Results 51 to 60 of about 615,784 (234)

Factors that affect the onset of action of non-depolarizing neuromuscular blocking agents [PDF]

Korean Journal of Anesthesiology, 2017
Neuromuscular blockade plays an important role in the safe management of patient airways, surgical field improvement, and respiratory care. Rapid-sequence induction of anesthesia is indispensable to emergency surgery and obstetric anesthesia, and its ...
Yong Byum Kim, Tae-Yun Sung, Hong Seuk Yang   +2 more
doaj   +1 more source

A synaptic nidogen: Developmental regulation and role of nidogen-2 at the neuromuscular junction

Neural Development, 2008
Background The skeletal neuromuscular junction is a useful model for elucidating mechanisms that regulate synaptogenesis. Developmentally important intercellular interactions at the neuromuscular junction are mediated by the synaptic portion of a basal ...
Smyth Neil, Ho Matthew SP, Fox Michael A, Sanes Joshua R   +3 more
doaj   +1 more source

Schwann Cells in Neuromuscular Junction Formation and Maintenance

Journal of Neuroscience, 2016
The neuromuscular junction (NMJ) is a tripartite synapse that is formed by motor nerve terminals, postjunctional muscle membranes, and terminal Schwann cells (TSCs) that cover the nerve-muscle contact. NMJ formation requires intimate communications among
Arnab Barik, Lei Li, Anupama Sathyamurthy, W. Xiong, L. Mei   +4 more
semanticscholar   +1 more source

Motoneuron Wnts regulate neuromuscular junction development

eLife, 2018
The neuromuscular junction (NMJ) is a synapse between motoneurons and skeletal muscles to control motor behavior. Unlike extensively investigated postsynaptic differentiation, less is known about mechanisms of presynaptic assembly.
Chengyong Shen, Lei Li, Kai Zhao, Lei Bai, Ailian Wang, Xiaoqiu Shu, Yatao Xiao, Jianmin Zhang, Kejing Zhang, Tiankun Hui, Wenbing Chen, Bin Zhang, Wei Hsu, Wen-Cheng Xiong, Lin Mei   +14 more
doaj   +1 more source

Neuromuscular Junction Impairment in Amyotrophic Lateral Sclerosis: Reassessing the Role of Acetylcholinesterase

Frontiers in Molecular Neuroscience, 2016
Amyotrophic Lateral Sclerosis (ALS) is a highly debilitating disease caused by progressive degeneration of motorneurons (MNs). Due to the wide variety of genes and mutations identified in ALS, a highly varied etiology could ultimately converge to produce
María-Letizia Campanari, M. García‐Ayllón, S. Ciura, J. Sáez-Valero, E. Kabashi   +4 more
semanticscholar   +1 more source

Electrophysiological study in neuromuscular junction disorders

Annals of Indian Academy of Neurology, 2013
This review is on ultrastructure and subcellular physiology at normal and abnormal neuromuscular junctions. The clinical and electrophysiological findings in myasthenia gravis, Lambert-Eaton myasthenic syndrome (LEMS), congenital myasthenic syndromes ...
Ajith Cherian, Neeraj N Baheti, Thomas Iype   +2 more
doaj   +1 more source

Beneficial impacts of neuromuscular electrical stimulation on muscle structure and function in the zebrafish model of Duchenne muscular dystrophy

eLife, 2022
Neuromuscular electrical stimulation (NMES) allows activation of muscle fibers in the absence of voluntary force generation. NMES could have the potential to promote muscle homeostasis in the context of muscle disease, but the impacts of NMES on diseased
Elisabeth A Kilroy, Amanda C Ignacz, Kaylee L Brann, Claire E Schaffer, Devon Varney, Sarah S Alrowaished, Kodey J Silknitter, Jordan N Miner, Ahmed Almaghasilah, Tashawna L Spellen, Alexandra D Lewis, Karissa Tilbury, Benjamin L King, Joshua B Kelley, Clarissa A Henry   +14 more
doaj   +1 more source

Receptor subunit compositions underly distinct potencies of a muscle relaxant in fast and slow muscle fibers

Frontiers in Physiology, 2022
A line of studies in the 1960s–1980s suggested that muscle relaxants do not work uniformly on all skeletal muscles, though its mechanism has not been clarified.
Manami Yamashita, Yoshihiro Egashira, Shuntaro Nakamura, Souhei Sakata, Fumihito Ono   +4 more
doaj   +1 more source

Neuromuscular junction degeneration in muscle wasting

Current opinion in clinical nutrition and metabolic care, 2016
Purpose of reviewDenervation is a hallmark of age-related and other types of muscle wasting. This review focuses on recent insights and current viewpoints regarding the mechanisms and clinical relevance of maintaining the neuromuscular junction to ...
R. Rudolf, M. Deschenes, M. Sandri
semanticscholar   +1 more source

Moving forward with the neuromuscular junction [PDF]

Journal of Neurochemistry, 2017
AbstractThe neuromuscular junction (NMJ) is indispensable for survival. This synapse between motoneurons and skeletal muscle fibers allows posture, movement and respiration. Therefore, its dysfunction creates pathologies than can be lethal. The molecular mechanisms of NMJ development and maintenance are the subject of intensive studies.
Legay, Claire, Mei, Lin
openaire   +3 more sources