Results 31 to 40 of about 213,878 (394)

Synthesis of receptor antagonists of neuropeptide Y. [PDF]

Proceedings of the National Academy of Sciences, 1992
We report the synthesis of receptor antagonists of neuropeptide Y (NPY) by a strategy based on synthesis of mixtures of analogs and the subsequent isolation and identification of receptor antagonists from these mixtures. After screening a series of mixtures of NPY analogs by using an NPY antagonist assay, two potent receptor antagonists, designated PYX-
Meikyo Shimizu, Kazuhiko Tatemoto, Michael J. Mann   +2 more
openaire   +3 more sources

Role of Zip1 in the regulation of NPY expression by MLT to promote fracture healing in rats

European Journal of Histochemistry, 2020
Our previous study documented that melatonin (MLT) induced the osteogenic differentiation of mesenchymal stem cells (MSCs) and promoted the healing of femoral fractures in rats via the neuropeptide Y (NPY)/neuropeptide Y1 receptor (NPY1R) signaling ...
Junjun Shang, Bin Ma, Guiling Zhu, Penghong Dong, Chan Wang, Xiaochuan Gu, Ying Zi   +6 more
doaj   +1 more source

Structural basis for ligand recognition of the neuropeptide Y Y2 receptor

Nature Communications, 2021
The human neuropeptide Y receptor Y2 (Y2R) is a drug target for the treatment of obesity and anxiety. Crystal structure of Y2R bound to a selective antagonist and accompanying mutagenesis provide insights into ligand recognition and subtype specificity ...
Tingting Tang, Christin Hartig, Qiuru Chen, Wenli Zhao, Anette Kaiser, Xuefeng Zhang, Hui Zhang, Honge Qu, Cuiying Yi, Limin Ma, Shuo Han, Qiang Zhao, Annette G. Beck-Sickinger, Beili Wu   +13 more
doaj   +1 more source

Intranasal Delivery of Galanin 2 and Neuropeptide Y1 Agonists Enhanced Spatial Memory Performance and Neuronal Precursor Cells Proliferation in the Dorsal Hippocampus in Rats

Frontiers in Pharmacology, 2022
A need for new therapeutic approaches are necessary for dementia conditions and memory deficits of different origins, such as Alzheimer's disease. There is complex pathophysiological mechanisms involved, affecting adult hippocampal neurogenesis, in which
Dasiel O. Borroto-Escuela, Dasiel O. Borroto-Escuela, Dasiel O. Borroto-Escuela, Ramón Fores, Ramón Fores, Mariana Pita, Mariana Pita, Mariana Pita, Miguel A. Barbancho, Pablo Zamorano‐Gonzalez, Natalia García Casares, Kjell Fuxe, Manuel Narváez, Manuel Narváez   +13 more
doaj   +1 more source

NPY1R (neuropeptide Y receptor Y1) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on NPY1R (neuropeptide Y receptor Y1), with data on DNA, on the protein encoded, and where the gene is implicated.
M. Ruscica, E. Dozio, L. Passafaro, P. Magni   +3 more
openaire   +4 more sources

DINeR: Database for Insect Neuropeptide Research [PDF]

, 2017
Neuropeptides are responsible for regulating a variety of functions, including development, metabolism, water and ion homeostasis, and as neuromodulators in circuits of the central nervous system.
Davies, Shireen-Anne, Dow, Julian, Nässel, Dick R., Pandit, Aniruddha A., Yeoh, Joseph G.C., Zandawala, Meet   +5 more
core   +1 more source

Platelet lysate-derived neuropeptide y influences migration and angiogenesis of human adipose tissue-derived stromal cells [PDF]

, 2018
Neuropeptide Y (NPY), a powerful neurotransmitter of the central nervous system, is a key regulator of angiogenesis and biology of adipose depots. Intriguingly, its peripheral vascular and angiogenic powerful activity is strictly associated to platelets,
Bordin, Antonella, Businaro, Rita, Capoano, Raffaele, Corsi, Mariangela, DE FALCO, Elena, Frati, Giacomo, Pagano, Francesca, Petrozza, Vincenzo, Pierangelatotta,, Procaccini, Eugenio, Salvati, Bruno, Scaccia, Eleonora, Siciliano, Camilla, Teresa Vietri, Maria   +13 more
core   +2 more sources

Y₁ and Y₂ receptors for neuropeptide Y [PDF]

FEBS Letters, 1989
By using monoiodinated radioligands of both intact neuropeptide Y (NPY) and of a long C‐terminal fragment, NPY13–36, two subtypes of binding sites, which differ in affinity and specificity, have been characterized. The Y1 type of binding site, characterized on a human neuroblastoma cell line, MC‐IXC, and a rat pheochromocytoma cell line, PC‐12, binds ...
Thue W. Schwartz, Rolf Håkanson, Søren P. Sheikh   +2 more
openaire   +3 more sources

Structural basis of neuropeptide Y signaling through Y1 receptor

Nature Communications, 2022
The human neuropeptide Y (NPY) acts through G-protein coupled receptors and is involved in food intake, stress response, anxiety, and memory retention.
Chaehee Park, Jinuk Kim, Seung-Bum Ko, Yeol Kyo Choi, Hyeongseop Jeong, Hyeonuk Woo, Hyunook Kang, Injin Bang, Sang Ah Kim, Tae-Young Yoon, Chaok Seok, Wonpil Im, Hee-Jung Choi   +12 more
doaj   +1 more source

Coordinated RNA-Seq and peptidomics identify neuropeptides and G-protein coupled receptors (GPCRs) in the large pine weevil Hylobius abietis, a major forestry pest [PDF]

, 2018
Hylobius abietis (Linnaeus), or large pine weevil (Coleoptera, Curculionidae), is a pest of European coniferous forests. In order to gain understanding of the functional physiology of this species, we have assembled a de novo transcriptome of H. abietis,
Davies, Shireen-Anne, Dow, Julian A.T., Inward, Daegan J.G., Marley, Richard, Pandit, Aniruddha A., Predel, Reinhard, Ragionieri, Lapo, Yeoh, Joseph G.C.   +7 more
core   +1 more source