Results 21 to 30 of about 1,037,185 (302)

Natural Products in Modulating Methamphetamine-Induced Neuronal Apoptosis

Frontiers in Pharmacology, 2022
Methamphetamine (METH), an amphetamine-type psychostimulant, is highly abused worldwide. Chronic abuse of METH causes neurodegenerative changes in central dopaminergic neurons with numerous neuropsychiatric consequences.
Yiwei Zeng, Yunhui Chen, Su Zhang, Huan Ren, Jialin Xia, Mengnan Liu, Baozhi Shan, Yulan Ren   +7 more
doaj   +1 more source

Apoptosis in Caspase-inhibited Neurons [PDF]

Molecular Medicine, 2001
There is growing evidence of apoptosis in neurodegenerative disease. However, it is still unclear whether the pathological manifestations observed in slow neurodegenerative diseases are due to neuronal loss or whether they are related to independent degenerative events in the axodendritic network. It also remains elusive whether a single, caspase-based
Volbracht, Christiane, Kolb, Stefan A., Leist, Marcel, Nicotera, Pierluigi   +3 more
openaire   +3 more sources

C-Jun N-terminal kinases/c-Jun and p38 pathways cooperate in ceramide-induced neuronal apoptosis [PDF]

, 2003
Understanding the regulation of the apoptotic program in neurons by intracellular pathways is currently a subject of great interest. Recent results suggest that c-Jun N-terminal kinases (JNK), mitogen-activated protein kinases and the transcription ...
Brugg, B., Caboche, J., Willaime-Morawek, S., Brami-Cherrier, K., Mariani, J.   +4 more
core   +1 more source

Apoptosis of the cerebellar neurons.

Histology and histopathology, 2007
Naturally occurring neuronal death (NOND) is an essential phenomenon during the course of normal development of the nervous system. Studies in vivo and on organotypic cultures have helped to elucidate the basic histological and ultrastructural features, as well as the main cellular mechanisms of NOND in several areas of the brain.
LOSSI, Laura, GAMBINO, Graziana
openaire   +4 more sources

Cortical Neuronal Apoptosis in CADASIL [PDF]

Stroke, 2006
Background and Purpose— Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is caused by mutations of the NOTCH3 gene and is a model of pure vascular dementia.
Anand, Viswanathan, Francoise, Gray, Marie-Germaine, Bousser, Marielle, Baudrimont, Hugues, Chabriat   +4 more
openaire   +2 more sources

Trim17, novel E3 ubiquitin-ligase, initiates neuronal apoptosis [PDF]

, 2010
Accumulating data indicate that the ubiquitin-proteasome system controls apoptosis by regulating the level and the function of key regulatory proteins. In this study, we identified Trim17, a member of the TRIM/RBCC protein family, as one of the critical ...
Rahmeh, R, Magiera, M, Ham, Jonathan, M Kristiansen, Kristiansen, Mark, Ham, J, Desagher, Solange, Lipkin, A, Rahmeh, Rita, Mora, Stéphan, M M Magiera, Vanhille, Laurent, Pettmann, B, Lipkin, Alexey, Mora, S, Kristiansen, M, Robbins, Ian, S Mora, R Rahmeh, A Lipkin, Pettmann, Brigitte, Desagher, S, Lassot, I, Magiera, Maria Magdalena, L Vanhille, Jaudon, F, I Lassot, S Desagher, Jaudon, Fanny, Lassot, Irina, F Jaudon, Vanhille, L, Robbins, I, J Ham, I Robbins, B Pettmann   +35 more
core   +1 more source

ICE, neuronal apoptosis and neurodegeneration [PDF]

Cell Death & Differentiation, 1998
Significant progress has recently occurred in the understanding of the molecular mechanisms mediating vertebrate programmed cell death, or apoptosis. New advances in this field have stemmed from the identification of ICE (caspase-1) as the founding member of the mammalian caspase cell death family.
R M, Friedlander, J, Yuan
openaire   +2 more sources

Repeated isoflurane exposures of neonatal rats contribute to cognitive dysfunction in juvenile animals: the role of miR-497 in isoflurane-induced neurotoxicity

Folia Histochemica et Cytobiologica, 2021
INTRODUCTION: Isoflurane anesthesia at the period of brain development can lead to neurotoxicity and long-term cognitive impairment. This study aimed to investigate the role of miR-497 on isoflurane-induced neurotoxicity.
Yuanyuan Que, Fangxiang Zhang, Jing Peng, Zhuhua Zhang, Duwen Zhang, Minghai He   +5 more
doaj   +1 more source

Role of apoptosis genes in aggression revealed using combined analysis of ANDSystem gene networks, expression and genomic data in grey rats with aggressive behavior

Вавиловский журнал генетики и селекции, 2018
Aggressive behavior in animals plays an important role in protecting the territory, offspring, establishing social hierarchical relations, etc. Increased aggression is observed in a number of diseases ( schizophrenia, bipolar disorder, brain degenerative
A. O. Bragin, O. V. Saik, I. V. Chadaeva, P. S. Demenkov, A. L. Markel, Yu. L. Orlov, E. I.  Rogaev, I. N. Lavrik, V. A. Ivanisenko   +8 more
doaj   +1 more source

Selective HDAC6 inhibitor TubA offers neuroprotection after intracerebral hemorrhage via inhibiting neuronal apoptosis [PDF]

PeerJ, 2023
A large body of evidence has demonstrated that neuronal apoptosis is involved in the pathological process of secondary brain injury following intracerebral hemorrhage (ICH).
Cuiying Peng, Xiyu Gong, Zhiping Hu, Chunli Chen, Zheng Jiang   +4 more
doaj   +2 more sources