The Primary Cilium and Neuronal Migration
Cells, 2022 The primary cilium (PC) is a microtubule-based tiny sensory organelle emanating from the centrosome and protruding from the surface of most eukaryotic cells, including neurons.
Julie Stoufflet, Isabelle Caillé
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Putative cell adhesion membrane protein Vstm5 regulates neuronal morphology and migration in the central nervous system [PDF]
, 2016 During brain development, dynamic changes in neuronal membranes perform critical roles in neuronal morphogenesis and migration to create functional neural circuits.
Ko, Kwang Woo +5 more
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Mechanisms of Development, 2001 Like other motile cells, neurons migrate in three schematic steps, namely leading edge extension, nuclear translocation or nucleokinesis, and retraction of the trailing process. In addition, neurons are ordered into architectonic patterns at the end of migration. Leading edge extension can proceed at the extremity of the axon, by growth cone formation,
Lambert De Rouvroit, Catherine +1 more
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Early Acquisition of Neural Crest Competence During hESCs Neuralization [PDF]
, 2010 Background: Neural crest stem cells (NCSCs) are a transient multipotent embryonic cell population that represents a defining characteristic of vertebrates.
Bronner-Fraser, Marianne +8 more
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CDYL Deficiency Disrupts Neuronal Migration and Increases Susceptibility to Epilepsy
Cell Reports, 2017 Summary: During brain development, the correct migration of newborn neurons is one of the determinants of circuit formation, and neuronal migration defects may lead to neurological and psychiatric disorders.
Rui Qin +5 more
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A Common Variant Associated with Dyslexia Reduces Expression of the KIAA0319 Gene [PDF]
, 2009 Numerous genetic association studies have implicated the KIAA0319 gene on human chromosome 6p22 in dyslexia susceptibility. The causative variant(s) remains unknown but may modulate gene expression, given that (1) a dyslexia-associated haplotype has been
Megan Y. Dennis +67 more
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Toward a Better Understanding of Neuronal Migration Deficits in Autism Spectrum Disorders
Frontiers in Cell and Developmental Biology, 2019 Newborn neurons in developing brains actively migrate from germinal zones to designated regions before being wired into functional circuits. The motility and trajectory of migrating neurons are regulated by both extracellular factors and intracellular ...
Yi-Hsuan Pan +3 more
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Neuronal Migration During Development of the Cerebellum
Frontiers in Cellular Neuroscience, 2018 Neuronal migration is a fundamental process in central nervous system (CNS) development. The assembly of functioning neuronal circuits relies on neuronal migration occurring in the appropriate spatio-temporal pattern.
Maryam Rahimi-Balaei +5 more
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Foxp1 and lhx1 coordinate motor neuron migration with axon trajectory choice by gating Reelin signalling. [PDF]
, 2010 Topographic neuronal maps arise as a consequence of axon trajectory choice correlated with the localisation of neuronal soma, but the identity of the pathways coordinating these processes is unknown.
Kania, Artur +8 more
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A developmental and genetic classification for malformations of cortical development: update 2012. [PDF]
, 2012 Malformations of cerebral cortical development include a wide range of developmental disorders that are common causes of neurodevelopmental delay and epilepsy. In addition, study of these disorders contributes greatly to the understanding of normal brain
Barkovich, A James +4 more
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