Results 71 to 80 of about 87,108 (308)

Effects of Nifedipine on Renal and Cardiovascular Responses to Neuropeptide Y in Anesthetized Rats

Molecules, 2021
Neuropeptide Y (NPY) acts via multiple receptor subtypes termed Y1, Y2 and Y5. While Y1 receptor-mediated effects, e.g., in the vasculature, are often sensitive to inhibitors of L-type Ca2+ channels such as nifedipine, little is known about the role of ...
Angela Bischoff, Martina Stickan-Verfürth, Martin C. Michel   +2 more
doaj   +1 more source

Human Atlas of Tooth Decay Progression: Identification of Cellular Mechanisms Driving the Switch from Dental Pulp Repair Toward Irreversible Pulpitis

Advanced Science, EarlyView.
Tooth decay progression transforms the dental pulp response from repair to fibrosis. At early stages, stromal cells reprogram to repair the extra cellular matrix (ECM), blood vessels, and nerves, remodel and grow, keeping repair possible. In advanced decay, hypoxia, and vessel regression, in complement with an immune switch, fuel nerve degeneration and
Hoang Thai Ha, Sofya Kosmynina, Amandine Verocq, Keremsah Ozen, Ines Tekia, Hugo Bussy, Marie Ramirez, Dima Sabbah, Chloe Goemans, Valerie Vandenbempt, Esteban N. Gurzov, Sumeet Pal Singh, Nicolas Baeyens   +12 more
wiley   +1 more source

Elevated Neuropeptide Y in Endothelial Dysfunction Promotes Macrophage Infiltration and Smooth Muscle Foam Cell Formation

Frontiers in Immunology, 2019
Endothelial dysfunction has been linked to vascular inflammation and foam cell formation but the underlying mechanisms still remain unclear. We sought to define the factors inducing inflammation and smooth muscle foam cell formation under endothelial ...
Bongkun Choi, Bongkun Choi, Min-Kyung Shin, Min-Kyung Shin, Eun-Young Kim, Eun-Young Kim, Ji-Eun Park, Ji-Eun Park, Halim Lee, Seong Who Kim, Seong Who Kim, Jae-Kwan Song, Eun-Ju Chang, Eun-Ju Chang, Eun-Ju Chang   +14 more
doaj   +1 more source

Galanin receptor 2 modifies neuropeptide Y Y1 receptor internalization and β-Arrestin recruitment [PDF]

, 2015
We have recently described a Galanin receptor 2(GALR2) and Neuropeptide Y Y1 receptor(NPYY1R) interaction at behavioural, cellular and receptor levels through GALR2/NPYY1R heterodimers.
Borroto-Escuela, Dasiel, Díaz-Cabiale, Zaida, Flores-Burgess, Antonio, Fuxe, Kjell, Gago, Belén, Millón, Carmelo, Narváez, José Ángel, Narváez, Manuel, Santin-Nuñez, Luis Javier   +8 more
core  

Reversal of age-related learning deficiency by the vertebrate PACAP and IGF-1 in a novel invertebrate model of aging: the pond snail (Lymnaea Stagnalis) [PDF]

, 2014
With the increase of life span, nonpathological age-related memory decline is affecting an increasing number of people. However, there is evidence that age-associated memory impairment only suspends, rather than irreversibly extinguishes, the intrinsic ...
Alexander, Audesirk, Chaudhury, D. Regl di, Delcourt, Du, G. Kemenes, Hattiangady, Hermann, Hernadi, I. Kemenes, J  zsa, Kemenes, Kemenes, Lee, Markowska, Otto, Otto, Patel, Patel, Pavlopoulos, Pirger, Pirger, Pirger, Roberto, S. Naskar, Sacchetti, Shioda, Silhol, Tamas, Telegdy, Vaudry, Watson, Watson, Yang, Yeoman, Z. Laszlo, Z. Pirger, Zhang   +38 more
core   +2 more sources

Precise Regulation of Membrane Proteins: From Physical Technology to Biomolecular Strategy

Advanced Science, EarlyView.
This review summarizes the emerging strategies for the precise regulation of membrane proteins using physical stimuli and biomolecule‐based tools. These methods provide new insights into cell regulation and offer promising directions for future disease treatment.
Xiu Zhao, Qingqing Zhou, Mengli Li, Wen Zou, Zhenzhong Zhang, Jinjin Shi, Junjie Liu   +6 more
wiley   +1 more source

The organisation of spinoparabrachial neurons in the mouse [PDF]

, 2015
The anterolateral tract (ALT), which originates from neurons in lamina I and the deep dorsal horn, represents a major ascending output through which nociceptive information is transmitted to brain areas involved in pain perception.
Cameron, Darren, Gomez-Lima, Maria, Gutierrez-Mecinas, Maria, Polgár, Erika, Todd, Andrew J., Watanabe, Masahiko   +5 more
core   +1 more source

High-affinity neuropeptide Y receptor antagonists. [PDF]

Proceedings of the National Academy of Sciences, 1995
Neuropeptide Y (NPY) is one of the most abundant peptide transmitters in the mammalian brain. In the periphery it is costored and coreleased with norepinephrine from sympathetic nerve terminals. However, the physiological functions of this peptide remain unclear because of the absence of specific high-affinity receptor antagonists.
A J, Daniels, J E, Matthews, R J, Slepetis, M, Jansen, O H, Viveros, A, Tadepalli, W, Harrington, D, Heyer, A, Landavazo, J J, Leban, A, Spaltenstein   +10 more
openaire   +2 more sources

An Automated Organotypic SCN Culture System Revealing Novel Insights into VIP Regulation of Circadian Rhythm

Advanced Science, EarlyView.
An Automated ex vivo culture system BaSIC, tailored for SCN slices and cell culture, which automates medium exchange and ensures a stable internal environment is developed. BaSIC enables real‐time observation of tissue/cell responses to diverse but programmed stimuli.
Kui Han, Meimei Liao, Jingpeng Zhang, Ruoyu Zhong, Long Mei, Dapeng Ju, Eric Erquan Zhang, Yanyi Huang   +7 more
wiley   +1 more source

Global parameter search reveals design principles of the mammalian circadian clock [PDF]

, 2008
Background: Virtually all living organisms have evolved a circadian (~24 hour) clock that controls physiological and behavioural processes with exquisite precision throughout the day/night cycle.
AC Liu, Achim Kramer, AT Winfree, BC Goodwin, D Gonze, D Somers, DB Forger, DB Forger, DK Welsh, ES Maywood, H Albus, H Kunz, Hanspeter Herzel, HD Piggins, James CW Locke, JC Dunlap, JC Leloup, JCW Locke, JCW Locke, JD Best, JE Quintero, JP Wisor, JS Griffith, K Vanselow, M Gallego, M Nagano, MC Antle, MH Hastings, MY Cheng, P Achermann, Pål O Westermark, RA Prosser, S Becker-Weimann, S Bernard, S Bornholdt, S Honma, S Yamazaki, SH Strogatz, SH Strogatz, SJ Aton, SJ Aton, SJ Kuhlman, TL To, VK Gribkoff, VM King, W Nakamura, Y Shigeyoshi   +46 more
core   +5 more sources