Results 41 to 50 of about 100,070 (325)

Activity-dependent plasticity of transmitter release from nerve terminals in rat fast and slow muscles [PDF]

, 2018
Available under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported license.Peer reviewedPublisher ...
Bewick, Guy Smith, Lomo, T., Martinov, V. N., Nja, A., Reid, Brian   +4 more
core   +1 more source

Systematic review of mitochondrial dysfunction and oxidative stress in aging: A focus on neuromuscular junctions

Neural Regeneration Research
Mitochondrial dysfunction and oxidative stress are widely regarded as primary drivers of aging and are associated with several neurodegenerative diseases.
Senlin Chai, Ning Zhang, Can Cui, Zhengyuan Bao, Qianjin Wang, Wujian Lin, Ronald Man Yeung Wong, Sheung Wai Law, Rebecca Schönmehl, Christoph Brochhausen, Wing Hoi Cheung   +10 more
doaj   +1 more source

Monte Carlo simulation with fixed steplength for diffusion processes in nonhomogeneous media [PDF]

, 2013
Monte Carlo simulation is one of the most important tools in the study of diffusion processes. For constant diffusion coefficients, an appropriate Gaussian distribution of particle's steplengths can generate exact results, when compared with integration ...
Hoyuelos, Miguel Luis, Martin, Hector Omar, Ruiz Barlett, María Virginia   +2 more
core   +1 more source

Modulation of Microglia by Voluntary Exercise or CSF1R Inhibition Prevents Age-Related Loss of Functional Motor Units

Cell Reports, 2019
Summary: Age-related loss of skeletal muscle innervation by motor neurons leads to impaired neuromuscular function and is a well-established clinical phenomenon. However, the underlying pathogenesis remains unclear. Studying mice, we find that the number
Elisa Giorgetti, Moh Panesar, Yunyu Zhang, Stefanie Joller, Marie Ronco, Michael Obrecht, Christian Lambert, Nathalie Accart, Nicolau Beckmann, Arno Doelemeyer, Ludovic Perrot, Isabelle Fruh, Matthias Mueller, Eliane Pierrel, Serge Summermatter, Michael Bidinosti, Derya R. Shimshek, Sophie Brachat, Mark Nash   +18 more
doaj   +1 more source

SnapShot: Neuromuscular Junction

Cell, 2011
Agrin MuSK Dok-7Rapsyn AChR AChE ChAT Nav1.4Auto-antibodiesto AChRsAuto-antibodiesto MuSKHypomorphic mutations in thesegenes impair postsynaptic differentiation. The number of AChRs at synapses is reduced, which compromises the reliability of synaptic transmission and leads to muscle weakness and fatigue.
openaire   +2 more sources

Review: Dystroglycan in the Nervous System [PDF]

, 2007
Dystroglycan is part of a large complex of proteins, the dystrophin-glycoprotein complex, which has been implicated in the pathogenesis of muscular dystrophies for a long time.
Matthias Samwald
core   +2 more sources

Decreased Serum 5‐HT: Clinical Correlates and Regulatory Role in NMJ of MG

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although 5‐Hydroxytryptamine (5‐HT) indirectly stimulates muscle contraction and participates in regulating Acetylcholine receptor (AChR) cluster homeostasis in cellular, animal, and clinical studies, evidence regarding its potential to modulate muscle contraction in myasthenia gravis (MG) remains limited.
Xinru Shen, Jing Zhang, Xinyue Zhou, Xiaoxiao Yu, Haodong Shang, Shufan Chen, Lulu Zhen, Jinru Wu, Guanlian Hu, Xiaoyan Zhu, Zhan Sun, Yiren Wang, Jiahui Wang, Jie Lv, Xue Zhao, Yingna Zhang, Wei Guo, Ying Peng, Feng Gao   +18 more
wiley   +1 more source

Glutamate at the Vertebrate Neuromuscular Junction: From Modulation to Neurotransmission

Cells, 2019
Although acetylcholine is the major neurotransmitter operating at the skeletal neuromuscular junction of many invertebrates and of vertebrates, glutamate participates in modulating cholinergic transmission and plastic changes in the last.
Maria Nicol Colombo, Maura Francolini
doaj   +1 more source

Neurohormonal modulation of the Limulus heart: amine actions on neuromuscular transmission and cardiac muscle [PDF]

, 1985
The responses of Limulus cardiac neuromuscular junctions and cardiac muscle cells to four endogenous amines were determined in order to identify the cellular targets underlying amine modulation of heartbeat amplitude.
Augustine, George J., Colburne, J., Hoshi, T., Watson, Winsor H., III   +3 more
core   +1 more source

Facilitatory actions of guanidine on synaptic transmission in mammalian brain slices [PDF]

, 1979
Guanidine administration may be beneficial in the treatment of amyotrophic lateral sclerosis and related diseases; however, the actions of guanidine on the mammalian central nervous system have not been investigated.
Galvan, Martin, Grafe, Peter, Ten Bruggencate, Gerrit   +2 more
core   +1 more source