Results 41 to 50 of about 1,037,185 (302)

IGF-I protects cortical neurons against ceramide-induced apoptosis via activation of the PI-3K/Akt and ERK pathways; is this protection independent of CREB and Bcl-2?

, 2005
Current understanding of IGF-I-mediated neuroprotection implies the activation of phosphatidylinositol-3-kinase (PI-3K), which leads to the activation of Akt/Protein Kinase B.
Brugg, B., Arbez, N., Willaime-Morawek, S., Mariani, J.   +3 more
core   +1 more source

THE INFECTION EFFECT OF STRAIN H37Rv MYCOBACTERIUM TUBERCULOSIS ON APOPTOSIS OF MICE’S NEURON CELL BRAIN (MUS MUSCULUS)

Malang Neurology Journal, 2016
Background. Mycobacterium tuberculosis (M.tb) may enter into various organs including the central nervous system (CNS) and form the focus of Rich. Tuberculosis infection in the CNS can cause nutritional intake and metabolism in neuronal cells.
Rima Nor Kaspia, Dwi Yuni Nur Hidayati, Aris Widayati   +2 more
doaj   +1 more source

PTEN and AKT/GSK-3β/CRMP-2 signaling pathway are involved in neuronal apoptosis and axonal injury in early brain injury after SAH in rats

Genes and Diseases, 2022
In early brain injury (EBI) after subarachnoid hemorrhage (SAH), white matter (WM) axonal injury plays a key role in the prognosis of the disease. The purpose of this study was to investigate the effects of phosphatase and tensin homolog deleted on ...
Hong Chen, Chao Zhou, Jianfeng Zheng, Zhaosi Zhang, Yongbing Deng, Chongjie Cheng, Zongduo Guo, Gang Huo, Cheng Yin, Xiaochuan Sun   +9 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Neuroprotective effect of hydrogen-rich saline against neurologic damage and apoptosis in early brain injury following subarachnoid hemorrhage: possible role of the Akt/GSK3β signaling pathway.

PLoS ONE, 2014
BackgroundsEarly brain injury (EBI) plays a key role in the pathogenesis of subarachnoid hemorrhage (SAH). Neuronal apoptosis is involved in the pathological process of EBI. Hydrogen can inhibit neuronal apoptosis and attenuate EBI following SAH. However,
Yuan Hong, AnWen Shao, Jianfeng Wang, Sheng Chen, HaiJian Wu, Devin W McBride, Qun Wu, XueJun Sun, JianMin Zhang   +8 more
doaj   +1 more source

The JNK- and AKT/GSK3β- signaling pathways converge to regulate Puma induction and neuronal apoptosis induced by trophic factor deprivation. [PDF]

PLoS ONE, 2012
The AKT, GSK3 and JNK family kinases have been implicated in neuronal apoptosis associated with neuronal development and several neurodegenerative conditions. However, the mechanisms by which these kinase pathways regulate apoptosis remain unclear.
Kristin K Ambacher, Kristen B Pitzul, Meera Karajgikar, Alison Hamilton, Stephen S Ferguson, Sean P Cregan   +5 more
doaj   +1 more source

Photobiomodulation promotes repair following spinal cord injury by restoring neuronal mitochondrial bioenergetics via AMPK/PGC-1α/TFAM pathway

Frontiers in Pharmacology, 2022
Background: Insufficient neuronal mitochondrial bioenergetics supply occurs after spinal cord injury (SCI), leading to neuronal apoptosis and impaired motor function.
Zhijie Zhu, Xuankang Wang, Zhiwen Song, Xiaoshuang Zuo, Yangguang Ma, Zhihao Zhang, Cheng Ju, Zhuowen Liang, Kun Li, Xueyu Hu, Zhe Wang   +10 more
doaj   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

Sinomenine reduces neuronal cell apoptosis in mice after traumatic brain injury via its effect on mitochondrial pathway [PDF]

, 2018
Chuanjing Fu,1,* Qi Wang,2 Xiaofu Zhai,3,* Juemin Gao1 1Department of Neurosurgery, Jiangsu Hospital of Traditional Chinese Medicine, Nanjing, 2Department of Radiology, The Fourth People’s Hospital of Huai’an, 3Department of Neurosurgery ...
Fu C, Wang Q, Juemin Gao, Zhai X, Xiaofu Zhai, Gao J, Qi Wang, Chuanjing Fu   +7 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source