Results 41 to 50 of about 47,789 (213)

Effects of Nifedipine on Renal and Cardiovascular Responses to Neuropeptide Y in Anesthetized Rats

Molecules, 2021
Neuropeptide Y (NPY) acts via multiple receptor subtypes termed Y1, Y2 and Y5. While Y1 receptor-mediated effects, e.g., in the vasculature, are often sensitive to inhibitors of L-type Ca2+ channels such as nifedipine, little is known about the role of ...
Angela Bischoff, Martina Stickan-Verfürth, Martin C. Michel   +2 more
doaj   +1 more source

High-affinity neuropeptide Y receptor antagonists. [PDF]

Proceedings of the National Academy of Sciences, 1995
Neuropeptide Y (NPY) is one of the most abundant peptide transmitters in the mammalian brain. In the periphery it is costored and coreleased with norepinephrine from sympathetic nerve terminals. However, the physiological functions of this peptide remain unclear because of the absence of specific high-affinity receptor antagonists.
A J, Daniels, J E, Matthews, R J, Slepetis, M, Jansen, O H, Viveros, A, Tadepalli, W, Harrington, D, Heyer, A, Landavazo, J J, Leban, A, Spaltenstein   +10 more
openaire   +2 more sources

Peripherally Administered Y2-Receptor Antagonist BIIE0246 Prevents Diet-Induced Obesity in Mice With Excess Neuropeptide Y, but Enhances Obesity in Control Mice

Frontiers in Pharmacology, 2018
Neuropeptide Y (NPY) plays an important role in the regulation of energy homeostasis in the level of central and sympathetic nervous systems (SNSs).
Liisa Ailanen, Liisa Ailanen, Laura H. Vähätalo, Henriikka Salomäki-Myftari, Henriikka Salomäki-Myftari, Satu Mäkelä, Wendy Orpana, Suvi T. Ruohonen, Eriika Savontaus, Eriika Savontaus   +9 more
doaj   +1 more source

Central Administration of BIBP3226, Neuropeptide Y (NPY) Y1 Receptor Antagonist, does not Inhibit Fasting- and NPY-Induced Food Intake in Neonatal Chicks

The Journal of Poultry Science, 2001
Neuropeptide Y (NPY) is known to be an essential orexigenic signal in mammalian and avian brain. Since NPY receptors in the avian brain have not been clarified, to determine whether Y1 receptor or Y1-like receptor(s) mediates the orexigenic effect of NPY
Shin-ichi Kawakami, Ryuichi Ando, Takashi Bungo, Atsushi Ohgushi, Tetsuya Tachibana, D. Michael Denbow, Mitsuhiro Furuse   +6 more
doaj   +1 more source

Evidence for epigenetic alterations in PTSD

European Journal of Psychotraumatology, 2012
Rationale/statement of the problem : Neuropeptide Y (NPY) is a peptide with behaviorally relevant effects on the hippocampus and is thought to function as an endogenous anxiolytic.
Janine D. Flory, Linda M. Bierer, Frank Desarnaud, Iouri Makotkine, Ashik Siddique, Charles Marmar, Rachel Yehuda   +6 more
doaj   +1 more source

Next-generation neuropeptide Y receptor small-molecule agonists inhibit mosquito-biting behavior

Parasites & Vectors
Background Female Aedes aegypti mosquitoes can spread disease-causing pathogens when they bite humans to obtain blood nutrients required for egg production. Following a complete blood meal, host-seeking is suppressed until eggs are laid.
Emely V. Zeledon, Leigh A. Baxt, Tanweer A. Khan, Mayako Michino, Michael Miller, David J. Huggins, Caroline S. Jiang, Leslie B. Vosshall, Laura B. Duvall   +8 more
doaj   +1 more source

Neuropeptide Y is important for basal and seizure-induced precursor cell proliferation in the hippocampus

Neurobiology of Disease, 2007
We have shown that neuropeptide Y (NPY) regulates neurogenesis in the normal dentate gyrus (DG) via Y1 receptors (Howell, O.W., Scharfman, H.E., Herzog, H., Sundstrom, L.E., Beck-Sickinger, A. and Gray, W.P.
Owain W. Howell, Sharmalene Silva, Helen E. Scharfman, Alexander A. Sosunov, Malik Zaben, Anan Shatya, Guy Mckhann, II, Herbert Herzog, Alexandra Laskowski, William P. Gray   +9 more
doaj   +1 more source

Neuropeptide F regulates courtship in Drosophila through a male-specific neuronal circuit

eLife, 2019
Male courtship is provoked by perception of a potential mate. In addition, the likelihood and intensity of courtship are influenced by recent mating experience, which affects sexual drive.
Weiwei Liu, Anindya Ganguly, Jia Huang, Yijin Wang, Jinfei D Ni, Adishthi S Gurav, Morris A Aguilar, Craig Montell   +7 more
doaj   +1 more source

Human neuropeptide Y Y1 receptor antisense oligodeoxynucleotide specifically inhibits neuropeptide Y-evoked vasoconstriction

European Journal of Pharmacology, 1993
This paper describes a new approach for the development of an inhibitor of the contractile responses of neuropeptide Y in human blood vessels by the use of an antisense oligodeoxynucleotide complementary to human neuropeptide Y Y1 receptor mRNA. One micromolar of an antisense 18-base oligodeoxynucleotide (hY1-AS), corresponding to the human Y1 receptor
D, Erlinge, L, Edvinsson, J, Brunkwall, F, Yee, C, Wahlestedt   +4 more
openaire   +2 more sources

Molecular mechanism of prolactin-releasing peptide recognition and signaling via its G protein-coupled receptor

Cell Discovery
Prolactin-releasing peptide (PrRP) is an RF-amide neuropeptide that binds and activates its cognate G protein-coupled receptor, prolactin-releasing peptide receptor (PrRPR), also known as GPR10.
Yang Li, Qingning Yuan, Xinheng He, Yumu Zhang, Chongzhao You, Canrong Wu, Jingru Li, H. Eric Xu, Li-Hua Zhao   +8 more
doaj   +1 more source