Possible role of spinal astrocytes in maintaining chronic pain sensitization: review of current evidence with focus on bFGF/JNK pathway [PDF]
, 2006 Although pain is regarded traditionally as neuronally mediated, recent progress shows an important role of spinal glial cells in persistent pain sensitization.
Decosterd, I. +4 more
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Animal Models and Experimental Medicine, EarlyView.Multiple low dose streptozotocin‐induced diabetes is a valuable animal model of diabetes type 1. It should be improved by further research on autoantigens, microbiota and mucosal immune cells from the gut, but also from other organs. Abstract The autoimmune response directed against pancreatic β cells is the most essential pathogenic process in type 1 ...
Ivan Koprivica +4 more
wiley +1 more source
Loss of neurons from laminas I-III of the spinal dorsal horn is not required for development of tactile allodynia in the spared nerve injury model of neuropathic pain [PDF]
, 2005 It has been proposed that death of inhibitory interneurons in the dorsal horn contributes to the neuropathic pain that follows partial nerve injury. In this study, we have used two approaches to test whether there is neuronal death in the dorsal horn in ...
Arham, A.Z. +3 more
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Toward Natural Limb Function: A New Era in Prosthetic Innovation
Annals of Neurology, EarlyView.The past decade has witnessed groundbreaking clinical implementation of neuroprosthetic limbs driven by signals from peripheral targets (eg, nerves and muscle) and the brain to restore limb function for individuals with limb loss or impairment. In this review, we highlight recent key clinical trials in peripheral neuroprosthetic interfaces directly ...
Yucheng Tian +4 more
wiley +1 more source
From acute to chronic pain: tapentadol in the progressive stages of this disease entity [PDF]
, 2017 OBJECTIVE: Chronic pain is now recognized as a neural disease, which results from a maladaptive functional and structural transformation process occurring over time. In its chronic phase, pain is not just a symptom but also a disease entity.
Coluzzi, Flaminia +3 more
core
Current status and future directions of botulinum neurotoxins for targeting pain processing. [PDF]
, 2015 Current evidence suggests that botulinum neurotoxins (BoNTs) A1 and B1, given locally into peripheral tissues such as skin, muscles, and joints, alter nociceptive processing otherwise initiated by inflammation or nerve injury in animal models and humans.
Pellett, Sabine +2 more
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A study of pain threshold in diabetics with neuropathic foot lesions. [PDF]
, 1986 Pamela M. Le Quesne, Clare J. Fowler
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Biallelic Variants in the DARS2 Gene as a Novel Cause of Axonal Charcot–Marie–Tooth Disease
Annals of Neurology, EarlyView.Objective Charcot–Marie–Tooth (CMT) disease is a heterogeneous group of genetic neuropathies, with >90 genes identified. Several aminoacyl‐tRNA synthetases have been linked to CMT. DARS2, encoding the mitochondrial aspartyl‐tRNA synthetase, has been typically associated with leukoencephalopathy with brainstem and spinal cord involvement and lactate ...
Berta Estévez‐Arias +23 more
wiley +1 more source
Diagnostics and therapy of peripheral neuropathy (literature review)
Acta Biomedica Scientifica, 2015 The review is devoted to diagnostics and treatment of neuropathic pain in patients with peripheral nervous system diseases. Main assessment tools are shown including Visual analog Scale (VAS), Neuropathic Pain Scale (NPS), Leeds Assessment of Neuropathic
G. Y. Levina, Y. N. Bykov, A. S. Borisov
doaj
Neuropathic Pain Can Be Relieved by Drugs That Are Use-dependent Sodium Channel Blockers [PDF]
, 1991 Darrell L. Tanelian, William G. Brose
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