Results 51 to 60 of about 49,589 (307)

The Use of Noninvasive Mechanical Ventilation in Myasthenic Crisis

Türk Yoğun Bakim Derneği Dergisi, 2012
Myasthenia gravis is an autoimmune disease of the nicotinic acetylcholin receptors at the postsynaptic membrane of the neuromuscular junction. Myasthenic crisis, defined as respiratory failure requiring mechanical ventilation is a common life-threatening
Mustafa Said Aydoğan, M. Ali Erdoğan, Aytaç Yücel, Ülkü Özgül, Hüseyin Konur, Türkan Toğal, Mahmut Durmuş   +6 more
doaj   +1 more source

3D Compartmentalised Human Pluripotent Stem Cell–derived Neuromuscular Co-cultures

Bio-Protocol, 2023
Human neuromuscular diseases represent a diverse group of disorders with unmet clinical need, ranging from muscular dystrophies, such as Duchenne muscular dystrophy (DMD), to neurodegenerative disorders, such as amyotrophic lateral sclerosis (ALS).
Peter Harley, Amaia Paredes-Redondo, Gianluca Grenci, Virgile Viasnoff, Yung- Lin, Ivo Lieberam   +5 more
doaj   +1 more source

Neuromuscular magnetic stimulation counteracts muscle decline in ALS patients: results of a randomized, double-blind, controlled study [PDF]

, 2019
The aim of the study was to verify whether neuromuscular magnetic stimulation (NMMS) improves muscle function in spinal-onset amyotrophic lateral sclerosis (ALS) patients.
Cambieri, Chiara, Ceccanti, Marco, Cerbelli, Bruna, Cifelli, Pierangelo, Cristina Gori, Maria, Dobrowolny, Gabriella, Frasca, Vittorio, Giordano, Carla, Inghilleri, Maurizio, Lepore, Elisa, Musaro', Antonio, Onesti, Emanuela, Palma, Eleonora, Pisano, Annalinda, Roseti, Cristina, Ruffolo, Gabriele   +15 more
core   +1 more source

Muscle weakness and neuromuscular junctions in aging and disease [PDF]

Geriatrics & Gerontology International, 2010
A critical issue in today's super‐aging society is the need to reduce the burden of family care while continuing to make our medical institutions supportive. A rapidly emerging, major health concern is the debilitating effect of muscle weakness and atrophy from aging, termed sarcopenia; however, the molecular basis of this condition is not well ...
Kazuhiro, Shigemoto, Sachiho, Kubo, Syuuichi, Mori, Shigeru, Yamada, Takuyu, Akiyoshi, Tsuyoshi, Miyazaki   +5 more
openaire   +2 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Congenital diseases of feline muscle and neuromuscular junction

Journal of Feline Medicine and Surgery, 2004
Although muscle diseases occur relatively rarely in cats, a number of congenital feline myopathies have been described over the last 20 years and are reviewed in this paper. Some of them have been reported exclusively in specific breeds, including the hypokalaemic myopathy of Burmese cats, type IV glycogen storage disease in Norwegian Forest cats, or ...
Frédéric, Gaschen, André, Jaggy, Boyd, Jones   +2 more
openaire   +2 more sources

Peripheral nerve and neuromuscular junction pathology in Pompe disease [PDF]

Human Molecular Genetics, 2014
Pompe disease is a systemic metabolic disorder characterized by lack of acid-alpha glucosidase (GAA) resulting in ubiquitous lysosomal glycogen accumulation. Respiratory and ambulatory dysfunction are prominent features in patients with Pompe yet the mechanism defining the development of muscle weakness is currently unclear. Transgenic animal models of
Darin J, Falk, Adrian Gary, Todd, Sooyeon, Lee, Meghan S, Soustek, Mai K, ElMallah, David D, Fuller, Lucia, Notterpek, Barry J, Byrne   +7 more
openaire   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

miR126-5p Downregulation Facilitates Axon Degeneration and NMJ Disruption via a Non-Cell-Autonomous Mechanism in ALS. [PDF]

, 2018
Axon degeneration and disruption of neuromuscular junctions (NMJs) are key events in amyotrophic lateral sclerosis (ALS) pathology. Although the disease\u27s etiology is not fully understood, it is thought to involve a non-cell-autonomous mechanism and ...
Behar, Oded, Bonnie, Avichai, Gradus, Tal, Inbar, Shani, Ionescu, Ariel, Maimon, Roy, Perlson, Eran, Sweetat, Sahar, Trotti, Davide, Wald-Altman, Shane, Weil, Miguel   +10 more
core   +2 more sources

Neuromuscular junction dysfunction in Lafora disease

Disease Models & Mechanisms
ABSTRACT Lafora disease (LD), a fatal neurodegenerative disorder, is caused by mutations in the EPM2A gene encoding laforin phosphatase or NHLRC1 gene encoding malin ubiquitin ligase. LD symptoms include epileptic seizures, ataxia, dementia and cognitive decline.
Monica Shukla, Deepti Chugh, Subramaniam Ganesh   +2 more
openaire   +3 more sources