but does not require internalization, whereas resensitization is thought to ...
V J Bennett, S A Perrine, M A Simmons
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Spotlight on the perioperative use of maropitant citrate
Veterinary Medicine: Research and Reports, 2017 Bonnie L Hay Kraus Department of Veterinary Clinical Sciences, Iowa State University College of Veterinary Medicine, Ames, IA, USA Abstract: Neurokinin-1 (NK-1) receptors are present in both the central nervous system and peripheral tissues. Substance P (
Hay Kraus BL
doaj
Molecular mechanisms of mast cells in mediating heart failure
Frontiers in ImmunologyCardiac mast cells have emerged as mechanistically versatile and clinically consequential mediators of heart failure and cardiomyopathy, acting through a diverse arsenal of preformed granule constituents, de novo synthesized lipid mediators, cytokines ...
Letao Zhou, Yifei Li, Peng Yue
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, 2016 A stepwise chemical modification from human neurokinin-3 receptor (hNK-3R)-selective antagonists to potent and combined hNK-3R and hNK-2R antagonists using the same 2-phenylquinoline template is described.
Luca F. Raveglia (2497237) +16 more
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[Neurokinin-1 receptor antagonists for postoperative nausea and vomiting: a systematic review and meta-analysis]. [PDF]
Braz J Anesthesiol, 2020 Murakami C +10 more
europepmc +1 more source
Prevention of acute chemotherapy-induced nausea and vomiting: the role of palonosetron
Cancer Management and Research, 2009 Emilio Bajetta, Sara Pusceddu, Valentina Guadalupi, Monika Ducceschi, Luigi CelioMedical Oncology Unit 2, Fondazione IRCCS “Istituto Nazionale dei Tumori”, Milan, ItalyAbstract: Prevention of nausea and vomiting is the main goal of ...
Emilio Bajetta +3 more
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Internalization of the neurokinin 1 receptor in rat myenteric neurons
, 1999 Internalization of the neurokinin 1 receptor in rat myenteric ...
BR Southwell (14473155) +2 more
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Purinergic receptor expression in neuronal, bladder smooth muscle and urothelial cells: characterization and inhibition by low molecular weight antagonists [PDF]
, 2009 P2 purinoceptors comprise ionotropic (P2X) and metabotropic (P2Y) receptor families, responsive to nucleotide ligands and diversely distributed on virtually every mammalian cell. Most cells and tissues co-express multiple subtypes of purinoceptor; thus,
Gever, J.L.
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In Silico Study of Neurokinin-1 Receptor Antagonists by QSAR Modeling
, 2017 QSAR studies were performed on a series neurokinin-1 receptor. neurokinin-1 receptor have been analyzed in relation to their physicochemical and molecular properties. On the basis of QSAR studies presented here, the coefficients of Id, IOR, MR, MW, ST, MV, Pz are positive and therefore it may be suggested that denser, bulkier, more polar substituents ...
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Neurokinin 1 and 2 Receptors Mediate Cholera Toxin Secretion in Rat Jejunum
, 2020 Background & Aims: Substance P, a member of the tachykinin family, is a prosecretory neuropeptide distributed widely throughout the enteric nervous system. Implicated in inflammatory states, its role in enterotoxigenic water and electrolyte secretion
James L Turvill +2 more
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