Results 61 to 70 of about 47,789 (213)

Downregulation of the NPY-Y1R system in Grpr neurons results in mechanical and chemical hyperknesis in chronic itch

open access: yesNeurobiology of Disease
Chronic itch remains a clinically challenging condition with limited therapeutic efficacy, posing a significant burden on patients' quality of life. Despite its prevalence, the underlying neural mechanisms remain poorly understood.
Danqing Dai   +7 more
doaj   +1 more source

Research progress of gene target therapy for refractory epilepsy

open access: yesChinese Journal of Contemporary Neurology and Neurosurgery, 2014
Nowadays, the strategies of gene therapy for the treatment of refractory epilepsy (RE) mainly include modulating neurotransmitter systems, neuropeptide Y (NPY) and neurotrophic factors.
Xing-hua TANG, Lin LI, Zhen-guo LIU
doaj  

The Dynamics of the Neuropeptide Y Receptor Type 1 Investigated by Solid-State NMR and Molecular Dynamics Simulation. [PDF]

open access: yesMolecules, 2020
Vogel A   +9 more
europepmc   +1 more source

Structural basis for recognition of 26RFa by the pyroglutamylated RFamide peptide receptor

open access: yesCell Discovery
The neuropeptide 26RFa, a member of the RF-amide peptide family, activates the pyroglutamylated RF-amide peptide receptor (QRFPR), a class A GPCR. The 26RFa/QRFPR system plays critical roles in energy homeostasis, making QRFPR an attractive drug target ...
Sanshan Jin   +16 more
doaj   +1 more source

Defining structural requirements for neuropeptide Y receptors using truncated and conformationally restricted analogs

open access: green, 1993
Dean A. Kirby   +6 more
openalex   +1 more source

Structure–activity relationships of neuropeptide Y Y1 receptor antagonists related to BIBP 3226

open access: green, 2000
Iris Aiglstorfer   +5 more
openalex   +1 more source

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