A randomized placebo-controlled pilot study of the efficacy and safety of D-cycloserine in people with chronic back pain. [PDF]
, 2016 BACKGROUND: Few effective pharmacological treatment options exist for chronic back pain, the leading cause of disability in the US, and all are associated with significant adverse effects. OBJECTIVE: To determine the efficacy and safety of D-cycloserine,
Apkarian, A. Vania +5 more
core +2 more sources
Cross-sectional comparison of cannabis use in adults with neuropathic versus non-neuropathic pain
Frontiers in Pain ResearchIntroductionCannabis has been decriminalized by many states and shows promise in treating both neuropathic and non-neuropathic pain through its interaction with the endocannabinoid system and anti-inflammatory effects.
Carl Joshua P. Laroya +7 more
doaj +1 more source
Lysophosphatidic acid is associated with neuropathic pain intensity in humans: An exploratory study.
PLoS ONE, 2018 The underlying mechanisms of neuropathic pain remain to be elucidated. Basic animal research has suggested that lysophosphatidic acids, which are bioactive lipids produced by autotaxin from lysophosphatidylcholine, may play key roles in the initiation ...
Ken Kuwajima +10 more
doaj +1 more source
Surgical treatment of neuropathic pain [PDF]
, 2013 Neuropathic pain (NP) is a transient dysfunction caused by the damage of peripheral nerve and central nervous system, characterized with hyperalgesia, allodynia and spontaneous pain.
Zhi-pei LING, Zhi-qiang CUI
core +1 more source
Motor cortex electric stimulation for the treatment of neuropathic pain
Arquivos de Neuro-Psiquiatria, 2010 OBJECTIVE: Motor cortex stimulation (MCS) is considered to be an effective treatment for chronic neuropathic pain. The aim of the present study was to assess the efficacy of MCS for treating neuropathic pain.
Walter J. Fagundes-Pereyra +6 more
doaj +1 more source
Inter-strain differences of serotonergic inhibitory pain control in inbred mice [PDF]
, 2010 Background: Descending inhibitory pain control contributes to the endogenous defense against chronic pain and involves noradrenergic and serotonergic systems.
Wijnvoord, Nina +5 more
core +2 more sources
Comparative analysis of chronic neuropathic pain and pain assessment in companion animals and humans
Frontiers in Veterinary ScienceChronic neuropathic pain is underdiagnosed in companion animals. This paper will review the definition of pain and how classification and grading of neuropathic pain can be applied from human to veterinary medicine to increase the recognition of and the ...
Rell L. Parker
doaj +1 more source
Pain-motor integration in the primary motor cortex in Parkinson's disease [PDF]
, 2017 In Parkinson's disease (PD), the influence of chronic pain on motor features has never been investigated. We have recently designed a technique that combines nociceptive system activation by laser stimuli and primary motor cortex (M1) activation through ...
Berardelli, Alfredo +9 more
core +1 more source
BMJ Open Sport & Exercise MedicineBackground Chronic pain among athletes is often misinterpreted as tissue damage resulting from sport. While researchers have started to examine neuropathic pain among athletes with spinal cord injury (SCI), there is a need to develop a deeper ...
John Kramer +3 more
doaj +1 more source
Temporal changes in the expression of the translocator protein TSPO and the steroidogenic enzyme 5a-reductase in the dorsal spinal cord of animals with neuropathic pain: effects of progesterone administration [PDF]
, 2016 Neuropathic pain is a frequent complication of spinal cord injury (SCI), still refractory to conventional treatment. The presence and biological activity of steroidogenic regulatory proteins and enzymes in the spinal cord suggests that neurosteroids ...
Adler, Natalia Sol +6 more
core +2 more sources