Results 61 to 70 of about 213,878 (394)

Neuropeptides and pharmacology [PDF]

Proceedings of the Estonian Academy of Sciences
The aim of the article is to briefly describe our work together with Dr. Viktor Mutt. He discovered and purified many new gastrointestinal bioactive neuropeptides that have important applications as therapeutic agents in diabetes, epilepsy, migraine and ...
Tamas Bartfai, Pēteris Alberts
doaj   +1 more source

Structural analysis of the starfish SALMFamide neuropeptides S1 and S2: The N-terminal region of S2 facilitates self-association [PDF]

, 2014
The neuropeptides S1 (GFNSALMFamide) and S2 (SGPYSFNSGLTFamide), which share sequence similarity, were discovered in the starfish Asterias rubens and are prototypical members of the SALMFamide family of neuropeptides in echinoderms.
Bader, Cavanagh, Chassaing, Christopher E. Jones, Cierpicki, Claire B. Otara, Cowsik, Edison, Elphick, Elphick, Elphick, Elphick, Elphick, Feeney, Fontenot, Grace, Grace, Greenfield, Inooka, John H. Viles, Keire, Ma, Maurice R. Elphick, Melarange, Melarange, Nadine D. Younan, Newman, Newman, Nieto, Rowe, Sumner, Wuthrich, Xu   +32 more
core   +1 more source

Semaphorin 3E‐Plexin‐D1 Pathway Downstream of the Luteinizing Hormone Surge Regulates Ovulation, Granulosa Cell Luteinization, and Ovarian Angiogenesis in Mice

Advanced Science, EarlyView.
The Semaphorin 3E (Sema3E)‐Plexin‐D1 pathway mediated by C/EBPα and C/EBPβ downstream of the luteinizing hormone (LH) surge plays important roles in the mouse preovulatory ovary. Timely activation and suppression of this pathway during the preovulatory stage are crucial for ovulation, corpus luteum formation, and proper angiogenesis.
Hanxue Zhang, Jimmy Dhillon, Paul D. Soloway, Bo Shui, Seoyeon Lee, Jennifer K. Grenier, Paul R. Munn, M. Cecilia Ljungberg, Rebecca B Williams, Rainer B. Lanz, Yu‐Hsiang Liao, Yi A. Ren   +11 more
wiley   +1 more source

Phylogenomic analysis reveals extensive phylogenetic mosaicism in the Human GPCR Superfamily [PDF]

, 2007
A novel high throughput phylogenomic analysis (HTP) was applied to the rhodopsin G-protein coupled receptor (GPCR) family. Instances of phylogenetic mosaicism between receptors were found to be frequent, often as instances of correlated mosaicism and ...
Allaby, Robin G., Woodwark, Mathew
core   +2 more sources

Molecular Genetic Analysis of a Human Neuropeptide Y Receptor

Journal of Biological Chemistry, 1997
Neuropeptide Y is a 36-amino-acid peptide amide with numerous biological activities. These functions are mediated through several pharmacologically distinct receptors. To date five receptor subtypes have been cloned.
P. M. Rose, J. Lynch, S. Frazier, S. Fisher, Wendy Chung, Peter B Battaglino, Z. Fathi, R. Leibel, P. Fernandes   +8 more
semanticscholar   +1 more source

Inhibition of Phosphodiesterase 10A by MP‐10 Rescues Behavioral Deficits and Normalizes Microglial Morphology and Synaptic Pruning in A Mouse Model of FOXP1 Syndrome

Advanced Science, EarlyView.
We demonstrate that Foxp1± mice, modeling FOXP1 haploinsufficiency, exhibit behavioral deficits, striatal neuroinflammatory changes including altered microglial complexity and synaptic pruning, and markedly reduced Pde10a expression. Pde10a inhibition starting immediately after birth restores Foxp1± behavior, microglial morphology, and pruning ...
Henning Fröhlich, Jing Wang, Ferdinand Althammer, Tim Schubert, Nina Kluck, Valery Grinevich, Stefanie Schmitteckert, Christian P. Schaaf, Gudrun A. Rappold   +8 more
wiley   +1 more source

Structural basis of neuropeptide Y signaling through Y1 and Y2 receptors

MedComm
Neuropeptide Y (NPY), a 36‐amino‐acid peptide, functions as a neurotransmitter in both the central and peripheral nervous systems by activating the NPY receptor subfamily.
Siyuan Shen, Yue Deng, Chenglong Shen, Haidi Chen, Lin Cheng, Chao Wu, Chang Zhao, Zhiqian Yang, Hanlin Hou, Kexin Wang, Zhenhua Shao, Cheng Deng, Feng Ye, Wei Yan   +13 more
doaj   +1 more source

Afferent Neuronal Control of Type-I Gonadotropin Releasing Hormone Neurons in the Human. [PDF]

, 2013
Understanding the regulation of the human menstrual cycle represents an important ultimate challenge of reproductive neuroendocrine research. However, direct translation of information from laboratory animal experiments to the human is often complicated ...
Hrabovszky, Erik, Liposits, Zsolt
core   +1 more source

Quantitative analysis of neuropeptide Y receptor association with β-arrestin2 measured by bimolecular fluorescence complementation

British Journal of Pharmacology, 2010
Background and purpose:  β‐Arrestins are critical scaffold proteins that shape spatiotemporal signalling from seven transmembrane domain receptors (7TMRs).
L. Kilpatrick, S. Briddon, SJ Hill, N. Holliday   +3 more
semanticscholar   +1 more source

Dysfunctional Decidual CD4+T Cells Induce Recurrent Pregnancy Loss via Palmitoylation‐Dependent Tim‐3 Lysosomal Sorting and Degradation

Advanced Science, EarlyView.
Dysfunctional decidual CD4+T cells induce recurrent pregnancy loss via palmitoylation‐dependent Tim‐3 lysosomal sorting and degradation. The integrated bioinformatics, proteomic, functional and model studies elucidate that Tim‐3 is palmitoylated by ZDHHC3 at Cys9. Sortilin bound to and directed palmitoylated Tim‐3 toward lysosome degradation, resulting
Liyuan Cui, Xinhang Meng, Yujie Luo, Jinfeng Qian, Fengrun Sun, Mingke Qiu, Songcun Wang   +6 more
wiley   +1 more source