Results 111 to 120 of about 87,108 (308)

Hypnotic doses of fazamorexant induced less impairment on balance and cognition than zolpidem in healthy younger and elderly individualse

British Journal of Clinical Pharmacology, EarlyView.
Aims Fazamorexant is a dual orexin receptor antagonist being developed for the treatment of insomnia. This study aims to determine the dose‐exposure‐response relationship of single‐dose fazamorexant vs. zolpidem in young adult and elderly healthy Chinese volunteers. Methods This single‐centre, randomized, double‐blind, double‐dummy, placebo‐ and active‐
Chen Xia, Huang Xingxing, Jin Lu, Wang Ruwei   +3 more
wiley   +1 more source

Recent advances in vasoactive intestinal peptide physiology and pathophysiology: focus on the gastrointestinal system. [PDF]

, 2019
Vasoactive intestinal peptide (VIP), a gut peptide hormone originally reported as a vasodilator in 1970, has multiple physiological and pathological effects on development, growth, and the control of neuronal, epithelial, and endocrine cell functions ...
Akiba, Yasutada, Iwasaki, Mari, Kaunitz, Jonathan D   +2 more
core  

Sentience in cephalopod molluscs: an updated assessment

Biological Reviews, EarlyView.
ABSTRACT This article evaluates the evidence for sentience – the capacity to have feelings – in cephalopod molluscs: octopus, cuttlefish, squid, and nautilus. Our framework includes eight criteria, covering both whether the animal's nervous system could support sentience and whether their behaviour indicates sentience.
Alexandra K. Schnell, Heather Browning, Andrew Crump, Charlotte C. Burn, Jonathan Birch   +4 more
wiley   +1 more source

Epigenetic modification of hypothalamic neuropeptides and metabolic hormone receptors in metabolic health

Frontiers in Endocrinology
The hypothalamus plays a central role in regulating metabolism by integrating neuropeptide signaling with environmental cues to maintain energy homeostasis.
Busayo Oladun, Smita Mall, Min-Hyun Kim
doaj   +1 more source

Neuropeptide Y receptor Y2 (npy2r) deficiency reduces anxiety and increases food intake in Japanese medaka (Oryzias latipes). [PDF]

Front Cell Dev Biol, 2023
Lu K, Jia X, Wu J, Wang Q, Liang XF.
europepmc   +1 more source

Fetal Pain Perception: Legislative Assertions and Developmental Neuroscience

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Background Pain perception is a conscious experience, but neither pain nor consciousness is defined in the developing human fetus. Emergent consciousness may be regarded as a phenomenon that ultimately arises from an essential minimum of functional neuronal connectivity. Proposed U.S.
William D. Graf, Timothy M. Crombleholme, Leon G. Epstein, Dawn Gano, Phillip L. Pearl, Timothy V. Salomons, Mark S. Scher, Elise Turk, Klaus‐Peter Zimmer, Harvey B. Sarnat   +9 more
wiley   +1 more source

Characterisation of Neuropeptide Y Receptor Subtypes by Synthetic NPY Analogues and by Anti-receptor Antibodies

Molecules, 2001
Neuropeptide Y (NPY), a 36-mer neuromodulator, binds to the receptors Y1, Y2, Y4 and Y5 with nanomolar affinity. They all belong to the rhodopsin-like G-protein coupled, seven transmembrane helix spanning receptors.
Annette G. Beck-Sickinger, Heike A. Wieland, Chiara Cabrele, Christophe P. Eckard   +3 more
doaj   +1 more source

Oxytocin Effects on Food Stimulus Processing and Food Intake in Females With or Without Binge Eating Disorder

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Binge eating disorder (BED) is maintained by increased food‐related incentive salience, which is reflected by an attentional bias for food. Oxytocin acutely attenuates this bias in patients with anorexia nervosa and reduces food intake in males with normal or increased body weight.
Julia Nannt, Mechteld M. van den Hoek Ostende, Brunna Tuschen‐Caffier, Markus Heinrichs, Daniel Sippel, Manfred Hallschmid, Jennifer Svaldi   +6 more
wiley   +1 more source

Gut‐microbiota‐brain Axis and post‐traumatic epilepsy

Epilepsia Open, EarlyView.
Abstract There has been growing evidence that perturbations in gut‐microbiota‐brain axis (GMBA) are involved in mechanisms of chronic sequelae of traumatic brain injury (TBI). This review discusses the connection between GMBA and post‐traumatic epilepsy (PTE), the latter being a common outcome of TBI.
Andrey Mazarati
wiley   +1 more source

Neuropeptide Y neurons mediate opioid-induced itch by disinhibiting GRP-GRPR microcircuits in the spinal cord

Nature Communications
Itch is a common side effect of opioid analgesics. The specific neurons mediating opioid-induced itch are still debated, and the mechanistic neuronal circuits remain elusive.
Qian Zeng, Yitong Li, Yifei Wu, Jiawei Wu, Kangtai Xu, Yiming Chen, Yunfei Rao, Nan Li, Yuhui Luo, Changyu Jiang, Chaoran Wu, Zilong Wang   +11 more
doaj   +1 more source