Results 11 to 20 of about 1,037,185 (302)

Measurements of Neuronal Apoptosis

, 2011
Apoptosis is a natural process occurring during the development of central nervous system resulting in the elimination of neurons that may have formed faulty synapses. Apoptosis can also be triggered by deprivation of growth factors or by exposure to a variety of endogenous or exogenous compounds.
GIORDANO G., COSTA, Lucio Guido
openaire   +5 more sources

Role of Mitochondria in Neuronal Apoptosis

Developmental Neuroscience, 2000
Apoptosis is a controlled form of cell death that participates in the demise of neuronal cells during development, neurodegenerative disorders and exposure to neurotoxic agents. In recent years, the mitochondria have emerged as being pivotal in controlling apoptosis.
Gorman, Adrienne M., Ceccatelli, Sandra, Orrenius, Sten   +2 more
openaire   +4 more sources

Staurosporine-Induced Neuronal Apoptosis

Experimental Neurology, 1995
Staurosporine, a nonselective protein kinase inhibitor, has been shown to induce apoptosis in several different nonneuronal cell types. We tested the hypothesis that staurosporine would also induce apoptosis in central neurons. Exposure of murine cortical cell cultures to 30-100 nM staurosporine induced concentration-dependent selective neuronal ...
J Y, Koh, M B, Wie, B J, Gwag, S L, Sensi, L M, Canzoniero, J, Demaro, C, Csernansky, D W, Choi   +7 more
openaire   +3 more sources

Neuroprotective effects of ganoderma lucidum polysaccharides against oxidative stress-induced neuronal apoptosis

Neural Regeneration Research, 2017
Ganoderma lucidum polysaccharides have protective effects against apoptosis in neurons exposed to ischemia/reperfusion injury, but the mechanisms are unclear. The goal of this study was to investigate the underlying mechanisms of the effects of ganoderma
Xin-zhi Sun, Ying Liao, Wei Li, Li-mei Guo   +3 more
doaj   +2 more sources

Role of RB1 in neurodegenerative diseases: inhibition of post-mitotic neuronal apoptosis via Kmt5b

Cell Death Discovery
During the development of the vertebrate nervous system, 50% of the nerve cells undergo apoptosis shortly after formation. This process is important for sculpting tissue during morphogenesis and removing transiently functional cells that are no longer ...
Shuang Zhao, Guiling Mo, Qiang Wang, Jin Xu, Shihui Yu, Zhibin Huang, Wei Liu, Wenqing Zhang   +7 more
doaj   +2 more sources

A Genomic Approach to Investigate Neuronal Apoptosis

Current Alzheimer Research, 2006
Apoptosis has been postulated to play a possible causal role in the onset of Alzheimer's disease due to shortage of trophic supply, deafferentation and excessive production of free radicals. Many experiments in the past have demonstrated the requirement of de novo gene expression during neuronal apoptosis.
Cavallaro Sebastiano, Calissano Pietro
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Pin1 in Neuronal Apoptosis [PDF]

Cell Cycle, 2007
While the role of the prolyl isomerase Pin1 in dividing cells has long been recognized, Pin1's function in postmitotic neurons is poorly understood. We have identified a novel mechanism by which Pin1 mediates activation of the mitochondrial cell death machinery specifically in neurons.
Becker, E, Bonni, A
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Deficiency of the microglial Hv1 proton channel attenuates neuronal pyroptosis and inhibits inflammatory reaction after spinal cord injury

Journal of Neuroinflammation, 2020
Background Spinal cord injury (SCI) causes neurological dysfunction with devastating consequences. SCI pathogenesis is accompanied by inflammasome activation and neuronal damage.
Xuefei Li, Zhiyuan Yu, Weifeng Zong, Peng Chen, Jia Li, Minghuan Wang, Fengfei Ding, Minjie Xie, Wei Wang, Xiang Luo   +9 more
doaj   +1 more source

HIF-1α Mediates TRAIL-Induced Neuronal Apoptosis via Regulating DcR1 Expression Following Traumatic Brain Injury

Frontiers in Cellular Neuroscience, 2020
Background: Neuronal apoptosis involved in secondary injury following traumatic brain injury (TBI) significantly contributes to the poor outcomes of patients with TBI.
Yuanjian Fang, Jianan Lu, Xiaoyu Wang, Haijian Wu, Shuhao Mei, Jingwei Zheng, Shenbin Xu, Cameron Lenahan, Cameron Lenahan, Sheng Chen, Jianmin Zhang, Jianmin Zhang, Jianmin Zhang, Yuan Hong   +13 more
doaj   +1 more source

lncRNA Xist regulates sevoflurane-induced social and emotional impairment by modulating miR-98-5p/EDEM1 signaling axis in neonatal mice

Molecular Therapy: Nucleic Acids, 2021
Long non-coding RNA (lncRNA) X-inactive specific transcript (Xist) is involved in apoptosis and inflammatory injury. This study aimed to assess the role of lncRNA Xist in sevoflurane-induced social and emotional impairment and neuronal apoptosis in ...
Lili Xu, Qi Xu, Shaobing Dai, Cuicui Jiao, Yingying Tang, Jiaqian Xie, Hui Wu, Xinzhong Chen   +7 more
doaj   +1 more source