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Structural basis of neuropeptide Y signaling through Y1 receptor [PDF]

open access: goldNature Communications, 2022
The human neuropeptide Y (NPY) acts through G-protein coupled receptors and is involved in food intake, stress response, anxiety, and memory retention.
Chaehee Park   +12 more
doaj   +2 more sources

Ligands of the neuropeptide Y Y2 receptor [PDF]

open access: greenBioorganic & Medicinal Chemistry Letters, 2013
Neuropeptide Y (NPY) is one of the most abundant neuropeptides in the mammalian brain and exerts a variety of physiological processes in humans via four different receptor subtypes Y1, Y2, Y4 and Y5. Y2 receptor is the most abundant Y subtype receptor in the central nervous system and implicated with food intake, bone formation, affective disorders ...
Gopi Kumar Mittapalli, Edward Roberts
openalex   +4 more sources

Glucose Intake during the Neonatal Period Modulates the Central Melanocortin System with Breed-Specific Differences [PDF]

open access: yesThe Journal of Poultry Science
Glucose is the primary substrate for cellular energy production, and its blood concentration is tightly regulated. This study investigated the effect of glucose supplementation during the first three days post-hatching on growth performance and ...
Kazuki Kimura   +6 more
doaj   +2 more sources

Neuropeptide Y receptors: How to get subtype selectivity [PDF]

open access: yesFrontiers in Endocrinology, 2013
The neuropeptide Y system is a multireceptor/multiligand system consisting of four receptors in humans (hY1, hY2, hY4, hY5) and three agonists (NPY, PYY, PP) that activate these receptors with different potency.
Xavier ePedragosa Badia   +2 more
doaj   +3 more sources

Targeted CRISPR approach reveals an essential role for neuropeptide Y receptor Y5 in Ewing sarcoma extrapulmonary metastasis. [PDF]

open access: greenOncogene
Adnani M   +23 more
europepmc   +3 more sources

Characterization and deorphanization of RYamide signaling in Aedes aegypti: A potential regulator of hindgut-associated physiology. [PDF]

open access: yesPLoS ONE
Neuropeptide Y-related signaling, consisting of various neuropeptides and their receptors including, for example, the mammalian neuropeptide Y (NPY), pancreatic polypeptide (PP), and peptide YY (PYY) families, along with neuropeptide Y-like peptides in ...
Jinghan Tan   +2 more
doaj   +2 more sources

Neuropeptide Y/Y5 Receptor Pathway Stimulates Neuroblastoma Cell Motility Through RhoA Activation

open access: yesFrontiers in Cell and Developmental Biology, 2021
Neuropeptide Y (NPY) has been implicated in the regulation of cellular motility under various physiological and pathological conditions, including cancer dissemination. Yet, the exact signaling pathways leading to these effects remain unknown.
Nouran Abualsaud   +9 more
doaj   +1 more source

Correlations of Gene Variants LEP rs2167270, LEPR rs1137100, GHRL rs696217, rs27647, and NPY rs16147 with Obesity and Adolescent Eating Behavior: Case-Control Study

open access: yesВопросы современной педиатрии, 2022
Background. Childhood obesity is topical global healthcare issue. The correlations between variable regions of genes encoding leptin and its receptor, ghrelin and neuropeptide Y, and the risk of obesity development in children have not been confirmed ...
Olga V. Kochetova   +4 more
doaj   +1 more source

Rabbit Annulus Fibrosus Cells Express Neuropeptide Y, Which Is Influenced by Mechanical and Inflammatory Stress [PDF]

open access: yesNeurospine, 2020
Objective Rabbit annulus fibrosus (AF) cells were exposed to isolated or combined mechanical and inflammatory stress to examine the expression of neuropeptide Y (NPY).
Malcolm E. Dombrowski   +8 more
doaj   +1 more source

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