Results 31 to 40 of about 47,789 (213)

New antagonist agents of neuropeptide y receptors [PDF]

Química Nova, 2000
0 ...
Aldana, Ignacio, Rivero, Isabel, Rivero, Argimiro, Huenchuñir, Patricio, Frigola, Carmen, Alonso, Maria Luisa, Monge, Antonio, Caignard, D. H., Renard, P.   +8 more
openaire   +5 more sources

Neuropeptide Y receptor in the rat brain [PDF]

European Journal of Biochemistry, 1984
The specific binding of the chloramine-T iodinated neuropeptide Y (125I-NPY) to membranes from rat cerebral cortex was investigated using equilibrium binding and kinetic methods. The equilibrium binding of 125I-NPY at 37 degrees C was characterized by a Kd value of 0.38 nM. The receptor densities in the cerebral cortex, hypothalamus and cerebellum were
A, Undén, K, Tatemoto, V, Mutt, T, Bartfai   +3 more
openaire   +2 more sources

Neuropeptides and pharmacology [PDF]

Proceedings of the Estonian Academy of Sciences
The aim of the article is to briefly describe our work together with Dr. Viktor Mutt. He discovered and purified many new gastrointestinal bioactive neuropeptides that have important applications as therapeutic agents in diabetes, epilepsy, migraine and ...
Tamas Bartfai, Pēteris Alberts
doaj   +1 more source

Spinal Neuropeptide Y1 Receptor-Expressing Neurons Form an Essential Excitatory Pathway for Mechanical Itch

Cell Reports, 2019
Summary: Acute itch can be generated by either chemical or mechanical stimuli, which activate separate pathways in the periphery and spinal cord. While substantial progress has been made in mapping the transmission pathway for chemical itch, the central ...
David Acton, Xiangyu Ren, Stefania Di Costanzo, Antoine Dalet, Steeve Bourane, Ilaria Bertocchi, Carola Eva, Martyn Goulding   +7 more
doaj   +1 more source

Structural basis of neuropeptide Y signaling through Y1 and Y2 receptors

MedComm
Neuropeptide Y (NPY), a 36‐amino‐acid peptide, functions as a neurotransmitter in both the central and peripheral nervous systems by activating the NPY receptor subfamily.
Siyuan Shen, Yue Deng, Chenglong Shen, Haidi Chen, Lin Cheng, Chao Wu, Chang Zhao, Zhiqian Yang, Hanlin Hou, Kexin Wang, Zhenhua Shao, Cheng Deng, Feng Ye, Wei Yan   +13 more
doaj   +1 more source

Off-label and investigational drugs in the treatment of alcohol use disorder: A critical review

Frontiers in Pharmacology, 2022
Compounds known to be successful in the treatment of alcohol use disorder include the aversive agent, Disulfiram, the glutamatergic NMDA receptor antagonist, Acamprosate, and the opioid receptor antagonists, Naltrexone and Nalmefene.
Pascal Valentin Fischler, Michael Soyka, Erich Seifritz, Jochen Mutschler   +3 more
doaj   +1 more source

PET Imaging of the Neuropeptide Y System: A Systematic Review

Molecules, 2022
Neuropeptide Y (NPY) is a vastly studied biological peptide with numerous physiological functions that activate the NPY receptor family (Y1, Y2, Y4 and Y5).
Inês C. F. Fonseca, Miguel Castelo-Branco, Cláudia Cavadas, Antero J. Abrunhosa   +3 more
doaj   +1 more source

Y₁ and Y₂ receptors for neuropeptide Y [PDF]

FEBS Letters, 1989
By using monoiodinated radioligands of both intact neuropeptide Y (NPY) and of a long C‐terminal fragment, NPY13–36, two subtypes of binding sites, which differ in affinity and specificity, have been characterized. The Y1 type of binding site, characterized on a human neuroblastoma cell line, MC‐IXC, and a rat pheochromocytoma cell line, PC‐12, binds ...
Sheikh, Søren P., Håkanson, Rolf, Schwartz, Thue W.   +2 more
openaire   +2 more sources

Pharmacological and functional similarities of the human neuropeptide Y system in C. elegans challenges phylogenetic views on the FLP/NPR system

Cell Communication and Signaling, 2019
Background The neuropeptide Y system affects various processes, among others food intake, and is frequently discussed in the context of targeting obesity. Studies in model organisms are indispensable to enable molecular studies in a physiological context.
Miron Mikhailowitsch Gershkovich, Victoria Elisabeth Groß, Anette Kaiser, Simone Prömel   +3 more
doaj   +1 more source

Elevated Neuropeptide Y in Endothelial Dysfunction Promotes Macrophage Infiltration and Smooth Muscle Foam Cell Formation

Frontiers in Immunology, 2019
Endothelial dysfunction has been linked to vascular inflammation and foam cell formation but the underlying mechanisms still remain unclear. We sought to define the factors inducing inflammation and smooth muscle foam cell formation under endothelial ...
Bongkun Choi, Bongkun Choi, Min-Kyung Shin, Min-Kyung Shin, Eun-Young Kim, Eun-Young Kim, Ji-Eun Park, Ji-Eun Park, Halim Lee, Seong Who Kim, Seong Who Kim, Jae-Kwan Song, Eun-Ju Chang, Eun-Ju Chang, Eun-Ju Chang   +14 more
doaj   +1 more source