Results 81 to 90 of about 108,375,652 (210)

Discovery of a Novel Class of Selective Non-Peptide Antagonists for the Human Neurokinin-3 Receptor. 1. Identification of the 4-Quinolinecarboxamide Framework

, 2016
A novel class of potent and selective non-peptide neurokinin-3 (NK-3) receptor antagonists, featuring the 4-quinolinecarboxamide framework, has been designed based upon chemically diverse NK-1 receptor antagonists.
Andrew D. Medhurst (1845643), Luca F. Raveglia (2497237), Giuseppe A. M. Giardina (2497261), Douglas W. P. Hay (3011631), Roberto Rigolio (3018672), Henry M. Sarau (2353933), Mario Grugni (3011637), Vittorio Vecchietti (3018675), Mark Luttmann (3019941), Dulcie B. Schmidt (3018678), Carlo Farina (3011643)   +10 more
core   +1 more source

Building a Framework for Sexual and Reproductive Health Care in the Rheumatology Context: Content and Approaches

Arthritis Care &Research, Volume 78, Issue 10, Page 1510-1521, October 2026.
People with systemic autoimmune and rheumatic diseases (SARDs) are at higher risk than the general population of experiencing adverse pregnancy and perinatal outcomes such as preeclampsia, intrauterine growth restriction, and maternal and/or fetal death.
Mehret Birru Talabi, Sonya Borrero
wiley   +1 more source

Recent developments in the clinical pharmacology of rolapitant: subanalyses in specific populations

Drug Design, Development and Therapy, 2017
Bernardo Leon Rapoport,1 Matti Aapro,2 Martin R Chasen,3 Karin Jordan,4 Rudolph M Navari,5 Ian Schnadig,6 Lee Schwartzberg7 1The Medical Oncology Centre of Rosebank, Johannesburg, South Africa; 2Breast Center, Genolier Cancer Center, Genolier ...
Rapoport BL, Aapro M, Chasen MR, Jordan K, Navari RM, Schnadig I, Schwartzberg L   +6 more
doaj  

Chronic Prurigo of Nodular Type: A Review

Acta Dermato-Venereologica, 2017
Prurigo nodularis (PN) is a subtype of chronic prurigo presenting single to multiple symmetrically distributed, hyperkeratotic and intensively itching papules and nodules.
Claudia Zeidler, Athanasios Tsianakas, Manuel Pereira, Hartmut Ständer, Gil Yosipovitch, Sonja Ständer   +5 more
doaj   +1 more source

A New Generation of Treatments for Itch

Acta Dermato-Venereologica, 2020
For decades, antihistamines have been the mainstay of treatment for chronic pruritus, yet they often only work by making patients drowsy and forgetful of their itch.
Emilie Fowler, Gil Yosipovitch
doaj   +1 more source

Neuropeptide signaling through neurokinin-1 and neurokinin-2 receptors augments antigen presentation by human dendritic cells [PDF]

, 2015
Background: Neurotransmitters, including substance P (SP) and neurokinin A (NKA), are widely distributed in both the central and peripheral nervous system and their receptors, neurokinin-1 receptor (NK1R) and neurokinin-2 receptor (NK2R), are expressed ...
Ohtake, Junya, Shinya Tanaka, Ohno, Yosuke, Kaneumi, Shun, Kentaro Sumida, Toshiyuki Kita, Tanino, Yoshinori, Masuko, Kazutaka, Tanino, Mishie, Junya Ohtake, Tamiko Takemura, Kita, Toshiyuki, Toshiya Shinohara, Yosuke Ohno, Takuto Kishikawa, Hiroya Kobayashi, Sadahiro Iwabuchi, Shinohara, Toshiya, Yoshinori Tanino, Kobayashi, Hiroya, Hidemitsu Kitamura, Kitamura, Hidemitsu, Shun Kaneumi, Sumida, Kentaro, Terada, Satoshi, Kishikawa, Takuto, Kazutaka Masuko, Satoshi Terada, Takemura, Tamiko, Mishie Tanino, Iwabuchi, Sadahiro, Tanaka, Shinya   +31 more
core   +1 more source

Increased neurogenesis and brain-derived neurotrophic factor in neurokinin-1 receptor gene knockout mice [PDF]

, 2003
It has previously been shown that chronic treatment with antidepressant drugs increases neurogenesis and levels of brain-derived neurotrophic factor in the hippocampus.
Sheasby, Anne M., Peters, Marco, Moss, Andrew, Mantyh, Patrick W., Hunt, Stephen P., Harris, Elizabeth A., Giese, K. Peter, De Felipe, Carmen, Morcuende, Sara, Gadd, Christopher A., Rupniak, Nadia M. J., Fisher, Amy S.   +11 more
core   +1 more source

Use of NK₁ receptor antagonists in the exploration of physiological functions of substance P and neurokinin A

, 1995
Tachykinin NK1 receptor antagonists were used to explore the physiological functions of substance P (SP) and neurokinin A (NKA). Pharmacological profiles of three NK1 receptor antagonists, GR71251, GR82334, and RP 67580, were examined in the isolated ...
K. Yoshioka, T. Kurihara, M. Yanagisawa, J.-Z. Guo, H. Suzuki, R. Hosoki, M. Qtsuka, F.-Y. Zhao   +7 more
core   +1 more source

Neurokinin 1/3 Receptor Antagonists For Menopausal Women: A Current Systematic Review and Insights Into The Investigational Non-Hormonal Therapy

, 2023
This project involves a comprehensive systematic review of the current evidence on neurokinin 1/3 (NK1/3) receptor antagonists as a potential non-hormonal therapy for menopausal women.
Zouina Sarfraz
core   +1 more source

Neurokinin-1 Receptor Antagonists as a Potential Novel Therapeutic Option for Osteosarcoma Patients. [PDF]

J Clin Med, 2023
Robinson P, Rosso M, Muñoz M.
europepmc   +1 more source