Results 11 to 20 of about 257,577 (143)
Nature Communications, 2022 Here, authors show that Smad3 acetylation via HDAC6 inhibition reverses Duchenne muscular dystrophy-like symptoms in the mdx mouse model, suggesting a potential therapeutic target for the disorder.
Alexis Osseni +10 more
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Converging Mechanisms of p53 Activation Drive Motor Neuron Degeneration in Spinal Muscular Atrophy
Cell Reports, 2017 The hallmark of spinal muscular atrophy (SMA), an inherited disease caused by ubiquitous deficiency in the SMN protein, is the selective degeneration of subsets of spinal motor neurons.
Christian M. Simon +10 more
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Nature Communications, 2023 Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive motor neuron loss, with additional pathophysiological involvement of non-neuronal cells such as microglia.
Björn F. Vahsen +18 more
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Molecular Brain, 2017 The tree shrew, as a primate-like animal model, has been used for studying high brain functions such as social emotion and spatial learning memory. However, little is known about the excitatory synaptic transmission in cortical brain areas of the tree ...
Xu-Hui Li +5 more
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Microvascular decompression for hemifacial spasm: a review of twenty-one operated cases
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 2020 Background Microvascular decompression of facial nerve provides definitive and long-term cure for hemifacial spasm. We review our experience of treating hemifacial spasm by microvascular decompression.
Amey P. Patankar
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Molecular Brain, 2020 An amendment to this paper has been published and can be accessed via the original article.
Kohei Koga +10 more
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Stochastic mechanism for improving selectivity of olfactory projection neurons [PDF]
Neurophysiology (2019) 51: 152-159, 2019 A mechanism is proposed for increasing selectivity of olfactory bulb projection neurons as compared to the olfactory receptor neurons, which could operate under low odor concentration, when the lateral inhibition mechanism becomes inefficient. The mechanism proposed is based on the threshold-type reaction to stimuli a projection neuron receives from ...
arxiv +1 more source
Human iPSC co-culture model to investigate the interaction between microglia and motor neurons
Scientific Reports, 2022 Motor neuron diseases such as amyotrophic lateral sclerosis are primarily characterized by motor neuron degeneration with additional involvement of non-neuronal cells, in particular, microglia.
Björn F. Vahsen +13 more
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Molecular Brain, 2021 Parkinson’s disease (PD) is a multi-system neurodegenerative disorder. Patients with PD often suffer chronic pain. In the present study, we investigated motor, sensory and emotional changes in three different PD mice models.
Zhaoxiang Zhou +13 more
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Two distinct desynchronization processes caused by lesions in globally coupled neurons [PDF]
Papers in Physics 7, 070002 (2015), 2015 To accomplish a task, the brain works like a synchronized neuronal network where all the involved neurons work together. When a lesion spreads in the brain, depending on its evolution, it can reach a significant portion of relevant area. As a consequence, a phase transition might occur: the neurons desynchronize and cannot perform a certain task ...
arxiv +1 more source