Results 71 to 80 of about 108,375,652 (210)
Journal of Ovarian Research, 2023 Background Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder without definitive treatments. Orexin and Substance-P (SP) neuropeptides can affect the ovarian steroidogenesis.
Somayeh Kouhetsani +2 more
doaj +1 more source
Journal of Small Animal Practice, EarlyView.Objectives Chronic idiopathic rhinitis is a common canine nasal disease with unknown aetiology and poor response to treatment. Neurokinin‐1 receptor activation has been associated with rhinitis in experimental animals. The aim of this pilot study was to compare the effects of oral neurokinin‐1 receptor antagonist (maropitant) with placebo on clinical ...
H. Neittaanmäki +4 more
wiley +1 more source
Microvascular endothelial function is blunted in postmenopausal females with frequent hot flushes
Experimental Physiology, EarlyView.Abstract Hot flushes of menopause are associated with elevated blood pressure (BP) and diminished macrovascular endothelial function, an initiating factor in the onset of atherosclerosis. Whether microvascular endothelial function is impaired in females with hot flushes, however, remains unknown.
William Stokes +9 more
wiley +1 more source
, 2016 Constrained systematic search was used in an exhaustive conformational analysis of a structurally diverse set of substance P (SP) antagonists to identify a unique hypothesis for their bound conformation at the neurokinin-1 receptor. In this conformation,
Yasuo Takeuchi (2323159) +3 more
core +2 more sources
Neurokinin-1 Receptor Antagonist Treatment in Polymicrobial Sepsis: Molecular Insights
International Journal of Inflammation, 2010 Neurokinin-1 receptor blocking has been shown to be beneficial against lung injury in polymicrobial sepsis. In this paper, we evaluated the possible mediators and the mechanism involved. Mice were subjected to cecal ligation and puncture (CLP-) induced sepsis or sham surgery. Vehicle or SR140333 [1 mg/kg; subcutaneous (s.c.)] was administered to septic
Akhil Hegde +3 more
openaire +3 more sources
High‐altitude headache: Insights into pathophysiology and potential treatment implications
The Journal of Physiology, EarlyView.Abstract figure legend High‐altitude headache occurs during prolonged exposure to low oxygen, such as during ascent to high altitude. Several risk factors increase its likelihood, with the degree of hypoxia, often driven by rapid ascent to greater altitudes, being the most prominent factor.
Marika Falla +3 more
wiley +1 more source
Pregabalin Efficacy in Treatment of Chronic Neurogenic Cough
The Laryngoscope, Volume 136, Issue 11, Page 4938-4944, November 2026.The use of neuromodulators for chronic cough has increased; however, the choice of medication, dosing regimen, and duration are still unclear. This longitudinal study of 95 adults taking pregabalin, 75 mg twice daily, for CNC demonstrated 78% improvement or resolution of cough, 17% unchanged, 1% worse cough, with a mean of 6 weeks of therapy, and only ...
Jacqui Allen +3 more
wiley +1 more source
Neurokinin 1/3 Receptor Antagonists for Vasomotor Symptoms in Women with Breast Cancer
healthbook TIMES. Oncology HematologyEndocrine therapy remains a cornerstone treatment for patients with hormone receptor-positive breast cancer. However, its benefits are often undermined by treatment-related adverse events, including vasomotor symptoms (VMS) such as hot flashes and night ...
Michael Gnant +2 more
doaj +1 more source
Journal of Internal Medicine, Volume 300, Issue 5, Page 590-609, November 2026.Abstract Polyendocrine metabolic ovarian syndrome (PMOS), previously known as polycystic ovary syndrome, affects 10%–13% of women of reproductive age and remains underdiagnosed despite its substantial health burden. The introduction of the new PMOS nomenclature in 2026 reflects a fundamental shift in understanding the condition as a lifelong endocrine ...
Maria Forslund +5 more
wiley +1 more source
International Journal of Cancer, Volume 159, Issue 8, Page 1990-2003, 15 October 2026.Chemotherapy‐induced nausea and vomiting (CINV) remains a significant clinical problem despite modern antiemetics. In particular, antiemetic strategies for emerging cancer therapies lack detailed evaluation. This randomized trial analyzed hourly CINV data for patients with early breast cancer who received either docetaxel plus cyclophosphamide (TC) or ...
Manuel Hörner +16 more
wiley +1 more source