Results 31 to 40 of about 2,639,581 (370)
Role of Keratinocytes in Sensitive Skin
Frontiers in Medicine, 2019 Sensitive skin is a clinical syndrome defined by the occurrence of unpleasant sensations such as burning, stinging, tingling, pricking, or itching in response to various normally innocuous physical, chemical, and thermal stimuli.
Matthieu Talagas +3 more
doaj +1 more source
Scientific Validation of Human Neurosphere Assays for Developmental Neurotoxicity Evaluation
Frontiers in Toxicology, 2022 There is a call for a paradigm shift in developmental neurotoxicity (DNT) evaluation, which demands the implementation of faster, more cost-efficient, and human-relevant test systems than current in vivo guideline studies.
Katharina Koch +10 more
doaj +1 more source
Dendritic action potentials and computation in human layer 2/3 cortical neurons
Science, 2020 Human dendrites are special A special developmental program in the human brain drives the disproportionate thickening of cortical layer 2/3. This suggests that the expansion of layer 2/3, along with its numerous neurons and their large dendrites, may ...
A. Gidon +8 more
semanticscholar +1 more source
nNOS(+) striatal neurons, a subpopulation spared in Huntington's Disease, possess functional NMDA receptors but fail to generate mitochondrial ROS in response to an excitotoxic challenge. [PDF]
, 2013 Huntington's disease (HD) is a neurodegenerative condition characterized by severe neuronal loss in the cortex and striatum that leads to motor and behavioral deficits.
Canzoniero, Lorella MT +5 more
core +2 more sources
Physica A: Statistical Mechanics and its Applications, 2023 21 pages, 32 figures. A preprint of a work submitted to a scientific journal (first revision)
openaire +2 more sources
Single-protein detection in crowded molecular environments in cryo-EM images
eLife, 2017 We present an approach to study macromolecular assemblies by detecting component proteins’ characteristic high-resolution projection patterns, calculated from their known 3D structures, in single electron cryo-micrographs.
J Peter Rickgauer +2 more
doaj +1 more source
Identifying specific prefrontal neurons that contribute to autism-associated abnormalities in physiology and social behavior. [PDF]
, 2017 Functional imaging and gene expression studies both implicate the medial prefrontal cortex (mPFC), particularly deep-layer projection neurons, as a potential locus for autism pathology.
Brumback, AC +9 more
core +1 more source
Virology Journal, 2011 Background The NS1 protein of influenza A virus is able to bind with many proteins that affect cellular signal transduction and protein synthesis in infected cells.
Xu Yanxuan +7 more
doaj +1 more source
Direct conversion of fibroblasts to functional neurons by defined factors
Nature, 2010 Cellular differentiation and lineage commitment are considered to be robust and irreversible processes during development. Recent work has shown that mouse and human fibroblasts can be reprogrammed to a pluripotent state with a combination of four ...
Thomas Vierbuchen +5 more
semanticscholar +1 more source