Results 41 to 50 of about 49,589 (307)

Profile of sugammadex for reversal of neuromuscular blockade in the elderly: Current perspectives [PDF]

, 2017
The number of elderly patients is increasing worldwide. This will have a significant impact on the practice of anesthesia in future decades. Anesthesiologists must provide care for an increasing number of elderly patients, who have an elevated risk of ...
Bertoncello, Francesco, Carron, Michele, Ieppariello, Giovanna   +2 more
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New Therapeutics Options for Pediatric Neuromuscular Disorders

Frontiers in Pediatrics, 2020
Neuromuscular disorders (NMDs) of Childhood onset are a genetically heterogeneous group of diseases affecting the anterior horn cell, the peripheral nerve, the neuromuscular junction, or the muscle.
Marina Flotats-Bastardas, Andreas Hahn
doaj   +1 more source

A multilevel screening pipeline in zebrafish identifies therapeutic drugs for GAN

EMBO Molecular Medicine, 2023
Giant axonal neuropathy (GAN) is a fatal neurodegenerative disorder for which there is currently no treatment. Affecting the nervous system, GAN starts in infancy with motor deficits that rapidly evolve toward total loss of ambulation.
Léa Lescouzères, Cédric Hassen‐Khodja, Anaïs Baudot, Benoît Bordignon, Pascale Bomont   +4 more
doaj   +1 more source

Murine muscle stem cell response to perturbations of the neuromuscular junction are attenuated with aging

eLife, 2021
During aging and neuromuscular diseases, there is a progressive loss of skeletal muscle volume and function impacting mobility and quality of life. Muscle loss is often associated with denervation and a loss of resident muscle stem cells (satellite cells
Jacqueline A Larouche, Mahir Mohiuddin, Jeongmoon J Choi, Peter J Ulintz, Paula Fraczek, Kaitlyn Sabin, Sethuramasundaram Pitchiaya, Sarah J Kurpiers, Jesus Castor-Macias, Wenxuan Liu, Robert Louis Hastings, Lemuel A Brown, James F Markworth, Kanishka De Silva, Benjamin Levi, Sofia D Merajver, Gregorio Valdez, Joe V Chakkalakal, Young C Jang, Susan V Brooks, Carlos A Aguilar   +20 more
doaj   +1 more source

Synaptic actions of amyotrophic-lateral-sclerosis-associated G85R-SOD1 in the squid giant synapse [PDF]

, 2020
© The Author(s), 2020. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Song, Y.
Song, Yuyu
core   +1 more source

Facilitatory actions of guanidine on synaptic transmission in mammalian brain slices [PDF]

, 1979
Guanidine administration may be beneficial in the treatment of amyotrophic lateral sclerosis and related diseases; however, the actions of guanidine on the mammalian central nervous system have not been investigated.
Galvan, Martin, Grafe, Peter, Ten Bruggencate, Gerrit   +2 more
core   +1 more source

Neuromuscular Active Zone Structure and Function in Healthy and Lambert-Eaton Myasthenic Syndrome States

Biomolecules, 2022
The mouse neuromuscular junction (NMJ) has long been used as a model synapse for the study of neurotransmission in both healthy and disease states of the NMJ.
Scott P. Ginebaugh, Yomna Badawi, Tyler B. Tarr, Stephen D. Meriney   +3 more
doaj   +1 more source

Congenital myasthenic syndrome in Golden Retrievers is associated with a novel COLQ mutation. [PDF]

, 2020
BackgroundCongenital myasthenic syndromes (CMSs) are a group of inherited disorders of neuromuscular transmission that may be presynaptic, synaptic, or postsynaptic.
Anderson, Kendall J, Clark, Leigh Anne, Evans, Jacquelyn M, Guo, Ling T, Knipe, Marguerite, Shelton, G Diane, Sturges, Beverly K, Tsai, Kate L, Vernau, Karen M, Williams, D Colette, Winger, Kathryn, Zwueste, Danielle M   +11 more
core  

Agrin binds to the nerve-muscle basal lamina via laminin [PDF]

, 1997
Agrin is a heparan sulfate proteoglycan that is required for the formation and maintenance of neuromuscular junctions. During development, agrin is secreted from motor neurons to trigger the local aggregation of acetylcholine receptors (AChRs) and other ...
Altschul, Bowe, Bowe, Bowen, Brancaccio, Brandenberger, Brandenberger, Brubacher, Burden, Burgeson, Campagna, Campanelli, Campbell, Chiu, Cohen, Cohen, Denzer, Denzer, Ferns, Fox, Gautam, Gee, Gesemann, Gesemann, Gluzman, Godfrey, Godfrey, Godfrey, Godfrey, Graham, Hagen, Halfter, Hall, Hunter, Kleinman, Lennon, Lowry, Magill-Solc, Martin, Martin, McMahan, McMahan, Morrissey, Nitkin, Nitkin, Noakes, Ott, Paulsson, Pearson, Perris, Reist, Ries, Ruegg, Ruegg, Ruegg, Rupp, Sanes, Sanes, Sanes, Schuler, Smith, Sugiyama, Timpl, Timpl, Timpl, Tsen, Tsen, Tsim, Wallace, Wallace, Weber, Worton, Yurchenco, Yurchenco   +73 more
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Systematic review of mitochondrial dysfunction and oxidative stress in aging: A focus on neuromuscular junctions

Neural Regeneration Research
Mitochondrial dysfunction and oxidative stress are widely regarded as primary drivers of aging and are associated with several neurodegenerative diseases.
Senlin Chai, Ning Zhang, Can Cui, Zhengyuan Bao, Qianjin Wang, Wujian Lin, Ronald Man Yeung Wong, Sheung Wai Law, Rebecca Schönmehl, Christoph Brochhausen, Wing Hoi Cheung   +10 more
doaj   +1 more source