Results 171 to 180 of about 8,760 (227)
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Cysteinyldopamine is not incorporated into neuromelanin
Neuroscience Letters, 1991The pigment of human substantia nigra, neuromelanin, has been thought to be derived from dopamine. To examine the genesis of neuromelanin, we advanced a new hypothesis that neuromelanin is formed by oxidation of dopamine and cysteinyldopamine. On the basis of this hypothesis, synthetic neuromelanins were obtained by tyrosinase oxidation of dopamine in ...
Kazumasa Wakamatsu +2 more
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Neuromelanin as a nidus for neurodegeneration
Brain, 2023This scientific commentary refers to ‘Neuromelanin accumulation drives endogenous synucleinopathy in non-human primates’ by Chocarro et al. (https://doi.org/10.1093/brain/awad331).
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Neuromelanin: A Key to Parkinson's Disease
Pigment Cell Research, 1993Neuromelanin and its relation to Parkinson's disease are ...
Prota G, d'Ischia M
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Neuromelanin in manganese-exposed primates
Toxicology Letters, 1980Monkeys developed muscular weakness and rigidity of the lower limbs after 18 months exposure to manganese. These are neurological signs typical of chronic manganese intoxication. Marked neuronal degeneration with depigmentation was noticed in the region of substantia nigra.
S K, Gupta, R C, Murthy, S V, Chandra
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The neuromelanin of the human substantia nigra
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1991The pigment of the human substantia nigra was isolated after extraction of lipids and proteins with 2% sodium cholate in 30% ethanol followed by 2% sodium dodecyl sulfate in 10% glycerol. The pigment was hydrolysed with HI or degraded by treatment with KMNO4 and the samples were examined for compounds known to derive from pheomelanin (4-amino-3 ...
R, Carstam +4 more
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On the function of neuromelanin
Proceedings of the Royal Society of London. Series B: Biological Sciences, 1996The hypothesis is presented, based on the chemical structure of neuromelanin, that one of its functions in the catecholamine neurons in the brain is to protect the cell against toxic quinones (such as dopaminchrome and noradrenochrome, or their dihydroxy isomers) produced from the catecholamines dopamine and noradrenaline (and possibly adrenaline ...
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2006
The massive, early and relatively circumscribed death of the dopaminergic neurons of the substantia nigra in Parkinson's disease has not yet been adequately explained. The characteristic feature of this brain region is the presence of neuromelanin pigment within the vulnerable neurons.
K L, Double, G M, Halliday
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The massive, early and relatively circumscribed death of the dopaminergic neurons of the substantia nigra in Parkinson's disease has not yet been adequately explained. The characteristic feature of this brain region is the presence of neuromelanin pigment within the vulnerable neurons.
K L, Double, G M, Halliday
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Neuromelanin in parkinsonian disorders: an update
International Journal of Neuroscience, 2017Neuromelanin (NM) is a dark pigment that accumulates linearly with aging in substantia nigra (SN) and locus coeruleus (LC). The dual protective and toxic role of NM has been hypothesized according to its intraneuronal or extraneuronal deposition. The melanized dopaminergic neurons in SN and LC seem to have special vulnerability to neurodegeneration in ...
Martin-bastida, Antonio +2 more
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Toxicity of a serotonin-derived neuromelanin
Biochemical and Biophysical Research Communications, 2010Postoperative Cognitive Dysfunction (POCD) is associated with increased mortality in the elderly and may occur from lipid peroxidation in aging. We previously showed that sevoflurane sequesters acrolein, which promotes the formation of a novel species of a putative neuromelanin.
Elizabeth D, Miller +2 more
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Investigation of the lipid component of neuromelanin
Journal of Neural Transmission, 2006Neuromelanin (NM) is different to other melanins in that its ultrastructure includes a lipid component. The objectives of this study were to identify and quantify lipids associated with NM.Quantification of the lipid component associated with the pigment on electron micrographs demonstrated that this component comprises 35% of the NM granule volume in ...
H, Fedorow +8 more
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