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Dorsal root ganglion macrophages contribute to both the initiation and persistence of neuropathic pain [PDF]
Nature Communications, 2020 Paralleling the activation of dorsal horn microglia after peripheral nerve injury is a significant expansion and proliferation of macrophages around injured sensory neurons in dorsal root ganglia (DRG).
Xiaobing Yu +8 more
semanticscholar +4 more sources
Epidemiology of neuropathic pain: an analysis of prevalence and associated factors in UK Biobank
PAIN Reports, 2023 Supplemental Digital Content is Available in the Text. An analysis of UK Biobank participants who completed a detailed pain questionnaire identified factors associated with neuropathic pain (NeuP) vs no chronic pain and non-NeuP and estimated the ...
G. Baskozos +7 more
semanticscholar +1 more source
Brain : a journal of neurology, 2022 Neuropathic pain is a leading cause of high impact pain, is often disabling and is poorly managed by current therapeutics. Here we focused on a unique group of neuropathic pain patients undergoing thoracic vertebrectomy where the dorsal root ganglia is ...
P. Ray +12 more
semanticscholar +1 more source
Cell Research, 2021 Peripheral nerve injury could lead to chronic neuropathic pain. Understanding transcriptional changes induced by nerve injury could provide fundamental insights into the complex pathogenesis of neuropathic pain.
Kaikai Wang +9 more
semanticscholar +1 more source
Potential for increased prevalence of neuropathic pain after the COVID-19 pandemic
PAIN Reports, 2021 This review focuses on the neurological complications of COVID-19 including Guillain–Barré syndrome, myelitis, and stroke with regards to their potential risk of chronic neuropathic pain.
N. Attal, V. Martinez, D. Bouhassira
semanticscholar +1 more source
Cannabis-Based Medicines and Medical Cannabis for Chronic Neuropathic Pain
CNS Drugs, 2021 Neuropathic pain represents a broad category of pain syndromes that include a wide variety of peripheral and central disorders. The overall prevalence of neuropathic pain in the general population is reported to be between 7 and 10%.
F. Petzke +3 more
semanticscholar +1 more source
Exercise and Neuropathic Pain: A General Overview of Preclinical and Clinical Research
Sports Medicine - Open, 2021 Neuropathic pain is a disease of the somatosensory system that is characterized by tingling, burning, and/or shooting pain. Medication is often the primary treatment, but it can be costly, thus there is an interest in understanding alternative low-cost ...
B. Leitzelar, K. Koltyn
semanticscholar +1 more source
Diabetic neuropathy and neuropathic pain: a (con)fusion of pathogenic mechanisms?
Pain, 2020 Neuropathy is a common complication of long-term diabetes that impairs quality of life by producing pain, sensory loss and limb amputation. The presence of neuropathy in both insulin-deficient (type 1) and insulin resistant (type 2) diabetes along with ...
N. Calcutt
semanticscholar +1 more source
Pain, 2020 Neuropathic pain is a complex, heterogeneous disorder that affects approximately 8% of the total adult human population and comeswith significant burden for both the patient and health care system.
E. Joosten, Glenn Franken
semanticscholar +1 more source
Challenges of neuropathic pain: focus on diabetic neuropathy
Journal of neural transmission, 2020 Neuropathic pain is a frequent condition caused by a lesion or disease of the central or peripheral somatosensory nervous system. A frequent cause of peripheral neuropathic pain is diabetic neuropathy.
D. Rosenberger +4 more
semanticscholar +1 more source