Oral ketamine vs placebo in patients with cancer-related neuropathic pain [PDF]
, 2018 Ketamine hydrochloride is used as an adjuvant treatment for cancer-related neuropathic pain, but evidence of its effectiveness is limited.1 Findings of a large trial investigating the use of ketamine for general cancer pain were negative, but the ...
Fallon, Marie T. +6 more
core +4 more sources
Engineering the Future of Restorative Clinical Peripheral Nerve Surgery
Advanced Healthcare Materials, EarlyView.What if damaged nerves could regenerate more effectively? This review unveils cutting‐edge strategies to restore nerve function, from biomaterial scaffolds and bioactive molecules to living engineered tissues. By accelerating axonal regrowth, preserving Schwann cells, and enhancing connectivity, these approaches are reshaping nerve repair—offering new ...
Justin C. Burrell +5 more
wiley +1 more source
Mas-related G-protein–coupled receptors inhibit pathological pain in mice [PDF]
, 2010 An important objective of pain research is to identify novel drug targets for the treatment of pathological persistent pain states, such as inflammatory and neuropathic pain.
Altier +49 more
core +2 more sources
Advanced Materials, EarlyView.This review explores the integration of responsive materials and soft robotic actuators with implantable electronics to address key challenges in bioelectronic medicine. By enabling shape actuation, these technologies improve deployment, adaptability, and accuracy in minimally invasive procedures.
Chaoqun Dong, George G. Malliaras
wiley +1 more source
Somatosensory profiles but not numbers of somatosensory abnormalities of neuropathic pain patients correspond with neuropathic pain grading. [PDF]
PLoS ONE, 2012 Due to the lack of a specific diagnostic tool for neuropathic pain, a grading system to categorize pain as 'definite', 'probable', 'possible' and 'unlikely' neuropathic was proposed.
Karl-Heinz Konopka +8 more
doaj +1 more source
Is neuropathic pain an overlooked symptom in axial spondyloarthritis?
Cukurova Medical Journal, 2022 Purpose: Axial spondyloarthritis (axSpA) is a chronic inflammatory rheumatologic disease. Pain is the most common symptom affecting quality of life in axSpA patients.
Esra Kayacan Erdoğan, İpek Türk
doaj +1 more source
Dorsal root ganglion macrophages contribute to both the initiation and persistence of neuropathic pain. [PDF]
, 2020 Paralleling the activation of dorsal horn microglia after peripheral nerve injury is a significant expansion and proliferation of macrophages around injured sensory neurons in dorsal root ganglia (DRG).
Basbaum, Allan I +8 more
core +1 more source
NGX-4010, a capsaicin 8% patch, for the treatment of painful HIV-associated distal sensory polyneuropathy: integrated analysis of two phase III, randomized, controlled trials [PDF]
, 2013 BACKGROUND HIV-associated distal sensory polyneuropathy (HIV-DSP) is the most frequently reported neurologic complication associated with HIV infection.
Brew, Bruce J +9 more
core +1 more source
Advanced Materials, EarlyView.This review highlights recent progress in piezoelectric materials for regenerative medicine, emphasizing their ability to convert mechanical stimuli into bioelectric signals that promote tissue repair. Key discussions cover the intrinsic piezoelectric properties of biological tissues, co‐stimulation cellular mechanisms for tissue regeneration, and ...
Xinyu Wang +3 more
wiley +1 more source
Evidence from web-based dietary search patterns to the role of B12 deficiency in chronic pain [PDF]
, 2017 Profound vitamin B12 deficiency is a known cause of disease, but the role of low or intermediate levels of B12 in the development of neuropathy and other neuropsychiatric symptoms as well as the relationship of eating meat and B12 levels is unclear.
arxiv +1 more source