Advanced Science, EarlyView.How locus coeruleus noradrenergic‐spinal projections and subsequent α2A adrenoceptors‐CaMKII signaling cascades contribute to electroacupuncture‐induced antinociception in postoperative pain in mice is described. Abstract Postoperative pain remains a significant challenge in healthcare.
Wen‐Guang Chu +13 more
wiley +1 more source
Multidimensional pain phenotypes after Traumatic Brain Injury
Frontiers in Pain Research, 2022 More than 50% of individuals develop chronic pain following traumatic brain injury (TBI). Research suggests that a significant portion of post-TBI chronic pain conditions is neuropathic in nature, yet the relationship between neuropathic pain ...
Linda E. Robayo +12 more
doaj +1 more source
Alkali burn induced corneal spontaneous pain and activated neuropathic pain matrix in the central nerve system in mice [PDF]
, 2017 Purpose: To explore whether alkali burn causes corneal neuropathic pain and activates neuropathic pain matrix in the central nerve system in mice. Methods: A corneal alkali burn mouse model (grade II) was used.
Gao, Feng +8 more
core +1 more source
Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine
Advanced Science, EarlyView.Neural organoids provide a versatile platform for neurological research. Advances in organoid technology have partially achieved human neural tissue complexity in terms of tissue structure, cell diversity, and neural signaling, offering insights into neural disorders and regenerative strategies. Technology advances from biomaterials, bio‐manufacturing,
Ruiqi Huang +4 more
wiley +1 more source
Translational investigation and treatment of neuropathic pain
Molecular Pain, 2012 Neuropathic pain develops from a lesion or disease affecting the somatosensory system. Translational investigations of neuropathic pain by using different animal models reveal that peripheral sensitization, spinal and cortical plasticity may play ...
Xu Bo +4 more
doaj +1 more source
Comparison of analgesic effects and patient tolerability of nabilone and dihydrocodeine for chronic neuropathic pain: randomised, crossover, double blind study [PDF]
, 2008 <b>Objective</b>: To compare the analgesic efficacy and side effects of the synthetic cannabinoid nabilone with those of the weak opioid dihydrocodeine for chronic neuropathic pain.
Frank, B. +4 more
core +2 more sources
Nano‐Anesthetics Regulate Neuro‐Immune Interaction for Treating Neuropathic Pain
Advanced Science, EarlyView.Ce‐UiO‐66‐Bupivacaine (CUB) demonstrates triple therapeutic innovation: 1) Sustained analgesia with ROS scavenging synergistically resolves neuropathic pain; 2) Microglia/astrocyte polarization switch reprograms the pro‐regenerative immune microenvironment; 3) CGRP‐TSP‐1 axis activation couples inflammation suppression to axon regeneration, defining a ...
Yue Wang +9 more
wiley +1 more source
Comparative analysis of chronic neuropathic pain and pain assessment in companion animals and humans
Frontiers in Veterinary ScienceChronic neuropathic pain is underdiagnosed in companion animals. This paper will review the definition of pain and how classification and grading of neuropathic pain can be applied from human to veterinary medicine to increase the recognition of and the ...
Rell L. Parker
doaj +1 more source
Neuropathic Pain Related to Peripheral Neuropathies According to the IASP Grading System Criteria
Brain Sciences, 2020 Neuropathic pain is defined as pain caused by a lesion or disease of the somatosensory system. Neuropathic pain represents a broad category of pain conditions, common complications of peripheral neuropathies, which are characterized by a combination of ...
Giulia Di Stefano +3 more
doaj +1 more source
Use of anticonvulsants drugs for neuropathic painful conditions [PDF]
, 2008 Neuropathic pain, a form of chronic pain initiated and sustained by an insult to the peripheral or central nervous system, is a challenge to clinicians as it does not respond well to traditional pain therapies.
Afshan, Gauhar, Hussain, Aziza Mohammad
core +1 more source