Fine-Tuning of the Neuropeptide Y1 G Protein-Coupled Receptor by the Tryptophan<sup>6.48</sup> "Toggle Switch". [PDF]
Voitel M +7 more
europepmc +1 more source
Cardiac Sympathetic Innervation and Ventricular Arrhythmias in Structural Heart Disease: Current Peripheral Neuromodulation Therapies and Emerging Therapeutic Targets. [PDF]
Benabou L, Vaseghi M.
europepmc +1 more source
Effect of Centrally Administered Neuropeptide Y and α-Melanocyte-stimulating Hormone on Water Intake in Chicks. [PDF]
Dialoke NG +7 more
europepmc +1 more source
Neuropeptide Y and its receptor analogs modulate ischemia-induced nitric oxide production
S-H Chen, Rtf Cheung
openalex +1 more source
Vasoactive neuropeptide dysregulation: A novel mechanism of microvascular dysfunction in vascular cognitive impairment. [PDF]
Tambo W +9 more
europepmc +1 more source
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Neuropeptide Y receptor subtypes
Life Sciences, 1995Neuropeptide Y (NPY) is an amidated 36-amino acid peptide with a wide distribution in the central and peripheral nervous system. It can evoke numerous physiological responses by activating specific receptors. Studies using NPY analogs in various model systems and cell types demonstrate different orders of ligand potency and receptor binding affinity ...
C P, Wan, B H, Lau
openaire +2 more sources
Dihydropyridine Neuropeptide Y Y1 Receptor Antagonists
Bioorganic & Medicinal Chemistry Letters, 2002Dihydropyridine 5a was found to be an inhibitor of neuropeptide Y(1) binding in a high throughput (125)I-PYY screening assay. Structure-activity studies around certain portions of the dihydropyridine chemotype identified BMS-193885 (6e) as a potent and selective Y(1) receptor antagonist.
Graham S, Poindexter +13 more
openaire +2 more sources
Neuropeptide Y receptor antagonists in obesity
Expert Opinion on Investigational Drugs, 1997Neuropeptide Y (NPY) is a 36 amino acid amidated peptide with high sequence homology to the endocrine peptides, peptide YY (PYY) and pancreatic polypeptide (PP). They appear to interact with a family of receptors that possess high affinity for one or more of these peptides.
D R, Gehlert, P A, Hipskind
openaire +2 more sources

