Results 41 to 50 of about 2,763,782 (330)
Frontiers in Genome Editing, 2022 Neuronal differentiation is a complex process whose dysfunction can lead to brain disorders. The development of new tools to target specific steps in the neuronal differentiation process is of paramount importance for a better understanding of the ...
Sara Riccardi +5 more
doaj +1 more source
ZNF281 inhibits neuronal differentiation and is a prognostic marker for neuroblastoma
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance High-risk neuroblastomas (NBs) show undifferentiated/poorly differentiated morphology as a distinctive feature. We have identified the transcription factor ZNF281 as a factor that can counteract the neuronal differentiation of primary ...
M. Pieraccioli +8 more
semanticscholar +1 more source
Proteomic analyses reveal misregulation of LIN28 expression and delayed timing of glial differentiation in human iPS cells with MECP2 loss-of-function. [PDF]
, 2019 Rett syndrome (RTT) is a pervasive developmental disorder caused by mutations in MECP2. Complete loss of MECP2 function in males causes congenital encephalopathy, neurodevelopmental arrest, and early lethality.
Carromeu, Cassiano +9 more
core +2 more sources
Molecular Neurobiology, 2018 POU-homeodomain transcription factor POU3F2 is a critical transcription factor that participates in neuronal differentiation. However, little is known about its downstream mediators.
Yi-Mei J. Lin +9 more
semanticscholar +1 more source
Local and global spontaneous calcium events regulate neurite outgrowth and onset of GABAergic phenotype during neural precursor differentiation [PDF]
, 2003 Neural stem cells can generate in vitro progenitors of the three main cell lineages found in the CNS. The signaling pathways underlying the acquisition of differentiated phenotypes in these cells are poorly understood.
Berridge, Michael J. +5 more
core +1 more source
Metabolic reprogramming during neuronal differentiation
Cell Death and Differentiation, 2016 Newly generated neurons pass through a series of well-defined developmental stages, which allow them to integrate into existing neuronal circuits. After exit from the cell cycle, postmitotic neurons undergo neuronal migration, axonal elongation, axon ...
M. Agostini +12 more
semanticscholar +1 more source
Ionizing Radiation Induces Altered Neuronal Differentiation by mGluR1 through PI3K-STAT3 Signaling in C17.2 Mouse Neural Stem-Like Cells. [PDF]
PLoS ONE, 2016 Most studies of IR effects on neural cells and tissues in the brain are still focused on loss of neural stem cells. On the other hand, the effects of IR on neuronal differentiation and its implication in IR-induced brain damage are not well defined.
Hyeon Soo Eom +6 more
doaj +1 more source
eLife, 2022 Reconstruction of prototypic three-dimensional (3D) atlases at the scale of whole tissues or organs requires specific methods to be developed. We have established a digital 3D-atlas maker (DAMAKER) and built a digital 3D-atlas to monitor the changes in ...
Matthias Blanc +3 more
doaj +1 more source
Multi-scale engineering for neuronal cell growth and differentiation [PDF]
, 2011 In this paper we investigate the role of micropatterning and molecular coating for cell culture and differentiation of neuronal cells (Neuro2a cell line) on a polydimethylsiloxane substrate.
Béduer, Amélie +5 more
core +3 more sources
Nature Communications, 2017 Mutations in chromatin modifier genes are frequently associated with neurodevelopmental diseases. We herein demonstrate that the chromodomain helicase DNA-binding protein 7 (Chd7), frequently associated with CHARGE syndrome, is indispensable for normal ...
Weijun Feng +25 more
semanticscholar +1 more source