Results 1 to 10 of about 1,790,764 (256)

Dorsal root ganglion macrophages contribute to both the initiation and persistence of neuropathic pain. [PDF]

Nature Communications, 2020
Paralleling the activation of dorsal horn microglia after peripheral nerve injury is a significant expansion and proliferation of macrophages around injured sensory neurons in dorsal root ganglia (DRG).
Basbaum, Allan I, Braz, Joao M, Guan, Zhonghui, Hamel, Katherine A, Leff, Jacqueline, Liu, Hongju, Morvan, Maelig G, Yu, Stephen, Yu, Xiaobing   +8 more
core   +3 more sources

An Epidemiological Study of Neuropathic Pain Symptoms in Canadian Adults [PDF]

Pain Research and Management, 2016
The reported prevalence of neuropathic pain ranges from 6.9% to 10%; however the only Canadian study reported 17.9%. The objective of this study was to describe the epidemiology of neuropathic pain in Canada.
Elizabeth G. VanDenKerkhof, Elizabeth G. Mann, Nicola Torrance, Blair H. Smith, Ana Johnson, Ian Gilron   +5 more
doaj   +7 more sources

Protein Kinases as Mediators for miRNA Modulation of Neuropathic Pain [PDF]

Cells
Neuropathic pain is a chronic condition resulting from injury or dysfunction in the somatosensory nervous system, which leads to persistent pain and a significant impairment of quality of life.
Leah Chang, Zala Čok, Lei Yu
doaj   +2 more sources

Can treatment success with 5% lidocaine medicated plaster be predicted in cancer pain with neuropathic components or trigeminal neuropathic pain? [PDF]

Journal of Pain Research, 2013
Kai-Uwe Kern,1 Srinivas Nalamachu,2 Louis Brasseur,3 Joanna M Zakrzewska4 1Institute for Pain Medicine, Wiesbaden, Germany; 2International Clinical Research Institute, Overland Park, KS, USA; 3Institut Curie, Saint Cloud, France; 4Eastman Dental Hospital,
Kern KU, Nalamachu S, Brasseur L, Zakrzewska JM   +3 more
doaj   +3 more sources

Emerging Role of Schwann Cells in Neuropathic Pain: Receptors, Glial Mediators and Myelination

Frontiers in Cellular Neuroscience, 2019
Neuropathic pain caused by nerve injury or disease remains a major challenge for modern medicine worldwide. Most of the pathogenic mechanisms underlying neuropathic pain are centered on neuronal mechanisms.
Gang Chen
exaly   +2 more sources

CXCL12/CXCR4 signaling contributes to neuropathic pain via central sensitization mechanisms in a rat spinal nerve ligation model

CNS Neuroscience and Therapeutics, 2019
Previous studies have demonstrated that the CXCL12/CXCR4 signaling axis is involved in the regulation of neuropathic pain (NP). Here, we performed experiments to test whether the CXCL12/CXCR4 signaling pathway contributes to the pathogenesis of ...
Zhi-yuan Liu, Zhi-wen Song, Li-ming Shen
exaly   +2 more sources

Epidemiology of neuropathic pain: an analysis of prevalence and associated factors in UK Biobank

PAIN Reports, 2023
Supplemental Digital Content is Available in the Text. An analysis of UK Biobank participants who completed a detailed pain questionnaire identified factors associated with neuropathic pain (NeuP) vs no chronic pain and non-NeuP and estimated the ...
G. Baskozos, H. Hébert, Mathilde M V Pascal, Andreas C Themistocleous, G. Macfarlane, D. Wynick, David L H Bennett, Blair H. Smith   +7 more
semanticscholar   +1 more source

RNA profiling of human dorsal root ganglia reveals sex-differences in mechanisms promoting neuropathic pain.

Brain : a journal of neurology, 2022
Neuropathic pain is a leading cause of high impact pain, is often disabling and is poorly managed by current therapeutics. Here we focused on a unique group of neuropathic pain patients undergoing thoracic vertebrectomy where the dorsal root ganglia is ...
P. Ray, Stephanie I. Shiers, James P Caruso, Diana Tavares-Ferreira, Ishwarya Sankaranarayanan, Megan L. Uhelski, Yan Li, Robert Y. North, C. Tatsui, G. Dussor, M. Burton, P. Dougherty, Theodore John Price   +12 more
semanticscholar   +1 more source

Comparing objective cognitive impairments in patients with peripheral neuropathic pain or fibromyalgia

Scientific Reports, 2021
Existing studies on cognitive impairments in chronic pain do not investigate peripheral neuropathic pain (PNP) or compare pain conditions in a satisfactory manner. Here we aimed to compare executive dysfunctions in PNP patients with fibromyalgia (FM) and
Henrik Børsting Jacobsen, Tore C. Stiles, Audun Stubhaug, Nils Inge Landrø, Per Hansson   +4 more
doaj   +1 more source

Enriched enrollment randomized double-blind placebo-controlled cross-over trial with phenytoin cream in painful chronic idiopathic axonal polyneuropathy (EPHENE): a study protocol

Trials, 2022
Background Patients with chronic idiopathic axonal polyneuropathy (CIAP) can have neuropathic pain that significantly impacts quality of life. Oral neuropathic pain medication often has insufficient pain relief and side effects.
David J. Kopsky, Ruben P. A. van Eijk, Janna K. Warendorf, Jan M. Keppel Hesselink, Nicolette C. Notermans, Alexander F. J. E. Vrancken   +5 more
doaj   +1 more source