Results 31 to 40 of about 1,037,185 (302)

Pink1 protects cortical neurons from thapsigargin-induced oxidative stress and neuronal apoptosis

Bioscience Reports, 2015
Apoptosis mediates the precise and programmed natural death of neurons and is a physiologically important process in neurogenesis during maturation of the central nervous system.
Lin Li, Guo‑ku Hu
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Excitotoxins in Neuronal Apoptosis and Necrosis [PDF]

Journal of Cerebral Blood Flow & Metabolism, 1999
Neuronal loss is common to many neurodegenerative diseases. Although necrosis is a common histopathologic feature observed in neuropathologic conditions, evidence is increasing that apoptosis can significantly contribute to neuronal demise. The prevalence of either type of cell death, apoptosis or necrosis, and the relevance for the progression of ...
P, Nicotera, S A, Lipton
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p25/Cdk5-mediated retinoblastoma phosphorylation is an early event in neuronal cell death [PDF]

, 2005
In large models of neuronal cell death, there is a tight correlation between Cdk5 deregulation and cell-cycle dysfunction. However, pathways that link Cdk5 to the cell cycle during neuronal death are still unclear.
Sambo, Anne-Véronique, Philippe Bertrand, Bégard, Séverine, Luc Buée, André Delacourte, Séverine Bégard, Bertrand, Philippe, Hamdane, Malika, Katharina Schindowski, Bretteville, Alexis, Anne-Véronique Sambo, Schindowski, Katharina, Delacourte, André, Buée, Luc, Malika Hamdane, Alexis Bretteville   +15 more
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Apoptosis in oligodendrocytes is associated with axonal degeneration in P301L tau mice

Neurobiology of Disease, 2004
Transgenic mice overexpressing human tau with the P301L mutation develop neurofibrillary tangles, extensive gliosis, adult-onset motor abnormalities, and neuronal loss in affected brain regions.
Cindy Zehr, Jada Lewis, Eileen McGowan, Julia Crook, Wen-Lang Lin, Kate Godwin, Joshua Knight, Dennis W Dickson, Mike Hutton   +8 more
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NGR1 attenuates neuronal apoptosis after TBI.

, 2023
(A-B) Nissl staining to detect cortical neuronal apoptosis in each group and quantitative analysis of Nissl positive cells. Data are expressed as mean ± SD, n = 6 for each group.
Xiaoxian Pei (10653371), Xiaowei Li (620087), Xiangdong Du (2391289), Dan Liu (108669), Yajuan Wu (1736224), Ling Zhang (18071), Ying Cao (170160)   +6 more
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Activation of Sirtuin 1 Attenuates High Glucose-Induced Neuronal Apoptosis by Deacetylating p53

Frontiers in Endocrinology, 2018
Diabetes mellitus (DM) has been proven to be a key risk factor for cognitive impairment. Previous studies have implicated hippocampal neuronal apoptosis in diabetes-related cognitive impairment. However, the underlying mechanism remains unknown.
Xiajie Shi, Xiajie Shi, Linhua Pi, Shanlei Zhou, Xin Li, Fangyuan Min, Shan Wang, Zhenqi Liu, Jing Wu   +8 more
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Albumin alleviated esketamine-induced neuronal apoptosis of rat retina through downregulation of Zn2+-dependent matrix metalloproteinase 9 during the early development

BMC Neuroscience, 2022
Aims Esketamine upregulates Zn2+-dependent matrix metalloproteinase 9 (MMP9) and increases the neuronal apoptosis in retinal ganglion cell layer during the early development.
Kan Zhang, Ruijing Ma, Luping Feng, Peiwen Liu, Shuang Cai, Chaoyang Tong, Jijian Zheng   +6 more
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Effects of lncRNA HOXA11-AS on Sevoflurane-Induced Neuronal Apoptosis and Inflammatory Responses by Regulating miR-98-5p/EphA4

Mediators of Inflammation, 2023
Objective. To explore the molecular mechanism of sevoflurane-induced neurotoxicity and to determine whether lncRNA HOXA11-AS affects sevoflurane-induced neuronal apoptosis and inflammation by regulating miR-98-5p/EphA4. Methods.
Li Zhao, Zhonghui Wang, Haitao Chen, Yaxi Du, Weihao Ma, Qunfen Tao, Xiang Ma, Zeming Wu, Jing Peng   +8 more
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Sevoflurane-Induced miR-211-5p Promotes Neuronal Apoptosis by Inhibiting Efemp2

ASN Neuro, 2021
Sevoflurane exposure can result in serious neurological side effects including neuronal apoptosis and cognitive impairment. Although the microRNA miR-211-5p is profoundly upregulated following sevoflurane exposure in neonatal rodent models, the impact of
Yousu Shen, Tao Zhou, Xiaobing Liu, Yanlong Liu, Yaqi Li, Dewu Zeng, Wensheng Zhong, Mingsheng Zhang   +7 more
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Acetylcholinesterase promotes apoptosis in insect neurons [PDF]

Apoptosis, 2020
AbstractApoptosis plays a major role in development, tissue renewal and the progression of degenerative diseases. Studies on various types of mammalian cells reported a pro-apoptotic function of acetylcholinesterase (AChE), particularly in the formation of the apoptosome and the degradation of nuclear DNA.
Knorr, Debbra Y., Georges, Nadine S., Pauls, Stephanie, Heinrich, Ralf, Knorr, Debbra Y.; Department of Cellular Neurobiology, Johann-Friedrich-Blumenbach-Institute for Zoology and Anthropology, Georg-August-University Göttingen, Göttingen, Germany, Georges, Nadine S.; Department of Cellular Neurobiology, Johann-Friedrich-Blumenbach-Institute for Zoology and Anthropology, Georg-August-University Göttingen, Göttingen, Germany, Pauls, Stephanie; Department of Cellular Neurobiology, Johann-Friedrich-Blumenbach-Institute for Zoology and Anthropology, Georg-August-University Göttingen, Göttingen, Germany, Heinrich, Ralf; Department of Cellular Neurobiology, Johann-Friedrich-Blumenbach-Institute for Zoology and Anthropology, Georg-August-University Göttingen, Göttingen, Germany   +7 more
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