Results 71 to 80 of about 49,589 (307)

Generation of functional posterior spinal motor neurons from hPSCs-derived human spinal cord neural progenitor cells

open access: yesCell Regeneration, 2023
Spinal motor neurons deficiency results in a series of devastating disorders such as amyotrophic lateral sclerosis (ALS), spinal muscular atrophy (SMA) and spinal cord injury (SCI).
He Jax Xu   +11 more
doaj   +1 more source

Clinical Practice Guideline for Evaluation and Management of Peripheral Nervous System Manifestations in Sjögren's Disease

open access: yesArthritis Care &Research, EarlyView.
Objective Sjögren's disease is an autoimmune disorder that can impact multiple organ systems, including the peripheral nervous system (PNS). PNS manifestations, which can exist concurrently, include mononeuropathies, polyneuropathies, and autonomic nervous system neuropathies.
Anahita Deboo   +88 more
wiley   +1 more source

Depressive Syndromes in Autoimmune Disorders of the Nervous System: Prevalence, Etiology, and Influence

open access: yesFrontiers in Psychiatry, 2018
Autoimmune diseases of the nervous system (ADNS) consist of a group of severely disabling disorders characterized by abnormal immune attack against protein components of the nervous system.
Yanjun Liu, Xiangqi Tang
doaj   +1 more source

Relationship between hearing function and myasthenia gravis: a contemporary review [PDF]

open access: yes, 2016
There is increasing evidence of a connection between hearing function and myasthenia gravis (MG). Studies of the pathophysiological basis of this relationship suggest that acetylcholine receptors (AChRs) on outer hair cells (OHCs) play a central role. In
ALTISSIMI, Giancarlo   +5 more
core   +1 more source

Practical Anatomy of the Neuromuscular Junction in Health and Disease [PDF]

open access: yesNeurologic Clinics, 2018
Neuromuscular junctions (NMJs) form between nerve terminals of spinal cord motor neurons and skeletal muscles, and perisynaptic Schwann cells and kranocytes cap NMJs. One muscle fiber has one NMJ, which is innervated by one motor nerve terminal.
Hiroshi, Nishimune, Kazuhiro, Shigemoto
openaire   +2 more sources

Unlocking the Complexity of Neuromuscular Diseases: Insights from Human Pluripotent Stem Cell-Derived Neuromuscular Junctions

open access: yesInternational Journal of Molecular Sciences, 2023
Over the past 20 years, the use of pluripotent stem cells to mimic the complexities of the human neuromuscular junction has received much attention. Deciphering the key mechanisms underlying the establishment and maturation of this complex synapse has been driven by the dual goals of addressing developmental questions and gaining insight into ...
Gazzola, Morgan, Martinat, Cécile
openaire   +2 more sources

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

open access: yesAdvanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz   +3 more
wiley   +1 more source

Establishment and application of clinical biobanks in treating neuromuscular diseases

open access: yesChinese Journal of Contemporary Neurology and Neurosurgery, 2016
Neuromuscular diseases refer to a group of diseases mainly involving peripheral nerve, neuromuscular junction (NMJ) and muscle. Except for the traditional clinical diagnosis, such as serological tests, neuroelectrophysiological study and pathological ...
Ya-wen ZHAO, Qiu-rong ZHANG, Wei ZHANG
doaj  

Development of a high-throughput tailored imaging method in zebrafish to understand and treat neuromuscular diseases

open access: yesFrontiers in Molecular Neuroscience, 2022
The zebrafish (Danio rerio) is a vertebrate species offering multitude of advantages for the study of conserved biological systems in human and has considerably enriched our knowledge in developmental biology and physiology.
Léa Lescouzères   +2 more
doaj   +1 more source

Caenorhabditis elegans muscle Cys-loop receptors as novel targets of terpenoids with potential anthelmintic activity [PDF]

open access: yes, 2019
The anthelmintic treatment of nematode infections remains the pillar of worm control in both human and veterinary medicine. Since control is threatened by the appearance of drug resistant nematodes, there is a need to develop novel compounds, among which
Bouzat, Cecilia Beatriz   +2 more
core   +1 more source

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