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Isolation of Neuromelanin Granules
Current Protocols in Cell Biology, 2008AbstractNeuromelanin granules are pigmented organelles in the human midbrain that give name to a brain area, substantia nigra pars compacta, which macroscopically appears as a dark brown region in the midbrain due to the insoluble pigment neuromelanin.
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Neuromelanin of the Human Substantia Nigra: An Update
Neurotoxicity Research, 2013Dopaminergic neurons of the substantia nigra selectively degenerate over the course of Parkinson's disease. These neurons are also the most heavily pigmented cells of the brain, accumulating the dark pigment neuromelanin over a lifetime. The massive presence of neuromelanin in these brain areas has long been suspected as a key factor involved in the ...
Fabio A Zucca +2 more
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NEUROMELANIN AND NEURODEGENERATION
2019ABSTRACT The goal of this review was to explore the structure and function of neuromelanin and the role it plays in homeostasis and neurodegeneration by consolidating and synthesizing published scientific information in this area. This paper gives an overview of both healthy neuromelanin function and pathological neurodegenerative processes ...
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Decreased nigral neuromelanin in Alzheimer's disease
Neurological Research, 2003Using manual morphometric techniques, we estimated the amount of neuromelanin in hematoxylin and eosin-stained sections of the pars compacta of the substantia nigra of 19 Alzheimer's patients without nigral Lewy bodies and 12 age-matched controls. Our estimates showed that the mean area and areal fraction of neuromelanin were lower in Alzheimer's ...
Marc G, Reyes +3 more
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Neuromelanin, Neuroleptics and Schizophrenia
Neuropsychobiology, 1980On the assumption that neuromelanin content might be a parameter indicating neuronal activity in the catecholaminergic system, neuromelanin was measured microspectro-photometrically in the substantia nigra and the locus ceruleus of 12 brains of patients who had undergone neuroleptic therapy. Neuromelanin increased with age in both regions of 40 control
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Neuromelanin and RNA in Cells of Substantia Nigra
Journal of Neuropathology & Experimental Neurology, 1977We have found that with accumulation of neuromelanin granules within cell bodies of neurones of the human substantia nigra there is a reduction in cytoplasmic RNA and a decrease in nucleolar volume. These observations imply a gradual decrease in the functional capacity of the cell such that eventually, the cell is unable to produce sufficient protein ...
D M, Mann, P O, Yates, C M, Barton
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Structure and Function of Neuromelanin
2002Why is the structure of neuromelanin important? It has been known for many years that neuromelanin is present in the dopaminergic neurons of the substantia nigra and may be associated with the pathogenesis of nigral cell death in the Parkinson’s disease. Recently, it was shown that the vulnerability of the dopaminergic neurons in Parkinson’s disease is
Shosuke Ito +2 more
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Neuromelanin and Parkinson's disease.
Journal of neural transmission. Supplementum, 1984Neuromelanin is closely linked to Parkinson's disease, but is it the cause of the illness? The main pathology of Parkinson's disease is a loss of pigmented brain-stem neurones, and neuromelanin or its precursors might be cytotoxic. However, the cellular marker of Parkinsonian pathology, the Lewy body, is not confined to neurones containing neuromelanin.
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