Results 91 to 100 of about 49,589 (307)

Emerging Roles of Dysregulated MicroRNAs in Myasthenia Gravis

Frontiers in Neuroscience, 2020
Myasthenia gravis (MG) is a rare acquired autoimmune neuromuscular disease. Autoantibodies, cellular immunity, complement, and cytokines are involved in the pathogenesis of MG. It is characterized by the dysfunction of neuromuscular junction transmission
Lin Wang, Lijuan Zhang
doaj   +1 more source

Strength Training Prior to Endurance Exercise: Impact on the Neuromuscular System, Endurance Performance and Cardiorespiratory Responses [PDF]

, 2014
This study aimed to investigate the acute effects of two strength-training protocols on the neuromuscular and cardiorespiratory responses during endurance exercise. Thirteen young males (23.2 ± 1.6 years old) participated in this study.
Bottaro, Martim, Cadore, Eduardo Lusa, Conceição, Matheus, Dornelles Schneider, Cláudia, Ferrari, Rodrigo, González-Izal, Miriam, Izquierdo, Mikel, Kruel, Luiz Fernando Martins, Liedtke, Giane Veiga, Pinto, Ronei Silveira, Reistenbach Goltz, Fernanda, Wilhelm, Eurico N.   +11 more
core   +2 more sources

Vision‐Augmented Wearable Interfaces: Bioinspired Approaches for Realistic AI‐Human‐Machine Interaction

Advanced Materials Technologies, EarlyView.
This review presents recent progress in vision‐augmented wearable interfaces that combine artificial vision, soft wearable sensors, and exoskeletal robots. Inspired by biological visual systems, these technologies enable multimodal perception and intelligent human–machine interaction.
Jihun Lee, Gwuidong Ryu, Kisoo Kim, Feng Xu, Won Gu Lee   +4 more
wiley   +1 more source

The MX-Helix of Muscle nAChR Subunits Regulates Receptor Assembly and Surface Trafficking. [PDF]

, 2020
Nicotinic acetylcholine receptors (AChRs) are pentameric channels that mediate fast transmission at the neuromuscular junction (NMJ) and defects in receptor expression underlie neuromuscular disorders such as myasthenia gravis and congenital myasthenic ...
Borges, Lucia Soares, Ferns, Michael, Rudell, Jolene Chang, Yarov-Yarovoy, Vladimir   +3 more
core  

Temporal and Cell‐Specific Regulation of Synaptic Homeostasis by the Chromatin Remodeler Chd1

Advanced Science, EarlyView.
Chd1, the Drosophila homologue of mammalian CHD2 ‐ a gene linked to autism, epilepsy, and intellectual disability, is required for synaptic homeostatic plasticity. Chd1 in glia is necessary for the rapid induction of synaptic homeostasis, whereas Chd1 in motoneurons, muscle, and glia is critical for long‐term maintenance.
Danielle T. Morency, Tao Cui, Yimei Cai, Chloe Lok, Rachel E. Nokku, Ruoxian Huang, Grace L. Chu, Yumeng Xie, Saleem W. Abu‐Tayeh, Kaikai He, Chengjie Qiu, Junyi Wang, Paxton M. Paganelli, Ting Wang, Gabrielle Williams, Sreejith Nair, Huadong Pei, Dion K. Dickman, Stefano Vicini, Tingting Wang   +19 more
wiley   +1 more source

A Novel Acetylcholine Nanosensor for Single Vesicle Storage and Sub‐Quantal Exocytosis in Living Neurons and Organoids

Angewandte Chemie, EarlyView.
Schematic representation of M@E@CF nanosensors for detecting vesicular storage and release in cholinergic neurons and brain organoids. (A) Nano‐tip microelectrodes modification via molds fabricated through 3D printing. (B) the reaction mechanism for acetylcholine detection at the electrode interface.
Wanying Zhu, Yufan Zhang, Hanwen Yu, Da Wang, Xinyue Zhang, Xiaowen Du, Shanshan Wu, Bingzhi Li, Yizhou Zhang, Hongliang Xin, Xing Guo, Yan Liu   +11 more
wiley   +2 more sources

Increased acetylation of microtubules rescues human tau-induced microtubule defects and neuromuscular junction abnormalities in Drosophila

Disease Models & Mechanisms, 2017
Tau normally associates with and stabilizes microtubules (MTs), but is hyperphosphorylated and aggregated into neurofibrillary tangles in Alzheimer's disease and related neurodegenerative diseases, which are collectively known as tauopathies.
Chuan-Xi Mao, Xue Wen, Shan Jin, Yong Q. Zhang   +3 more
doaj   +1 more source

A Splicing Mutation in the Novel Mitochondrial Protein DNAJC11 Causes Motor Neuron Pathology Associated with Cristae Disorganization, and Lymphoid Abnormalities in Mice [PDF]

, 2014
Mitochondrial structure and function is emerging as a major contributor to neuromuscular disease, highlighting the need for the complete elucidation of the underlying molecular and pathophysiological mechanisms. Following a forward genetics approach with
Douni, E, Eliopoulos, E, Fasseas, C, Ioakeimidis, F, Kollias, G, Kozjak-Pavlovic, V, Makrinou, E, Ott, C, Rinotas, V, Violitzi, F   +9 more
core   +1 more source

Algorithm for jitter measurement in neuromuscular junction disease

Journal of Electromyography and Kinesiology
The objective of this work was to extend the evaluation of a recently proposed method for estimating neuromuscular jitter within motor unit potential (MUP) trains extracted from muscles suffering neuromuscular junction disease. The method detects, within the MUP duration, “single-fiber” intervals that have likely been produced by single muscle fibers ...
Armando Malanda, Daniel Stashuk, César Valle, Javier Rodríguez-Falces, Javier Navallas, Mamede de Carvalho, José Castro, Oscar Garnés-Camarena   +7 more
openaire   +2 more sources

The Role of Ionic Liquids at the Biological Interfaces in Bioelectronics

Advanced Science, EarlyView.
Ionic liquids (ILs) are highlighted as key artificial ionic materials that bridge biological ion‐based signaling and electronic devices. By understanding their composition, structure, function relationships, and mechanisms, ILs can advance from high performance electrolyte to core materials enabling integrated, multifunctional bioelectronics for ...
Yeong‐sinn Ye, Young Jin Jo, Ji Yeon Oh, Ju Yeon Jeong, Lili Guo, Tae‐il Kim   +5 more
wiley   +1 more source