Results 51 to 60 of about 2,763,782 (330)

iASPP regulates neurite development by interacting with Spectrin proteins

Frontiers in Molecular Neuroscience, 2023
IntroductionSince its discovery in 1999, a substantial body of research has shown that iASPP is highly expressed in various kinds of tumors, interacts with p53, and promotes cancer cell survival by antagonizing the apoptotic activity of p53. However, its
Junhao Wang, Chunhong Jia, Qiong Gao, Jiwen Zhang, Xi Gu   +4 more
doaj   +1 more source

Transcriptomic signatures of neuronal differentiation and their association with risk genes for autism spectrum and related neuropsychiatric disorders. [PDF]

, 2016
Genes for autism spectrum disorders (ASDs) are also implicated in fragile X syndrome (FXS), intellectual disabilities (ID) or schizophrenia (SCZ), and converge on neuronal function and differentiation. The SH-SY5Y neuroblastoma cell line, the most widely
Chiocchetti, AG, Cocchi, E, de la Torre-Ubieta, L, Freitag, CM, Fulda, S, Geschwind, DH, Haslinger, D, Lindlar, S, Rothämel, T, Stein, JL, Waltes, R   +10 more
core   +1 more source

Octadecaneuropeptide (ODN) Induces N2a Cells Differentiation through a PKA/PLC/PKC/MEK/ERK-Dependent Pathway: Incidence on Peroxisome, Mitochondria, and Lipid Profiles

Molecules, 2019
Neurodegenerative diseases are characterized by oxidative stress, mitochondrial damage, and death of neuronal cells. To counteract such damage and to favor neurogenesis, neurotrophic factors could be used as therapeutic agents. Octadecaneuropeptide (ODN),
Amira Namsi, Thomas Nury, Amira. S. Khan, Jérôme Leprince, David Vaudry, Claudio Caccia, Valerio Leoni, Atanas G. Atanasov, Marie-Christine Tonon, Olfa Masmoudi-Kouki, Gérard Lizard   +10 more
doaj   +1 more source

Co-transplantation of Human Embryonic Stem Cell-derived Neural Progenitors and Schwann Cells in a Rat Spinal Cord Contusion Injury Model Elicits a Distinct Neurogenesis and Functional Recovery [PDF]

Co-transplantation of neural progenitors (NPs) with Schwann cells (SCs) might be a way to overcome low rate of neuronal differentiation of NPs following transplantation in spinal cord injury (SCI) and the improvement of locomotor recovery. In this study,
Ali Niapour, Ao Q., Baharvand H., Basso D. M., Beattie M. S., Ben-Hur T., Biernaskie J., Blakemore W. F., Bradbury E. J., Brierley C. M., Bruce J. H., Calella A. M., Cao Q. L., Cao Q. L., Castellanos D. A., Cho S. R., Cohen M. A., Cui L., Cummings B. J., Daadi M. M., David S., Deng Y. B., Deshpande D. M., Dhara S. K., Ernsberger U., Fereshteh Karamali, Fouad K., Gage F. H., Golden K. L., Gruner J. A., Haruta M., Hatami M., Hill C. E., Hofstetter C. P., Hong S., Hossein Baharvand, Islam O., Iwanami A., Joannides A. J., Joannides A. J., Kamada T., Kamei N., Karimi-Abdolrezaee S., Kerr D. A., Keyvan-Fouladi N., Kimura H., Koch P., Kumagai G., Li J., Lim M. S., Lindvall O., Livak K. J., Lu P., Lund R. D., Madhavan L., McDonald J. W., Menei P., Meng X. T., Mohammad Hossein Nasr-Esfahani, Mohammad Mardani, Mollamohammadi S., Murray M., Nemati S., Niapour A., Okada S., Olson H. E., Pal R., Papastefanaki F., Parati E. A., Park D. H., Parr A. M., Pearse D. D., Pearse D. D., Pfeifer K., Pincus D. W., Ramer L. M., Roy N. S., Salehi M., Sasaki M., Shin S., Shiva Nemati, Smith R., Takami T., Tetzlaff W., Thuret S., Tobias C. A., Tsuji O., Vargas M. E., Wang G., Webber D. J., Widenfalk J., Willerth S. M., Yan J., Yan J., Zahra Taghipour, Zeng Y. S., Zhang X., Zhang Y. Q.   +97 more
core   +2 more sources

Atg5 and Ambra1 differentially modulate neurogenesis in neural stem cells [PDF]

, 2012
Neuroepithelial cells undergoing differentiation efficiently remodel their cytoskeleton and shape in an energy-consuming process. The capacity of autophagy to recycle cellular components and provide energy could fulfill these requirements, thus ...
Arroba, A, Boya, P, Cecconi, F, De La Rosa, E, De Pablo, F, Vázquez, P   +5 more
core   +2 more sources

Neuronal differentiation is associated with a redox-regulated increase of copper flow to the secretory pathway

Nature Communications, 2016
Brain development requires a fine-tuned copper homoeostasis. Copper deficiency or excess results in severe neuro-pathologies. We demonstrate that upon neuronal differentiation, cellular demand for copper increases, especially within the secretory pathway.
Yuta Hatori, Ye Yan, Katharina Schmidt, Eri Furukawa, Nesrin M. Hasan, Nan Yang, Chin-Nung Liu, S. Sockanathan, S. Lutsenko   +8 more
semanticscholar   +1 more source

Involvement of the Acyl-CoA binding domain containing 7 in the control of food intake and energy expenditure in mice

eLife, 2016
Acyl-CoA binding domain-containing 7 (Acbd7) is a paralog gene of the diazepam-binding inhibitor/Acyl-CoA binding protein in which single nucleotide polymorphism has recently been associated with obesity in humans.
Damien Lanfray, Alexandre Caron, Marie-Claude Roy, Mathieu Laplante, Fabrice Morin, Jérôme Leprince, Marie-Christine Tonon, Denis Richard   +7 more
doaj   +1 more source

Upregulation of Apol8 by Epothilone D facilitates the neuronal relay of transplanted NSCs in spinal cord injury

Stem Cell Research & Therapy, 2021
Background Microtubule-stabilizing agents have been demonstrated to modulate axonal sprouting during neuronal disease. One such agent, Epothilone D, has been used to treat spinal cord injury (SCI) by promoting axonal sprouting at the lesion site after ...
Weiwei Xue, Haipeng Zhang, Yongheng Fan, Zhifeng Xiao, Yannan Zhao, Weiyuan Liu, Bai Xu, Yanyun Yin, Bing Chen, Jiayin Li, Yi Cui, Ya Shi, Jianwu Dai   +12 more
doaj   +1 more source

Transmitochondrial embryonic stem cells containing pathogenic mtDNA mutations are compromised in neuronal differentiation [PDF]

, 2009
Objectives:  Defects of the mitochondrial genome (mtDNA) cause a series of rare, mainly neurological disorders. In addition, they have been implicated in more common forms of movement disorders, dementia and the ageing process.
Acin-Perez, Rebecca, Enriquez, Jose, Kirby, Denise, Lightowlers, Robert, Rennie, Katherine, Smulders-Srinivasan, Tora, Trevelyan, Andrew, Turnbull, Doug, Whittington, Miles   +8 more
core   +2 more sources

Caveolin-1 plays a crucial role in inhibiting neuronal differentiation of neural stem/progenitor cells via VEGF signaling-dependent pathway. [PDF]

PLoS ONE, 2011
In the present study, we aim to elucidate the roles of caveolin-1(Cav-1), a 22 kDa protein in plasma membrane invaginations, in modulating neuronal differentiation of neural progenitor cells (NPCs).
Yue Li, Jianmin Luo, Wui-Man Lau, Guoqing Zheng, Shuping Fu, Ting-Ting Wang, He-Ping Zeng, Kwok-Fai So, Sookja Kim Chung, Yao Tong, Kejian Liu, Jiangang Shen   +11 more
doaj   +1 more source