Results 101 to 110 of about 87,108 (308)

Remote Activation of Spinal TRPV1 by Magnetic Nanocubes Confers Cardioprotection Against Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
Fe‐based magnetic nanocubes conjugated with TRPV1 antibodies (FeNCs‐TRPV1) are developed for the specific targeting of TRPV1 channels. Intraspinally injected FeNCs‐TRPV1 induces TRPV1 desensitization in rats exposed to repetitive and transient ACMF.
Xueying Cheng, Shuangyu Liu, Yu Zhang, Kang Peng, Muge Qile, Chao Wu, Mengyun Dou, Liu Liu, Na Yang, Rui Liu, Guiyang Zhang, Liangping Ni, Gaolin Liang, Fang Yang, Ye Zhang, Shufang He   +15 more
wiley   +1 more source

A Novel Integrative Mechanism in Anxiolytic Behavior Induced by Galanin 2/Neuropeptide Y Y1 Receptor Interactions on Medial Paracapsular Intercalated Amygdala in Rats

Frontiers in Cellular Neuroscience, 2018
Anxiety is evoked by a threatening situation and display adaptive or defensive behaviors, found similarly in animals and humans. Neuropeptide Y (NPY) Y1 receptor (NPYY1R) and Galanin (GAL) receptor 2 (GALR2) interact in several regions of the limbic ...
Manuel Narváez, Dasiel O. Borroto-Escuela, Dasiel O. Borroto-Escuela, Dasiel O. Borroto-Escuela, Luis Santín, Carmelo Millón, Belén Gago, Antonio Flores-Burgess, Miguel A. Barbancho, Miguel Pérez de la Mora, José Narváez, Zaida Díaz-Cabiale, Kjell Fuxe   +12 more
doaj   +1 more source

The direct response of the gonads to cues of stress in a temperate songbird species is season-dependent. [PDF]

, 2013
The gonadotropin releasing hormone (GnRH) system in the hypothalamus is often considered the final point in integration of environmental cues as they pertain to the reproductive axis.
Bentley, George, Koh, Annie, McGuire, Nicolette   +2 more
core   +2 more sources

CGRP Enhances the Regeneration of Bone Defects by Regulating Bone Marrow Mesenchymal Stem Cells Through Promoting ANGPTL4 Secretion by Bone Blood Vessels

Advanced Science, EarlyView.
ABSTRACT Bone angiogenesis is important for bone formation and regeneration after bone injury. Endothelial‐derived angiogenic factors are key signal transducers in the bone microenvironment and maintain vascular–osteogenic coupling during bone regeneration.
Qiong Lu, Qiyue Zheng, Zhaokai Zhou, Yajun Chen, Yun Chen, Wenjie Chen, Jiaojiao Wang, Ren Guo, Ren Wu, Lina Chen   +9 more
wiley   +1 more source

Research on Correlation Between Psychological Factors, Mast Cells, and PAR-2 Signal Pathway in Irritable Bowel syndrome

Journal of Inflammation Research, 2021
Guanqun Chao,1 Zhaojun Wang,2 Shuo Zhang3 1Department of General Practice, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, People’s Republic of China; 2The First Clinical Medical College of Zhejiang Chinese Medicine University, Hangzhou ...
Chao G, Wang Z, Zhang S
doaj  

Splice variants of DOMINO control Drosophila circadian behavior and pacemaker neuron maintenance. [PDF]

, 2019
Circadian clocks control daily rhythms in behavior and physiology. In Drosophila, the small ventral lateral neurons (sLNvs) expressing PIGMENT DISPERSING FACTOR (PDF) are the master pacemaker neurons generating locomotor rhythms.
Cai, Yao, Chiu, Joanna C, Lam, Vu H, Liu, Zhenxing, Mcintire, Pearson, Niu, Ye, Tabuloc, Christine A, Xue, Yongbo, Zhang, Yong   +8 more
core   +1 more source

Risk Factors for Body Weight Loss After Gastrectomy for Gastric Cancer Analyzed From the JCOG1001 Phase III Trial

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Aim To investigate the factors associated with BWL after gastrectomy using data from the phase III trial (JCOG1001). Methods This post hoc analysis included 728 patients from the JCOG1001. The percentage of BWL (%BWL) was defined as the proportion of decrease in body weight immediately before adjuvant chemotherapy initiation compared with that
Takanobu Yamada, Yukinori Kurokawa, Junki Mizusawa, Kentaro Inoue, Yasuhiro Hasegawa, Kazuhisa Ehara, Naoki Hiki, Shusaku Tsutsui, Seiji Ito, Haruhiko Fukuda, Shuji Takiguchi, Yuichiro Doki, Narikazu Boku, Takaki Yoshikawa, Masanori Terashima, Takeshi Sano, Mitsuru Sasako   +16 more
wiley   +1 more source

A Promising Therapeutic Target for Metabolic Diseases: Neuropeptide Y Receptors in Humans

Cellular Physiology and Biochemistry, 2017
Human neuropeptide Y (hNPY) is one of the most widely expressed neurotransmitters in the human central and peripheral nervous systems. It consists of 36 highly conserved amino acid residues, and was first isolated from the porcine hypothalamus in 1982 ...
Min Yi, Hekai Li, Zhiye Wu, Jianyun Yan, Qicai Liu, Caiwen Ou, Minsheng Chen   +6 more
doaj   +1 more source

Development of 'Redox Arrays' for identifying novel glutathionylated proteins in the secretome [PDF]

, 2015
Proteomics techniques for analysing the redox status of individual proteins in complex mixtures tend to identify the same proteins due to their high abundance.
Bottazzi, Barbara, Chan, Philippe, Ghezzi, Pietro, Hammouz, Raneem, Mullen, Lisa, Seavill, Miles, Vaudry, David   +6 more
core   +1 more source

Differential roles of EA‐TRAPed cells in the anterior cingulate cortex across various intervention times in inflammatory pain

Animal Models and Experimental Medicine, EarlyView.
The cumulative effect of EA analgesia is partially attributed to the activation of EA‐TRAPed cells in ACC. Multiple EA sessions and single EA sessions activated different neuronal populations in the ACC. The enhanced analgesic effect of multiple EA sessions may be attributed to an increase in the proportion of GABAergic neurons within the ACC. Abstract
Zi Guo, Ru Ye, Lu Guan, Wei He, Shuang Qiu, Xiaomei Shao, Junfan Fang, Jianqiao Fang, Junying Du   +8 more
wiley   +1 more source