Results 91 to 100 of about 108,375,652 (210)

Research progress in therapeutic drugs for chemotherapy-induced nausea and vomiting

Zhongguo linchuang yanjiu
"Chemotherapy-induced nausea and vomiting（CINV）is a common adverse reaction in tumor treatment,which seriously affects patients􀆳 quality of life and treatment compliance.
WANG Jin,HAN Jiapeng,LI Ying,WANG Jirong
doaj   +1 more source

Exploring neurokinin-1 receptor antagonism for depression with structurally differentiated inhibitors

Experimental and Molecular Medicine
The neurokinin-1 receptor (NK1R) has been investigated as a potential target for major depressive disorder owing to its role in stress regulation and neuroinflammation.
Hyeijung Yoo, Kyung-Jun Boo, Lan Phuong Nguyen, Jong-Ik Hwang, Cheol Soon Lee, Soo Hyun Yang, Se Jin Jeon, Hong-Rae Kim, Hyun Kim   +8 more
doaj   +1 more source

Aprepitant and Fosaprepitant for Preventing Nausea and Vomiting in Patients Receiving Highly Emetogenic Chemotherapy—A Real-World Study

Current Oncology
Chemotherapy-induced nausea and vomiting substantially impair patients’ quality of life despite considerable advances in supportive care. Neurokinin-1 receptor antagonists, including oral aprepitant and intravenous fosaprepitant, constitute essential ...
Beyza Ünlü, Hacer Demir, Sena Ece Davarcı, Yaşar Culha, Duygu Özaşkın, Fariz Emrah Özkan, Sedat Yıldız, Canan Yıldız, Meltem Baykara   +8 more
doaj   +1 more source

Perioperative uses of histamine antagonists [PDF]

, 1990
Histamine release and adverse pseudoallergic/allergic reactions during the perioperative period occur frequently. The incidence of such reactions is 20%-30% for all grades of severity, 1%-5% for systemic reactions, and 0.1%-0.5% for life-threatening ...
Lorenz, Wilfried, Doenicke, A., Ennis, M., Dick, W., Wolfgang Dick, Madeleine Ennis, Wilfried Lorenz, Alfred Doenicke   +7 more
core   +1 more source

A New Hope for Woman with Vasomotor Symptoms: Neurokinin B Antagonists

KNDy (kisspeptine, neurokinin B, dynorphin) neurons, located in the hypothalamus, play a crucial role in the development of vasomotor symptoms (VSM) in menopausal women.
Christian Unogu, Stefania Bochynska, Anna Kostrzak, Marzena Maciejewska-Jeske, Blazej Meczekalski, Anna Szeliga, Gregory Bala   +6 more
core   +1 more source

Treatment-resistant prurigo nodularis: challenges and solutions

Clinical, Cosmetic and Investigational Dermatology, 2019
Eric H Kowalski,1 Diana Kneiber,1 Manuel Valdebran,2 Umangi Patel,1 Kyle T Amber1 1Department of Dermatology, University of Illinois at Chicago, Chicago, IL, USA; 2Department of Dermatology, University of California, Irvine, Irvine, CA, USA Abstract ...
Kowalski EH, Kneiber D, Valdebran M, Patel U, Amber KT   +4 more
doaj  

New tachykinin peptides and nociception

Japanese Dental Science Review, 2013
Hemokinin-1 (HK-1) and endokinins are peptides predicted from a new mammalian tachykinin gene, TAC4. The amino acid sequences derived from rat/mouse HK-1 and human HK-1 are not identical; however, the effects induced by intracerebroventricular or ...
Toshikazu Nishimori, Rumi Naono-Nakayama, Tetsuya Ikeda   +2 more
doaj   +1 more source

Computational Analysis of the Neurokinin-1 Receptor Interactions with Antagonists [PDF]

Biophysical Journal, 2021
Marcelo Cardoso dos, Reis Melo, Cesar de, la Fuente-Nunez   +3 more
openaire   +1 more source

Profile of netupitant/palonosetron (NEPA) fixed dose combination and its potential in the treatment of chemotherapy-induced nausea and vomiting (CINV)

Drug Design, Development and Therapy, 2014
Rudolph M Navari Cancer Care Program, Eastern Europe, World Health Organization, Mishawaka, IN, USA; Indiana University School of Medicine, South Bend, IN, USA; South Bend Medical Services Corporation, IN, USA Abstract: Chemotherapy-induced ...
Navari RM
doaj  

Challenges in the Development of Intravenous Neurokinin-1 Receptor Antagonists: Results of a Safety and Pharmacokinetics Dose-Finding, Phase 1 Study of Intravenous Fosnetupitant. [PDF]

Clin Pharmacol Drug Dev, 2022
Tyler T, Schultz A, Venturini A, Giuliano C, Bernareggi A, Spezia R, Voisin D, Stella V.   +7 more
europepmc   +1 more source