Results 171 to 180 of about 11,252 (195)

Central pressor actions of neurokinin B: increases in neurokinin B contents in discrete nuclei in spontaneously hypertensive rats

Brain Research, 1989
The regional distributions of neurokinin B-like immunoreactivity and substance P-like immunoreactivity in the central nervous system in spontaneously hypertensive rats (SHRs) and normotensive Wistar Kyoto rats (WKYs) were examined. The distribution of neurokinin B-like immunoreactivity in WKYs was not exactly the same as that of substance P-like ...
A, Nagashima, Y, Takano, K, Tateishi, Y, Matsuoka, T, Hamaoka, H, Kamiya   +5 more
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Clinical Translational Studies of Kisspeptin and Neurokinin B

Seminars in Reproductive Medicine, 2019
AbstractKisspeptin and neurokinin B (NKB) are hypothalamic neuropeptides that are vital for reproductive health. An absence of either kisspeptin or NKB signaling results in hypogonadotrophic hypogonadism and a failure to proceed through puberty. In recent years, several studies have demonstrated potential avenues for the clinical utility of medications
Tia, Hunjan, Ali, Abbara
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Distribution of neurokinin A-like and neurokinin B-like immunoreactivity in human peripheral tissues

Regulatory Peptides, 1991
Using specific radioimmunoassay and immunocytochemistry for neurokinin A (NKA) and neurokinin B (NKB), distribution and localization of the two peptides in human peripheral tissues were studied. Both NKA-like immunoreactivity (NKA-LI) and NKB-like immunoreactivity (NKB-LI) were present in the walls of the gut and gall bladder and in the pancreas.
S, Kishimoto, K, Tateishi, H, Kobayashi, K, Kobuke, T, Hagio, Y, Matsuoka, G, Kajiyama, A, Miyoshi   +7 more
openaire   +2 more sources

The role of neurokinin B in pre-eclampsia

Hospital Medicine, 2001
Pre-eclampsia, a life-threatening disease unique to pregnancy, has been called a disease of theories. To date, there has been no widely accepted predictive test or therapeutic intervention to prevent or delay pre-eclampsia. The discovery of a new placental hormone, neurokinin B, may finally help to answer some of the past mysteries.
N M, Page, P J, Lowry
openaire   +2 more sources

[The structure-function organization of neurokinin A and neurokinin B molecules. II. Theoretical conformational analysis of neurokinin B].

Biofizika, 2005
The spatial structure of a neurokinin B molecule was investigated by the method of theoretical conformational analysis. The conformational analysis of this molecule indicated that the possible structure of neurokinin B under polar conditions may be described by five families of low-energy conformations possessing a conformationally relatively rigid C ...
G A, Agaeva, N N, Kerimli, N M, Godzhaev
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Effect of kassinin, neurokinin A and neurokinin B on drinking behaviour in the pigeon

Regulatory Peptides, 1987
Intracerebroventricular (i.c.v.) injection of kassinin produced a prompt and copious drinking response at doses of 10-1000 ng/pigeon, in the absence of other behavioural alterations or of changes in core temperature. Neurokinin A and B evoked drinking, but they were respectively 10 and 100 times less potent than kassinin.
MASSI, Maurizio, PERFUMI, Marina Cecilia, POLIDORI, Carlo, de Caro G.   +3 more
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Stimulation of Cl Secretion by Neurokinin A and Neurokinin B in Canine Tracheal Epithelium

American Review of Respiratory Disease, 1988
We studied the effects of neurokinin A (NKA) and neurokinin B (NKB), the mammalian-derived tachykinins, on the electrical and ion transport properties of canine tracheal epithelium. Both tachykinins dose-dependently increased short-circuit current (Isc) when added to the mucosal (NKA: delta Isc(max) = 24.2 +/- 2.4 microA/cm2, KD = 9 nM; NKB: delta Isc ...
J, Tamaoki, I F, Ueki, J H, Widdicombe, J A, Nadel   +3 more
openaire   +2 more sources

Placental Neurokinin B mRNA Expression Increases at Preterm Labor

Placenta, 2007
Neurokinin B (NKB) is a neuropeptide belonging to the family of tachykinins-related peptides that elicits contractility of human myometrial strips in vitro. The present study evaluates whether placental mRNA and peptide expression of NKB change in women at preterm labor.A group of 26 women with singleton pregnancies were enrolled in the study ...
Torricelli, M., GIOVANNELLI, ANDREA, Leucci, E., Florio, P., De Falco, G., Torres, P. B., Reis, F. M., Leoncini, L., Petraglia, F.   +8 more
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Neurokinin B and Its Receptor in Hypogonadotropic Hypogonadism

2010
The hypothalamus integrates multiple environmental and developmental cues relevant to reproductive function, serving to transduce these into a pulsatile output of gonadotropin-releasing hormone (GnRH). Although neuroanatomical and physiological studies have yielded key clues about the functional organisation of the so-called 'GnRH pulse generator ...
Robert K, Semple, A Kemal, Topaloglu
openaire   +2 more sources

Kisspeptin and neurokinin B: roles in reproductive health

Physiological Reviews
Kisspeptin and neurokinin B (NKB) play a key role in several physiological processes including in puberty, adult reproductive function including the menstrual cycle, as well as mediating the symptoms of menopause. Infundibular kisspeptin neurons, which coexpress NKB, regulate the activity of gonadotropin-releasing hormone (GnRH) neurons and thus the ...
Kanyada Koysombat, Jovanna Tsoutsouki, Aaran H. Patel, Alexander N. Comninos, Waljit S. Dhillo, Ali Abbara   +5 more
openaire   +2 more sources