Results 71 to 80 of about 212,465 (393)

Structural basis of neuropeptide Y signaling through Y1 and Y2 receptors

MedComm
Neuropeptide Y (NPY), a 36‐amino‐acid peptide, functions as a neurotransmitter in both the central and peripheral nervous systems by activating the NPY receptor subfamily.
Siyuan Shen, Yue Deng, Chenglong Shen, Haidi Chen, Lin Cheng, Chao Wu, Chang Zhao, Zhiqian Yang, Hanlin Hou, Kexin Wang, Zhenhua Shao, Cheng Deng, Feng Ye, Wei Yan   +13 more
doaj   +1 more source

Quantitative analysis of neuropeptide Y receptor association with β-arrestin2 measured by bimolecular fluorescence complementation

British Journal of Pharmacology, 2010
Background and purpose:  β‐Arrestins are critical scaffold proteins that shape spatiotemporal signalling from seven transmembrane domain receptors (7TMRs).
L. Kilpatrick, S. Briddon, SJ Hill, N. Holliday   +3 more
semanticscholar   +1 more source

In Vivo Cytosolic Delivery of Biomolecules into Neurons for Super‐Resolution Imaging and Genome Modification

Advanced Science, EarlyView.
The N1 peptide specifically targets neurons, enabling cytosolic delivery of fluorescent dyes and proteins for super‐resolution imaging and functional genetic modification. Abstract Efficient delivery of biomolecules into neurons has significant impacts on therapeutic applications in the central nervous system (CNS) and fundamental neuroscience research.
Xiaoqian Ge, Joseph B. Wekselblatt, Scott Elmore, Bo Wang, Tongtong Wang, Renjinming Dai, Tingting Zhang, Harsh Dave, Mohammadaref Ghaderi, Athul Raj Anilkumar, Bill Wang, Shashank R. Sirsi, Jung‐Mo Ahn, Mikhail G. Shapiro, Yuki Oka, Carlos Lois, Zhenpeng Qin   +16 more
wiley   +1 more source

Cloning characterisation and expression of a G-protein-couple receptor from Lymnaea stagnalis and identification of a leucokinin-like peptide PSFHSWSamide as its endogenous ligand [PDF]

, 1997
No description ...
Burke, Julian F, Cox, Kingsley J A, Geraerts, Wijnand P M, Li, Ka Wan, Tensen, Cornelis P, Van der Schors, Roel C, van Heerikhuizen, Harm, Vreugdenhil, Erno   +7 more
core   +1 more source

Effects of Nifedipine on Renal and Cardiovascular Responses to Neuropeptide Y in Anesthetized Rats

Molecules, 2021
Neuropeptide Y (NPY) acts via multiple receptor subtypes termed Y1, Y2 and Y5. While Y1 receptor-mediated effects, e.g., in the vasculature, are often sensitive to inhibitors of L-type Ca2+ channels such as nifedipine, little is known about the role of ...
Angela Bischoff, Martina Stickan-Verfürth, Martin C. Michel   +2 more
doaj   +1 more source

Neuropeptide Y receptors in a protozoaStylonychia mytilus

Chinese Science Bulletin, 1998
Radio ligand binding assays(RLBA) were used to study neuropeptide Y (NPY) receptors in a protozoaStylonychia mytilus. The experimental results showed that 2–3 × 103/mLStylonychia cells incubated in Pringsheim solution which contained3H-NPY could specifically bind3H-NPY and concoraitantly present saturable characteristic.
Xiaoyun Zhang, Xiaoyang He, Yunhong Zhen
openaire   +2 more sources

MAGEA6 Engages a YY1‐Dependent Transcription to Dictate Perineural Invasion in Colorectal Cancer

Advanced Science, EarlyView.
This study investigates the role of MAGEA6 in perineural invasion (PNI) in colorectal cancer (CRC). MAGEA6 promotes CRC invasiveness by inhibiting YY1 ubiquitination, enhancing CXCL1 secretion, and recruiting Schwann cells. These findings highlight the potential of targeting the MAGEA6/YY1/CXCL1 axis for therapeutic strategies against PNI and tumor ...
Hao Wang, Kexin He, Ruixue Huo, Weihan Li, Shan Zhang, Lu‐Ju Jiang, Hao Wu, Minhao Yu, Shu‐Heng Jiang, Junli Xue   +9 more
wiley   +1 more source

Galanin receptor 2 modifies neuropeptide Y Y1 receptor internalization and β-Arrestin recruitment [PDF]

, 2015
We have recently described a Galanin receptor 2(GALR2) and Neuropeptide Y Y1 receptor(NPYY1R) interaction at behavioural, cellular and receptor levels through GALR2/NPYY1R heterodimers.
Borroto-Escuela, Dasiel, Díaz-Cabiale, Zaida, Flores-Burgess, Antonio, Fuxe, Kjell, Gago, Belén, Millón, Carmelo, Narváez, José Ángel, Narváez, Manuel, Santin-Nuñez, Luis Javier   +8 more
core  

NG peptides: A novel family of neurophysin-associated neuropeptides [PDF]

, 2010
NOTICE: this is the author’s version of a work that was accepted for publication in GENE. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be ...
Bromham, De Bree, De Bree, Elphick, Gwee, Inoue, Ivell, Iwakoshi, Kato, Kawada, Legros, Maurice R. Elphick, Putnam, Reinscheid, Roth, Stafflinger, Terhzaz, Ukena, Van Kesteren, Verleyen, Xu   +20 more
core   +1 more source

Combined gene overexpression of neuropeptide Y and its receptor Y5 in the hippocampus suppresses seizures

Neurobiology of Disease, 2012
We recently demonstrated that recombinant adeno-associated viral vector-induced hippocampal overexpression of neuropeptide Y receptor, Y2, exerts a seizure-suppressant effect in kindling and kainate-induced models of epilepsy in rats.
Casper R. Gøtzsche, Litsa Nikitidou, Andreas T. Sørensen, Mikkel V. Olesen, Gunnar Sørensen, Søren H.O. Christiansen, Mikael Ängehagen, David P.D. Woldbye, Merab Kokaia   +8 more
doaj