Results 121 to 130 of about 1,706,564 (357)

Cannabinoids From Trema micranthum (L.) Blume (Cannabaceae): A Cannabinoid Profiling System

open access: yesChemistry &Biodiversity, EarlyView.
ABSTRACT Trema micranthum (L.) Blume is a species from the Cannabaceae botanical family, present all over the tropics. A recent study conducted by our group identified the presence of cannabidiol (CBD), Δ9‐tetrahydrocannabinol, cannabidiolic acid, and tetrahydrocannabinolic acid‐A in T. micranthum extracts.
Yasmin Cunha‐Silva   +7 more
wiley   +1 more source

TLR8 and its endogenous ligand miR-21 contribute to neuropathic pain in murine DRG

open access: yesJournal of Experimental Medicine, 2018
Toll-like receptors (TLRs) are nucleic acid–sensing receptors and have been implicated in mediating pain and itch. Here we report that Tlr8−/− mice show normal itch behaviors, but have defects in neuropathic pain induced by spinal nerve ligation (SNL) in
Zhi-jun Zhang   +11 more
semanticscholar   +1 more source

Neuropathic Pain

open access: yesSouthern African Journal of Anaesthesia and Analgesia, 2002
No Abstract.
openaire   +2 more sources

Volatilome and Antinociceptive Activity of the Traditional Preparation and Compounds from Ageratina grandifolia (Regel) R.M. King & H. Rob.

open access: yesChemistry &Biodiversity, EarlyView.
Abstract An infusion of Ageratina grandifolia, a traditional preparation, and major compounds [3,5‐diprenyl‐4‐hydroxyacetophenone (1), O‐methylencecalinol (2), encecalin (3), and encecalinol (4)], tested at 10, 31.6, and 100 mg/kg, intragastrically administered, showed a significant antinociceptive effect in both phases of the formalin test in mice ...
José Alberto Gutiérrez‐González   +5 more
wiley   +1 more source

The etiological contribution of GABAergic plasticity to the pathogenesis of neuropathic pain

open access: yesMolecular Pain, 2019
Neuropathic pain developing after peripheral or central nerve injury is the result of pathological changes generated through complex mechanisms. Disruption in the homeostasis of excitatory and inhibitory neurons within the central nervous system is a ...
Caijuan Li   +7 more
semanticscholar   +1 more source

Implementing Pre‐Emptive Pharmacogenetics: Impact of Early Pharmacogenetic Screening in a Pediatric Oncology Cohort of 1,151 Subjects

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
In pediatric oncology, pharmacogenetic guidelines are underutilized and the potential impact of pre‐emptive pharmacogenetic screening remains largely unexplored despite this field's need for individualized approaches. While comprehensive pharmacogenetic guidelines are not yet available for all anticancer drugs, evidence‐based recommendations exist for ...
Emma C. Bernsen   +12 more
wiley   +1 more source

Neuropathic pain evaluation tools

open access: yesRevista Dor
BACKGROUND AND OBJECTIVES: Pain is a subjective symptom which may be measured by means of its several features, such as intensity, quality, location, duration and impact on daily activities.
Fabiola Dach Eckeli   +2 more
doaj   +1 more source

miRNA-23a/CXCR4 regulates neuropathic pain via directly targeting TXNIP/NLRP3 inflammasome axis

open access: yesJournal of Neuroinflammation, 2018
Chemokine CXC receptor 4 (CXCR4) in spinal glial cells has been implicated in neuropathic pain. However, the regulatory cascades of CXCR4 in neuropathic pain remain elusive.
Zhiqiang Pan   +8 more
semanticscholar   +1 more source

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