Results 11 to 20 of about 49,589 (307)
Nature Communications, 2023 The complex neuromuscular network that controls body movements is the target of severe diseases that result in paralysis and death. Here, we report the development of a robust and efficient self-organizing neuromuscular junction (soNMJ) model from human ...
Alessia Urzi +13 more
doaj +2 more sources
Inherited Neuromuscular Disorders: Which Role for Serum Biomarkers?
Brain Sciences, 2021 Inherited neuromuscular disorders (INMD) are a heterogeneous group of rare diseases that involve muscles, motor neurons, peripheral nerves or the neuromuscular junction.
Antonino Lupica +9 more
doaj +1 more source
Classical and Unexpected Effects of Ultra-Micronized PEA in Neuromuscular Function
Biomolecules, 2022 Recently, the endocannabinoid system has attracted growing attention from the scientific community for its involvement in homeostatic and pathological processes as they pertains to human physiology.
Pierangelo Cifelli +6 more
doaj +1 more source
A functional motor unit in the culture dish : co-culture of spinal cord explants and muscle cells [PDF]
, 2012 Human primary muscle cells cultured aneurally in monolayer rarely contract spontaneously because, in the absence of a nerve component, cell differentiation is limited and motor neuron stimulation is missing(1). These limitations hamper the in vitro study
Arnold, Anne-Sophie +2 more
core +1 more source
Motor endplate disease affects neuromuscular junction maturation [PDF]
European Journal of Neuroscience, 2012 AbstractPostnatal formation of the neuromuscular synapse requires complex interactions among nerve terminal, muscle fibres and terminal Schwann cells. In motor endplate disease (med) mice, neuromuscular transmission is severely impaired without alteration of axonal conduction and a lethal paralytic phenotype occurs during the postnatal period.
Caillol, Ghislaine +5 more
openaire +3 more sources
Autoimmune Channelopathies at Neuromuscular Junction
Frontiers in Neurology, 2019 The neuromuscular junction, also called myoneural junction, is a site of chemical communication between a nerve fiber and a muscle cell. There are many types of channels at neuromuscular junction that play indispensable roles in neuromuscular signal ...
Kun Huang +3 more
doaj +1 more source
Measuring neuromuscular junction functionality [PDF]
, 2017 Neuromuscular junction (NMJ) functionality plays a pivotal role when studying diseases in which the communication between motor neuron and muscle is impaired, such as aging and amyotrophic lateral sclerosis (ALS).
Del Prete, Zaccaria +4 more
core +1 more source
The importance of early diagnosis and treatment in treatable neuromuscular diseases
Chinese Journal of Contemporary Neurology and Neurosurgery, 2018 Neuromuscular diseases represent a heterogeneous group of disorders involving peripheral nerves, neuromuscular junction (NMJ) and skeletal muscle. The most common symptoms are muscular weakness and amyotrophy in different body parts to varying degrees ...
Cheng ZHANG, Yu-ling ZHU
doaj +1 more source
Bap1/SMN axis in Dpp4+ skeletal muscle mesenchymal cells regulates the neuromuscular system
JCI Insight, 2022 The survival of motor neuron (SMN) protein is a major component of the pre-mRNA splicing machinery and is required for RNA metabolism. Although SMN has been considered a fundamental gene for the central nervous system, due to its relationship with ...
Ji-Hoon Kim +14 more
doaj +1 more source
ATP Released by Injured Neurons Activates Schwann Cells [PDF]
, 2016 Injured nerve terminals of neuromuscular junctions (NMJs) can regenerate. This remarkable and complex response is governed by molecular signals that are exchanged among the cellular components of this synapse: motor axon nerve terminal (MAT ...
Cesare eMontecucco +8 more
core +2 more sources