Results 81 to 90 of about 26,034 (198)

Hypersensitivity Responses in the Central Nervous System [PDF]

, 2015
Immune-mediated tissue damage or hypersensitivity can be mediated by autospecific IgG antibodies. Pathology results from activation of complement, and antibody-dependent cellular cytotoxicity (ADCC), mediated by inflammatory effector leukocytes include ...
Carsten Tue Berg, Marlene Thorsen Mørch, Nasrin eAsgari, Nasrin eAsgari, Reza eKhorooshi, Trevor eOwens   +5 more
core   +4 more sources

A two‐sample Mendelian randomization study and mediation analysis exploring the link between cathepsins and epilepsy

Epilepsia Open, EarlyView.
Abstract Objective This study aims to investigate the causal relationship between cathepsins and epilepsy, using Mendelian randomization (MR) and mediation analysis. Methods Publicly accessible summary statistics on epilepsy were obtained from FinnGen and the International League Against Epilepsy Consortium.
Huaiyu Sun, Di Ma, Wuqiong Zhang, Shuai Hou, Zhiqing Chen, Xuewei Li, Hongmei Meng, Daguang Zhang   +7 more
wiley   +1 more source

Study of the cytological features of bone marrow mesenchymal stem cells from patients with neuromyelitis optica. [PDF]

, 2019
Neuromyelitis optica (NMO) is a refractory autoimmune inflammatory disease of the central nervous system without an effective cure. Autologous bone marrow‑derived mesenchymal stem cells (BM‑MSCs) are considered to be promising therapeutic agents for this
Chang, Guoqiang, Ma, Li, Shi, Fu-Dong, Yan, Yaping, Yang, Chunsheng, Yang, Yang, Zhang, Guang-Xian   +6 more
core   +1 more source

Clinical course, therapeutic responses and outcomes in relapsing MOG antibody-associated demyelination. [PDF]

, 2018
OBJECTIVE: We characterised the clinical course, treatment and outcomes in 59 patients with relapsing myelin oligodendrocyte glycoprotein (MOG) antibody-associated demyelination.
Australasian and New Zealand MOG Study Group Andrews, P, Barnett, Mh, Barton, J, Brilot, F, Broadley, S, Burrow, J, Butzkueven, H, Cairns, A, Calvert, S, Caruana, P, Chelakkadan, S, Clark, D, Dale, Rc, Fraser, C, Freeman, J, Fung, Vsc, Gill, D, Grattan-Smith, P, Gupta, S, Hardy, T, Henderson, Apd, Kothur, K, Lechner-Scott, J, Ling, S, Lopez, J, Malone, S, Marriott, M, Merheb, V, Mohammad, S, Nguyen, Tk, Nosadini, M, O'grady, G, Orr, C, Ouvrier, R, Parratt, J, Patrick, E, Pilli, D, Ramanathan, S, Reddel, Sw, Riminton, D, Riney, K, Rodriguez-Casero, V, Ryan, M, Scheffer, I, Shah, U, Shuey, N, Spooner, C, Subramanian, G, Tantsis, E, Tea, F, Thomas, T, Thompson, J, Troedson, C, Vucic, S, Ware, T, Webster, R, White, Ob, Yiannikas, C, Yiu, E, Zou, A.   +59 more
core   +1 more source

Movement Disorders in Neuromyelitis Optica Spectrum Disorder: A Systematic Review

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Several movement disorders (MD) have been reported to occur in neuromyelitis optica spectrum disorder (NMOSD). No extensive review has addressed the whole spectrum of MD in NMOSD. Objective This article aims to review MD in NMOSD, describing its prevalence and features.
Luciana A.F. Bringel, Pedro L.G.S.B. Lima, Pedro V.F. Rodrigues, Francisco L.H.B. Cavalcante, Amanda R. Pinheiro, Fabricia M.S. Saraiva, Cynthia P. Rodrigues, Paulo V.S. Gonçalves, Leonardo J.R.A. Melo, Antônio E. Camelo‐Filho, Avelino M. Dutra‐Junior, Samuel R.O. Veras, Fernanda M.M. Carvalho, Flávia P.S. Rolim, Gabriela J. Martins, José A.C. D'Almeida, Pedro Braga‐Neto, Milena S. Pitombeira, Paulo R. Nobrega   +18 more
wiley   +1 more source

Clinical, outcome and aetiological chacteristics of inflammatory optic neuropathies. A series of Algerian patients. [PDF]

Batna Journal of Medical Sciences
Introduction. Inflammatory optic neuropathies (ION) are frequent neuroophthalmological emergencies. They often pose an etiological problem. Objectives. To study the clinical, radiological, etiological and evolutionary particularities of ION in Algerian
Mohamed Islam KEDIHA, Dalila MOUALEK, Farida MOSTEFAOUI, Lamia ALI PACHA   +3 more
doaj   +1 more source

Functional characterization of reappearing B cells after anti-CD20 treatment of CNS autoimmune disease. [PDF]

, 2018
The anti-CD20 antibody ocrelizumab, approved for treatment of multiple sclerosis, leads to rapid elimination of B cells from the blood. The extent of B cell depletion and kinetics of their recovery in different immune compartments is largely unknown ...
Bernard, Claude CA, Brück, Wolfgang, Feldmann, Linda, Häusler, Darius, Häusser-Kinzel, Silke, Lehmann-Horn, Klaus, Lepennetier, Gildas, Torke, Sebastian, Weber, Martin S, Zamvil, Scott S   +9 more
core   +1 more source

The Second Hit Hypothesis in Animal and Human Dystonia: The Role of Peripheral Nerve Trauma and Spinal Cord Injury

Movement Disorders, EarlyView.
The “second‐hit” hypothesis proposes that both a genetic predisposition and an environmental insult—such as peripheral nerve trauma or spinal cord injury—are required for dystonia development. This review explores how neuroinflammation and maladaptive plasticity, triggered by nerve and spinal cord injury, contribute to dystonia pathogenesis.
Lisa Harder‐Rauschenberger, Chi Wang Ip   +1 more
wiley   +1 more source

Experimental mouse model of optic neuritis with inflammatory demyelination produced by passive transfer of neuromyelitis optica-immunoglobulin G. [PDF]

, 2014
Background Although optic neuritis (ON) is a defining feature of neuromyelitis optica (NMO), appropriate animal models of NMO ON are lacking. Most NMO patients are seropositive for immunoglobulin G autoantibodies (NMO-IgG) against the astrocyte water ...
Asavapanumas, N, Bennett, JL, Levin, MH, Papadopoulos, MC, Ratelade, J, Verkman, Alan, Verkman, AS   +6 more
core   +2 more sources

Mercy Consent and Contained Resistance: Grievance Systems in Chinese Food‐Delivery Platforms

New Technology, Work and Employment, EarlyView.
ABSTRACT Based on a multi‐methods qualitative study, this article investigates how in‐platform grievance systems operate in the Chinese food‐delivery platform work. Drawing on labour process theory, we examine the role of in‐platform grievance systems in shaping the dynamic interplay between control, consent, and resistance. Our findings reveal that in‐
Ziheng Liu, Wei Wei
wiley   +1 more source