Results 111 to 120 of about 32,201 (250)
The review analyzed 87 studies from 20 countries on environmental risk factors for MS. EBV infection increased MS risk, while breastfeeding showed limited protection. Adverse social experiences, active smoking, and obesity in childhood/adolescence raised risk, whereas normal BMI was protective.
Bruno Kusznir Vitturi +8 more
wiley +1 more source
Study of the cytological features of bone marrow mesenchymal stem cells from patients with neuromyelitis optica. [PDF]
Neuromyelitis optica (NMO) is a refractory autoimmune inflammatory disease of the central nervous system without an effective cure. Autologous bone marrow‑derived mesenchymal stem cells (BM‑MSCs) are considered to be promising therapeutic agents for this
Chang, Guoqiang +6 more
core +1 more source
Hypersensitivity Responses in the Central Nervous System [PDF]
Immune-mediated tissue damage or hypersensitivity can be mediated by autospecific IgG antibodies. Pathology results from activation of complement, and antibody-dependent cellular cytotoxicity (ADCC), mediated by inflammatory effector leukocytes include ...
Carsten Tue Berg +5 more
core +4 more sources
The membrane attack complex (MAC) is formed by the stepwise assembly of five proteins: C5b, C6, C7, C8 and C9. MAC plays a key role in driving inflammation in numerous diseases. This study compares the inhibitory mechanisms of MAC assembly by soluble CD59 (sCD59), a disulphide‐locked C9 mutant (C9lock) and horse C9 (HoC9).
Rebekah S. Cooke +5 more
wiley +1 more source
The diagnostic and prognostic value of neurofilament heavy chain levels in immune-mediated optic neuropathies [PDF]
Background. Loss of visual function differs between immune-mediated optic neuropathies and is related to axonal loss in the optic nerve. This study investigated the diagnostic and prognostic value of a biomarker for neurodegeneration, the neurofilament ...
Petzold, A, Plant, GT
core +4 more sources
Cerebrospinal fluid aquaporin-4-immunoglobulin G disrupts blood brain barrier [PDF]
To clarify the significance of immunoglobulin G autoantibody specific for the astrocyte water channel aquaporin-4 in cerebrospinal fluid, aquaporin-4-immunoglobulin G from a neuromyelitis optica patient was administered intrathecally to naïve mice, and ...
Asgari, Nasrin +4 more
core +2 more sources
Aquaporin modulators: a patent review (2010-2015) [PDF]
Introduction: Since the discovery of aquaporin-1 (AQP1) as a water channel, more than 2,000 articles, reviews and chapters have been published.
Casini, Angela, Soveral, Graça
core +1 more source
MOG encephalomyelitis: international recommendations on diagnosis and antibody testing [PDF]
Over the past few years, new-generation cell-based assays have demonstrated a robust association of autoantibodies to full-length human myelin oligodendrocyte glycoprotein (MOG-IgG) with (mostly recurrent) optic neuritis, myelitis and brainstem ...
Aktas, O. +18 more
core +9 more sources
Systemic lupus erythematosus is an autoimmune disease. Neuromyelitis optica (Devic’s disease) is an inflammatory disorder belonging to the central nervous system.
Asal Azami, Mohammadhassan Jokar
doaj

