Results 1 to 10 of about 1,037,185 (302)

Treponema denticola Induces Neuronal Apoptosis by Promoting Amyloid-β Accumulation in Mice

Pathogens, 2022
Background: Neuronal apoptosis is a major contributor to Alzheimer’s disease (AD). Periodontitis is a significant risk factor for AD. The periodontal pathogens Porphyromonas gingivalis and Treponema denticola have been shown to initiate the hallmark ...
Linrui Wu, Xinyi Su, Zhiqun Tang, Lixiang Jian, He Zhu, Xingqun Cheng, Hongkun Wu   +6 more
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Electroacupuncture inhibited neuronal apoptosis through PGAM5/FUNDC1-dependent mitophagy after ischemic stroke [PDF]

Chinese Medicine
Neuronal apoptosis persists throughout ischemic stroke. This leads to massive neuron loss and severely impairs recovery of neurological function. Clinical evidence has confirmed that electroacupuncture (EA) effectively improves neurological function ...
Li Zhou, Yicheng Peng, Mingchao Fu, Mei Zhou, Chengcai Zhang, Xichen Yang, Yongdan Cun, Simei Zhang, Na Chen, Rong Ning, Yaju Jin, Zuhong Wang, Hong Xin, Pengyue Zhang   +13 more
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Downregulation of the deubiquitinating enzyme USP10 correlates with neuronal apoptosis in HTLV-1-associated myelopathy [PDF]

Scientific Reports
Human T-cell leukemia virus type 1–associated myelopathy (HAM) is a chronic neuroinflammatory disease characterized by spinal cord neuronal loss. The mechanisms underlying this degeneration remain unclear.
Shiho Arishima, Masahiko Takahashi, Mika Dozono, Takashi Yoshida, Satoshi Nozuma, Hiroshi Takashima, Masahiro Fujii, Ryuji Kubota   +7 more
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Resveratrol modulates FABP5 to reduce neuronal apoptosis following ischemic stroke [PDF]

Open Life Sciences
Fatty acid–binding proteins (FABPs) influence cellular energy metabolism by regulating fatty acid kinetics. They also play a vital role in neuronal apoptosis following cerebral infarction.
Xing BingFeng, Zhou Xin, Hong Min, Lin WeiHao, Xiang Changqin   +4 more
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Cel-LDH dual-functional nanotherapy simultaneously promotes microglial efferocytosis and alleviates neuronal apoptosis for spinal cord injury recovery [PDF]

Journal of Nanobiotechnology
Traumatic spinal cord injury (SCI) can cause severe central nervous system damage. Efferocytosis, an intrinsic regulatory mechanism through which microglia eliminate apoptotic cells, is suppressed because of the local ischaemic and hypoxic ...
Nuo Chen, Lufeng Yao, Le Zou, Qiuchen Wang, Yaning Li, Junjun Luo, Mengting Zhan, Kailiang Zhou, Jian Xiao, Songlin Tong, Hongyu Zhang, Liangliang Yang, Lu Ge   +12 more
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AVE 0991 attenuates oxidative stress and neuronal apoptosis via Mas/PKA/CREB/UCP-2 pathway after subarachnoid hemorrhage in rats

Redox Biology, 2019
Oxidative stress and neuronal apoptosis have been demonstrated to be key features in early brain injury (EBI) after subarachnoid hemorrhage (SAH). Previous studies have indicated that Mas receptor activation initiates an anti-oxidative and anti-apoptotic
Jun Mo, Budbazar Enkhjargal, Zachary D. Travis, Keren Zhou, Pei Wu, Guangyu Zhang, Qiquan Zhu, Tongyu Zhang, Jianhua Peng, Weilin Xu, Umut Ocak, Yili Chen, Jiping Tang, Jianmin Zhang, John H. Zhang   +14 more
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Neuroprotective effects of zonisamide on cerebral ischemia injury via inhibition of neuronal apoptosis [PDF]

Brazilian Journal of Medical and Biological Research, 2021
It is known that neuronal apoptosis contributes to pathology of cerebral ischemia injury. Zonisamide (ZNS) has shown anti-apoptosis effects in recent studies.
Junna He, Xiangjian Zhang, Weiliang He, Yanzhao Xie, Yanxia Chen, Yang Yang, Rong Chen   +6 more
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Intracellular pathways involved in cell survival are deregulated in mouse and human spinal muscular atrophy motoneurons

Neurobiology of Disease, 2021
Spinal Muscular Atrophy (SMA) is a severe neuromuscular disorder caused by loss of the Survival Motor Neuron 1 gene (SMN1). Due to this depletion of the survival motor neuron (SMN) protein, the disease is characterized by the degeneration of spinal cord ...
Alba Sansa, Sandra de la Fuente, Joan X. Comella, Ana Garcera, Rosa M. Soler   +4 more
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S-adenosylmethionine decarboxylase 1 and its related spermidine synthesis mediate PM2.5 exposure-induced neuronal apoptosis

Ecotoxicology and Environmental Safety, 2021
PM2.5 exposure is considered harmful to central nerve system, while the specific biochemical mechanism underlying is still unrevealed. Neuronal apoptosis is believed the crucial event in pathogenesis of neurodegenerative diseases, but evidence supporting
Xiaozheng Zhu, Yikai Shou, Xintong Ji, Yu Hu, Huanhuan Wang   +4 more
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Ginkgolide B Protects Against Ischemic Stroke via Targeting AMPK/PINK1

Frontiers in Pharmacology, 2022
Introduction: Ginkgolide B (GB), which is an active constituent derived from Ginkgo biloba leaves, has been reported to ameliorate Alzheimer’s disease (AD), ischemic stroke, as well as other neurodegenerative diseases due to its viable immunosuppressive ...
Yile Cao, Lei Yang, Hong Cheng
doaj   +1 more source