Results 11 to 20 of about 47,789 (213)

The effect of human wharton’s jelly-derived mesenchymal stem cells on MC4R, NPY, and LEPR gene expression levels in rats with streptozotocin-induced diabetes [PDF]

Iranian Journal of Basic Medical Sciences, 2020
Objective(s): Type 1 diabetes (T1D) is an autoimmune disease resulting from inflammatory destruction of islets β-cells. Nowadays, progress in cell therapy, especially mesenchymal stem cells (MSCs) proposes numerous potential remedies for T1D. We aimed to
Fatemeh Sabet Sarvestani, Mohammad Ali Zare, Forough saki, Farhad Koohpeyma, Ismail H. al-Abdullah, Negar Azarpira   +5 more
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Identification of neuropeptides and neuropeptide receptor genes in Phauda flammans (Walker)

Scientific Reports, 2022
Neuropeptides and neuropeptide receptors are crucial regulators to insect physiological processes. The 21.0 Gb bases were obtained from Illumina sequencing of two libraries representing the female and male heads of Phauda flammans (Walker) (Lepidoptera ...
Hai-Pan Wu, Xiao-Yun Wang, Jin Hu, Ran-Ran Su, Wen Lu, Xia-Lin Zheng   +5 more
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Lateral hypothalamic leptin receptor neurons drive hunger-gated food-seeking and consummatory behaviours in male mice

Nature Communications, 2023
Eating behviours consist of seeking and consummatory phases. Here, authors show that two distinct lateral hypothalamic leptin receptor neurons orchestrate seeking and consummatory phases of eating behaviour via hunger signal, Neuropeptide Y.
Young Hee Lee, Yu-Been Kim, Kyu Sik Kim, Mirae Jang, Ha Young Song, Sang-Ho Jung, Dong-Soo Ha, Joon Seok Park, Jaegeon Lee, Kyung Min Kim, Deok-Hyeon Cheon, Inhyeok Baek, Min-Gi Shin, Eun Jeong Lee, Sang Jeong Kim, Hyung Jin Choi   +15 more
doaj   +1 more source

Role of Zip1 in the regulation of NPY expression by MLT to promote fracture healing in rats

European Journal of Histochemistry, 2020
Our previous study documented that melatonin (MLT) induced the osteogenic differentiation of mesenchymal stem cells (MSCs) and promoted the healing of femoral fractures in rats via the neuropeptide Y (NPY)/neuropeptide Y1 receptor (NPY1R) signaling ...
Junjun Shang, Bin Ma, Guiling Zhu, Penghong Dong, Chan Wang, Xiaochuan Gu, Ying Zi   +6 more
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Structural basis for ligand recognition of the neuropeptide Y Y2 receptor

Nature Communications, 2021
The human neuropeptide Y receptor Y2 (Y2R) is a drug target for the treatment of obesity and anxiety. Crystal structure of Y2R bound to a selective antagonist and accompanying mutagenesis provide insights into ligand recognition and subtype specificity ...
Tingting Tang, Christin Hartig, Qiuru Chen, Wenli Zhao, Anette Kaiser, Xuefeng Zhang, Hui Zhang, Honge Qu, Cuiying Yi, Limin Ma, Shuo Han, Qiang Zhao, Annette G. Beck-Sickinger, Beili Wu   +13 more
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Intranasal Delivery of Galanin 2 and Neuropeptide Y1 Agonists Enhanced Spatial Memory Performance and Neuronal Precursor Cells Proliferation in the Dorsal Hippocampus in Rats

Frontiers in Pharmacology, 2022
A need for new therapeutic approaches are necessary for dementia conditions and memory deficits of different origins, such as Alzheimer's disease. There is complex pathophysiological mechanisms involved, affecting adult hippocampal neurogenesis, in which
Dasiel O. Borroto-Escuela, Dasiel O. Borroto-Escuela, Dasiel O. Borroto-Escuela, Ramón Fores, Ramón Fores, Mariana Pita, Mariana Pita, Mariana Pita, Miguel A. Barbancho, Pablo Zamorano‐Gonzalez, Natalia García Casares, Kjell Fuxe, Manuel Narváez, Manuel Narváez   +13 more
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Combined gene overexpression of neuropeptide Y and its receptor Y5 in the hippocampus suppresses seizures

Neurobiology of Disease, 2012
We recently demonstrated that recombinant adeno-associated viral vector-induced hippocampal overexpression of neuropeptide Y receptor, Y2, exerts a seizure-suppressant effect in kindling and kainate-induced models of epilepsy in rats.
Casper R. Gøtzsche, Litsa Nikitidou, Andreas T. Sørensen, Mikkel V. Olesen, Gunnar Sørensen, Søren H.O. Christiansen, Mikael Ängehagen, David P.D. Woldbye, Merab Kokaia   +8 more
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Towards Probing Conformational States of Y2 Receptor Using Hyperpolarized ¹²⁹Xe NMR

Molecules, 2023
G protein-coupled receptors can adopt many different conformational states, each of them exhibiting different restraints towards downstream signaling pathways.
Peter Schmidt, Alexander Vogel, Benedikt Schwarze, Florian Seufert, Kai Licha, Virginia Wycisk, Wolfgang Kilian, Peter W. Hildebrand, Lorenz Mitschang   +8 more
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Characterization of vascular neuropeptide Y receptors [PDF]

British Journal of Pharmacology, 1992
In the present study we compared neuropeptide Y (NPY) and NPY‐related analogues for their ability to activate or bind to vascular NPY receptors in four experimental set‐ups. Previous results have suggested the existence of different receptor subtypes, Y1 receptors requiring full‐length NPY (1–36) or [Pro34]‐NPY, and Y2 receptors recognizing also N ...
L, Grundemar, S E, Jonas, N, Mörner, E D, Högestätt, C, Wahlestedt, R, Håkanson   +5 more
openaire   +2 more sources

Antisense mRNA for NPY-Y1 receptor in the medial preoptic area increases prolactin secretion

Brazilian Journal of Medical and Biological Research, 1999
We investigated the participation of neuropeptide Y-Y1 receptors within the medial preoptic area in luteinizing hormone, follicle-stimulating hormone and prolactin release.
N.A. Silveira, C.R. Franci
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