Evaluating the peripheral nervous system pathology of Alzheimer's disease utilizing a functional human NMJ microphysiological system. [PDF]
Alzheimers DementKargazhanov A +11 more
europepmc +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney +4 more
wiley +1 more source
The chaperonin TRiC component Cct3 is required for axonal transport, myelination, and neuromuscular junction refinement. [PDF]
Cell Death DisZhang X +7 more
europepmc +1 more source
Intramuscular pathways of maladaptation in overtraining syndrome
The Journal of Physiology, EarlyView.Abstract figure legend The transition from adaptive overreaching to maladaptive overtraining and mechanisms through which excessive training load can lead to performance decline. Four interconnected pathophysiological domains are highlighted: neural fatigue, involving both central and peripheral components such as altered sensory feedback and reflex ...
Emily Shorter +4 more
wiley +1 more source
New Insights into Neuromuscular Junction Biology: Evidence from Human and Animal Research. [PDF]
Int J Mol SciLiang Z, Chen X, Nourbakhsh M.
europepmc +1 more source
Mitochondrial haplotype and sex modulate responses to endurance exercise training
The Journal of Physiology, EarlyView.Abstract figure legend Using OKC‐HETB/W rats we demonstrate that mitochondrial haplotype influences training responses of endurance exercise. Overall OKC‐HETW rats showed greater responses than OKC‐HETB in exercise tolerance, mitochondrial bioenergetics, mitochondrial DNA (mtDNA) mutation frequencies and motor co‐ordination.
Bumsoo Ahn +8 more
wiley +1 more source
Neuromuscular fatigability with repeated exercise in hypoxia: From single‐joint paradigms to sprints
The Journal of Physiology, EarlyView.Abstract figure legend Acute hypobaric or normobaric hypoxic exposure accelerates neuromuscular fatigability during repeated exercise. Indices of peripheral and central fatigue are not different at exhaustion in mild, moderate and severe hypoxia compared with normoxia, but task failure occurs earlier.
Luca Ruggiero +5 more
wiley +1 more source
Evaluation of Muscle Oxygenation by Functional Near-Infrared Spectroscopy in Patients with Myasthenia Gravis During Rest and Exercise. [PDF]
Noro Psikiyatr ArsSemiz EC +4 more
europepmc +1 more source
From Earth to orbit: How to preserve muscle health in space and bed rest
Experimental Physiology, EarlyView.
Antonios Matsakas, Colleen Deane
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The Journal of Physiology, EarlyView.Abstract figure legend Exacerbated ATP signalling in the carotid body (CB) of spontaneously hypertensive rats (SHRs) arises from expansion of the chemosensory glomus cell compartment and reduced extracellular ATP metabolism, leading to increased purinergic drive.
Igor S. A. Felippe +11 more
wiley +1 more source