Results 101 to 110 of about 108,375,652 (210)

Skin codelivery of contact sensitizers and neurokinin-1 receptor antagonists integrated in microneedle arrays suppresses allergic contact dermatitis. [PDF]

J Allergy Clin Immunol, 2022
Bandyopadhyay M, Morelli AE, Balmert SC, Ward NL, Erdos G, Sumpter TL, Korkmaz E, Kaplan DH, Oberbarnscheidt MH, Tkacheva O, Shufesky WJ, Falo LD, Larregina AT.   +12 more
europepmc   +1 more source

Projection neurons in lamina III of the rat spinal cord are selectively innervated by local dynorphin-containing excitatory neurons [PDF]

, 2012
Large projection neurons in lamina III of the rat spinal cord that express the neurokinin 1 receptor are densely innervated by peptidergic primary afferent nociceptors and more sparsely by low-threshold myelinated afferents. However, we know little about
Todd, A.J., Polgar, Erika, Furuta, T., Watanabe, M., Baseer, N., Todd, A., Kaneko, T.   +6 more
core   +1 more source

IUPHAR review: Navigating the role of preclinical models in pain research

Pharmacological Research
Chronic pain is a complex and challenging medical condition that affects millions of people worldwide. Understanding the underlying mechanisms of chronic pain is a key goal of preclinical pain research so that more effective treatment strategies can be ...
Seyed Asaad Karimi, Fatama Tuz Zahra, Loren J. Martin   +2 more
doaj   +1 more source

Liver Safety of the Dual Neurokinin-1/-3 Receptor Antagonist Elinzanetant

Drug Safety
Elinzanetant is a selective dual neurokinin (NK)-1/-3 receptor antagonist for the treatment of moderate-to-severe vasomotor symptoms associated with menopause or caused by endocrine therapy. Elinzanetant has been approved by health authorities in several countries.
James H. Lewis, Raúl J. Andrade, Dominique Larrey, Yves Horsmans, Richard A. Anderson, Mila Trajanovic, Esther Groettrup-Wolfers, Lineke Zuurman   +7 more
openaire   +3 more sources

Papel do receptor ativado por proteinases-2 (par-2) no comportamento de coçar em camundongos [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pos-Graduação em Farmacologia, Florianópolis, 2009.O objetivo do presente estudo foi investigar os possíveis mecanismos e mediadores envolvidos no
Costa, Robson da
core  

Optimization of Novel Antagonists to the Neurokinin‑3 Receptor for the Treatment of Sex-Hormone Disorders (Part II)

, 2015
Further lead optimization on N-acyl-triazolopiperazine antagonists to the neurokinin-3 receptor (NK3R) based on the concurrent improvement in bioactivity and ligand lipophilic efficiency (LLE) is reported.
Graeme L. Fraser (1372140), Julien Korac (1372152), Mohamed El Bousmaqui (1372158), François Lenoir (1372137), Sophie Noël (1372143), Alexey Lapin (1372149), Guillaume Dutheuil (1372155), Hamid R. Hoveyda (1372146)   +7 more
core   +1 more source

Neurokinin-1 receptor-based bivalent drugs in pain management: The journey to nowhere?

, 2018
Hybrid compounds (also known as chimeras, designed multiple ligands, bivalent compounds) are chemical units where two active components, usually possessing affinity and selectivity for distinct molecular targets, are combined as a single chemical entity.
Hermans, Emmanuel, Nowicka, Katarzyna, Bujalska-Zadrozny, Magdalena, Kleczkowska, Patrycja   +3 more
core   +1 more source

Dronabinol for chemotherapy-induced nausea and vomiting unresponsive to antiemetics

Cancer Management and Research, 2016
Megan Brafford May,1 Ashley E Glode2 1Department of Pharmacy, Baptist Health Lexington, Lexington, KY, USA; 2Department of Clinical Pharmacy, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus ...
May MB, Glode AE
doaj  

Discovery of Indazoles as Potent, Orally Active Dual Neurokinin 1 Receptor Antagonists and Serotonin Transporter Inhibitors for the Treatment of Depression

, 2016
Combination studies of neurokinin 1 (NK1) receptor antagonists and serotonin-selective reuptake inhibitors (SSRIs) have shown promise in preclinical models of depression. Such a combination may offer important advantages over the current standard of care.
Yi Hsiao (771103), David A. Conlon (1748254), Kevin W. Gillman (2292967), Joanna Hu (3225312), Jung-Hui Sun (1551394), Huiping Zhang (135186), Andrew P. Degnan (1445947), Michael K. Wong (646399), Hong Huang (119275), Amy E. Newton (3017022), Joseph Raybon (1399387), Joanne J. Bronson (1445890), Sarah J. Taylor (3225306), Nicholas J. Lodge (2252563), Umesh M. Hanumegowda (1445941), Rick L. Pieschl (3225318), Matthew T. Taber (2252554), Xiaoping Hou (3225315), Rudolph Krause (3225309), Carl D. Davis (1822078), Yu-Wen Li (1445905), John E. Macor (1399363), George O. Tora (3225303), Thorsten Rosner (1504984)   +23 more
core   +1 more source

Neurokinin 1 receptor antagonists in the prevention of chemotherapy-induced nausea and vomiting: focus on fosaprepitant

, 2018
Chemotherapy-induced nausea and vomiting (CINV) remains a challenge in cancer care. Improved understanding of CINV pathophysiology has triggered the development of new antiemetic therapeutic options, such as selective neurokinin-1 (NK1) receptor ...
Bernardo L Rapoport, Cindy Weinstein, Karin Jordan   +2 more
core   +1 more source