Neuropeptide Y receptors: How to get subtype selectivity [PDF]
Frontiers in Endocrinology, 2013 The neuropeptide Y system is a multireceptor/multiligand system consisting of four receptors in humans (hY1, hY2, hY4, hY5) and three agonists (NPY, PYY, PP) that activate these receptors with different potency.
Xavier ePedragosa Badia +2 more
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Neuropeptide Y/Y5 Receptor Pathway Stimulates Neuroblastoma Cell Motility Through RhoA Activation
Frontiers in Cell and Developmental Biology, 2021 Neuropeptide Y (NPY) has been implicated in the regulation of cellular motility under various physiological and pathological conditions, including cancer dissemination. Yet, the exact signaling pathways leading to these effects remain unknown.
Nouran Abualsaud +9 more
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Вопросы современной педиатрии, 2022 Background. Childhood obesity is topical global healthcare issue. The correlations between variable regions of genes encoding leptin and its receptor, ghrelin and neuropeptide Y, and the risk of obesity development in children have not been confirmed ...
Olga V. Kochetova +4 more
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Differential Changes in Expression of Stress- and Metabolic-related Neuropeptides in the Rat Hypothalamus during Morphine Dependence and Withdrawal [PDF]
, 2013 Chronic morphine treatment and naloxone precipitated morphine withdrawal activates stress-related brain circuit and results in significant changes in food intake, body weight gain and energy metabolism.
Ferenczi, Szilamér +6 more
core +8 more sources
Rabbit Annulus Fibrosus Cells Express Neuropeptide Y, Which Is Influenced by Mechanical and Inflammatory Stress [PDF]
Neurospine, 2020 Objective Rabbit annulus fibrosus (AF) cells were exposed to isolated or combined mechanical and inflammatory stress to examine the expression of neuropeptide Y (NPY).
Malcolm E. Dombrowski +8 more
doaj +1 more source
The effect of human wharton’s jelly-derived mesenchymal stem cells on MC4R, NPY, and LEPR gene expression levels in rats with streptozotocin-induced diabetes [PDF]
Iranian Journal of Basic Medical Sciences, 2020 Objective(s): Type 1 diabetes (T1D) is an autoimmune disease resulting from inflammatory destruction of islets β-cells. Nowadays, progress in cell therapy, especially mesenchymal stem cells (MSCs) proposes numerous potential remedies for T1D. We aimed to
Fatemeh Sabet Sarvestani +5 more
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Identification of neuropeptides and neuropeptide receptor genes in Phauda flammans (Walker)
Scientific Reports, 2022 Neuropeptides and neuropeptide receptors are crucial regulators to insect physiological processes. The 21.0 Gb bases were obtained from Illumina sequencing of two libraries representing the female and male heads of Phauda flammans (Walker) (Lepidoptera ...
Hai-Pan Wu +5 more
doaj +1 more source
Nature Communications, 2023 Eating behviours consist of seeking and consummatory phases. Here, authors show that two distinct lateral hypothalamic leptin receptor neurons orchestrate seeking and consummatory phases of eating behaviour via hunger signal, Neuropeptide Y.
Young Hee Lee +15 more
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Role of Zip1 in the regulation of NPY expression by MLT to promote fracture healing in rats
European Journal of Histochemistry, 2020 Our previous study documented that melatonin (MLT) induced the osteogenic differentiation of mesenchymal stem cells (MSCs) and promoted the healing of femoral fractures in rats via the neuropeptide Y (NPY)/neuropeptide Y1 receptor (NPY1R) signaling ...
Junjun Shang +6 more
doaj +1 more source
Structural basis for ligand recognition of the neuropeptide Y Y2 receptor
Nature Communications, 2021 The human neuropeptide Y receptor Y2 (Y2R) is a drug target for the treatment of obesity and anxiety. Crystal structure of Y2R bound to a selective antagonist and accompanying mutagenesis provide insights into ligand recognition and subtype specificity ...
Tingting Tang +13 more
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